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The map label for this gene is hemA

Identifier: 49187358

GI number: 49187358

Start: 4274078

End: 4275412

Strand: Reverse

Name: hemA

Synonym: BAS4363

Alternate gene names: 49187358

Gene position: 4275412-4274078 (Counterclockwise)

Preceding gene: 49187361

Following gene: 49187357

Centisome position: 81.77

GC content: 37.23

Gene sequence:

>1335_bases
GTGCATATTCTTGTTGTTAGTGTAAATTATCGAACAGCCCCTGTAGAATTTCGTGAGAAACTCACATTTCAGGCAGCAGA
GCTAGAGCGAGCAATGACGACATTACAAAATCAAAAGAGCGTGTTAGAGAATGTCATTGTATCAACTTGTAATCGTACTG
AGATTTACGCTGTTGTCGATCAATTACACACGGGACGGTATTATATTAAGAAATTTTTAGCTGATTGGTTTCAGCTTGAA
ATAGAAGAAGTCGCACCATATTTAACTATTTTTGAACAAGATGGTGCAATAGATCATTTATTCCGCGTAACGTGCGGTTT
AGATTCTATGGTAGTTGGAGAGACGCAAATTTTAGGTCAAATAAAAGATAGCTTTTTAGAAGCACAACAAGTAAAAGCAA
CAGGAACAATTTTTAATGAATTGTTTAAGCAAGTCATTACATTAGCAAAACGCGCGCACTCAGAAACGACAATTGGTGAA
AGTGCGATGTCTGTTAGTTATGCTGCTGTTGAGTTAGGGAAGAAAATATTCGGCGAGTTAACAGATTGTCACGTGCTTAT
TCTCGGTGCTGGTAAAATGGGTGAACTTGCACTGCAGAACTTATATGGAAGCGGTGCTCGTAAAGTAACAGTTATGAATA
GGACGCTTTCAAAAGCAGAAATAATGGCTGAGAAATATATGGGACATGCAAAACCTTTAAGTGAATTACAATGTGCATTA
TTAGAAGCTGATATTTTAATTAGTTCAACGGGTGCATCGGATTATGTTATTACGAAAGAGATGATGACAAAGGTAGAGAA
AATGCGCTCTGGCCGTCCATTATTTATGGTTGATATTGCAGTGCCGCGTGATATTGATCCAGCGATTGATGAGCTAGAAG
GTTCTTTCTTATATGACATTGATGATTTGCAAGGAGTAGTGGAAGCAAACCGTGCTGAACGTTTGAAAGAAGCAGAGAAA
ATTCAATTTATGATTGAAGAGGAAATTGTTTTATTTAAAACGTGGTTAAGTACACTTGGTGTCGTTCCGTTAATATCAGC
TCTTCGTGATAAGGCACTTGCTATCCAAAGTGAAACGATGGAAAGTCTGGAACGAAAAATACCGAATCTTAGTGATCGTG
AGAGAAAAGTAATTAGTAAGCATACGAAAAGTATTATTAATCAATTATTAAAAGACCCAATTTTAGTAGCGAAAGAAATA
GCTGCTGAAGAGGGAGCAGACGAAAAATTAGCGTTATTTGCAAAGATTTTCGATTTAGAAATGGAAGACGTAGAGAGTCG
TGCGGAAGAAGTAGAACATAAAAGAGTGTGGACACCATCCGTTCCATCTTTATAA

Upstream 100 bases:

>100_bases
AAAAATAATCAGTTGTTCACACGATTGTCAGATTCATAAGAGGAAAGTTGTATTATGATAGTAGATAAAGTGATAAAACG
GGTGAAGGGGGACATGCTGC

Downstream 100 bases:

>100_bases
TTTGGAAGGATGATCGGATGAGTTTTTTAAATAACAGTATTATTTATCATATTGCAATTATTTTATATGCTTGTAGCATT
AGTTTATATTTTATAGATTA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCAL
LEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEK
IQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEI
AAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRVWTPSVPSL

Sequences:

>Translated_444_residues
MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCAL
LEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEK
IQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEI
AAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRVWTPSVPSL
>Mature_444_residues
MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCAL
LEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEK
IQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEI
AAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRVWTPSVPSL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=420, Percent_Identity=33.0952380952381, Blast_Score=236, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_BACAA (C3P9F1)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868750.1
- ProteinModelPortal:   C3P9F1
- SMR:   C3P9F1
- EnsemblBacteria:   EBBACT00000128206
- GeneID:   7850947
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4716
- GeneTree:   EBGT00050000001402
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 49825; Mature: 49825

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVD
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
IKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCAL
CCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDI
HHHHHEEECCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCEEEEH
DDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEIAAEEGADEKLALFAKIFDLE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHCC
MEDVESRAEEVEHKRVWTPSVPSL
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVD
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
IKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCAL
CCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDI
HHHHHEEECCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCEEEEH
DDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEIAAEEGADEKLALFAKIFDLE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHCC
MEDVESRAEEVEHKRVWTPSVPSL
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA