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The map label for this gene is hemN [H]

Identifier: 49187212

GI number: 49187212

Start: 4131721

End: 4132860

Strand: Reverse

Name: hemN [H]

Synonym: BAS4216

Alternate gene names: 49187212

Gene position: 4132860-4131721 (Counterclockwise)

Preceding gene: 49187213

Following gene: 49187211

Centisome position: 79.04

GC content: 36.4

Gene sequence:

>1140_bases
TTGGTGCAAGCTGCATATATTCATATTCCGTTTTGTCAGCATATTTGTCACTATTGTGATTTTAATAAAGTGTTTATTGA
ACGCCAGCCGGTGGATCAATATTTAGAGTATTTAGAGAAAGAAATAATAAATACAGTTCAAAAGGTACCGTTTGATAGTA
TGAAAACGATTTTTGTTGGCGGGGGAACTCCGACAGCATTAAATATGGAGCAGACAAAGAAATTATTAGATATAATAAAT
CGTCGTTTACGTCCGTTTGCCCCGAATTGTGAATTAACATTTGAAGCGAATCCAGGTGATTTGCCGAAAGAGAAATTAAA
TGTATTGCTAGAGGGTGGAGTGAACCGAATTAGTTTTGGTGTGCAAACATTTCGAGATGAACTGCTTGAGAAAATTGGGC
GTAAGCATACGAGAGAAGATGCGTTTGTAGCAATTAGAGAAGCGCAGGAAGTGGGCTTCAAAAATATAAATGTAGATATT
ATTTACGCTCTGCCAGGGCAGACGATAGAAGATGTGAAAGAAACGTTAGATATTGCTTTTACGCTTGGTGTACAACATTT
CTCGGCATATTCATTAATTGTGGAACCGAAAACTGTGTTTTATAACTTAATGAATAAAGGGAAATTAAGACTTCCAGGGG
AAGACCATGAAGCGAAAATGTATGAAATGGTAATGGATGAAATGGAGAGACACGGCTATACCCAGTATGAAATTAGTAAT
TTTTCAAAAGGTGATAATGAAAGTAGGCATAATCTCACATACTGGAATAATGAAGAGTATTATGGGTTTGGAGCTGGAGC
GCATAGTTATGTAAATGGAGAACGTATCCAAAATGTAGGACCGCTCAAACAATATTTCAATAAAATCGATGAAACCGGGT
TTCCGTATTTAGATGTTCATGTGGTGACGGAGAAAGAAAAAATGGAAGAAGAGTTGTTCTTAGGTCTTCGTAAAACAAAA
GGTGTGTCAAAAATGGCGTTCCGCAATAAATTTAATGTGGAAATGAATCAAGTTTTCGCGAAGCAGTTACAAAACAACCA
AGAACAAGGATTGCTTGAAGAGAGCGATGGATATGTTCGTTTAACGCGAAAAGGGAAATTATTAGGGAATGAAGTATTCC
AATCATTTTTGATTGACTAA

Upstream 100 bases:

>100_bases
TGGGGAAAAATGCGAATGGAACAAATTCGTAATACGTTAGAGAAGTAAAAGAAGCCTCCCGAGCGCGGAGGTTTTCTTTT
TAGAAAGGTAGGAGTTATTT

Downstream 100 bases:

>100_bases
TTACATGTTCCATGAACGTGAAAAAGTTTCATTATTTCGTGACGTTTCCGTTGACAATTGAATGTCAATTTTGGTAAGTT
ATTAATAGATTTAGCACTCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MVQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVPFDSMKTIFVGGGTPTALNMEQTKKLLDIIN
RRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDI
IYALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISN
FSKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTK
GVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID

Sequences:

>Translated_379_residues
MVQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVPFDSMKTIFVGGGTPTALNMEQTKKLLDIIN
RRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDI
IYALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISN
FSKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTK
GVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID
>Mature_379_residues
MVQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVPFDSMKTIFVGGGTPTALNMEQTKKLLDIIN
RRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDI
IYALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISN
FSKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTK
GVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=30.9433962264151, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1789325, Length=379, Percent_Identity=33.245382585752, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082341, Length=387, Percent_Identity=26.8733850129199, Blast_Score=151, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43865; Mature: 43865

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVPFDSMKTIFVG
CCEEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GGTPTALNMEQTKKLLDIINRRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFG
CCCCCEECHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
VQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDIIYALPGQTIEDVKETLDIAF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
TLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISN
HHHHHHHCEEEEEECHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECC
FSKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVH
CCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCEEEEE
VVTEKEKMEEELFLGLRKTKGVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVR
EECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCEECCCCEEE
LTRKGKLLGNEVFQSFLID
EEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVPFDSMKTIFVG
CCEEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GGTPTALNMEQTKKLLDIINRRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFG
CCCCCEECHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
VQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDIIYALPGQTIEDVKETLDIAF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
TLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISN
HHHHHHHCEEEEEECHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECC
FSKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVH
CCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCEEEEE
VVTEKEKMEEELFLGLRKTKGVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVR
EECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCEECCCCEEE
LTRKGKLLGNEVFQSFLID
EEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]