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The map label for this gene is metC [H]

Identifier: 49187156

GI number: 49187156

Start: 4076096

End: 4077259

Strand: Direct

Name: metC [H]

Synonym: BAS4159

Alternate gene names: 49187156

Gene position: 4076096-4077259 (Clockwise)

Preceding gene: 49187155

Following gene: 49187157

Centisome position: 77.96

GC content: 38.75

Gene sequence:

>1164_bases
ATGAGTTATTCTATAGATACACTCTTACTACACAACCAATATAAACATGATCCACAAACAGGAGCTGTTAACGTTCCCAT
CTATAACACATCAACATTCCACCAGTTCGATGTAGATACGTTCGGGAAATATGACTATAGCAGGTCAGGAAATCCAACTC
GTGAAGCTCTTGAAGACATCATTGCTTTATTAGAAGGCGGAACGAAAGGATTTGCCTTCGCATCAGGAATTGCAGCGATT
TCTACTGCATTCCTCCTTCTTTCACAAGGTGATCACGTACTCATTTCAGAAGACGTATACGGAGGGACTTATCGAATAAT
AACTGAAGTTCTCTCCCGTTATGGTGTTTCACATACATTTGTTGATATGACCAATCTAGAAGAAATCAAGCAAAATATAA
AACAAAATACAAAGCTCTTTTATGTAGAAACACCTTCTAACCCGCTTTTAAAAGTAACAGATATTCGTGCTGTTTCTACA
CTTGCAAAATCTATTGGCGCTCTTACTTTTGTTGATAATACATTTTTGACACCACTATTCCAGAAACCACTTGATCTCGG
CGCAGATGTCGTTCTTCATAGCGCTACAAAGTTCATTGCTGGTCACAGTGATGTTACTGCTGGATTAGCGGTCGTAAAAG
ATGCCGAACTTGCTCAAAAACTTGGATTTTTACAAAATGCATTCGGCGCCATTTTAGGACCTCAAGATTGCTCTCTCGTA
CTTCGCGGTCTAAAAACATTACATGTACGTCTTGAGCATTCAGCTGCGAATGCCAATAAAATTGCACAGTATTTACAAGA
GCACAGTAAAATTCAAAATGTCTATTATCCTGGCTTACAAACACATCTTGGATTTGATATTCAACAATCTCAAGCAACAT
CGGCCGGAGCTGTCCTATCCTTCACTTTACAATCAGAAGATGCACTCCGCCAATTTTTATCAAAAGTAAAATTACCTGTC
TTTGCAGTTAGTTTAGGAGCTGTCGAATCGATTCTTTCCTATCCGGCTAAAATGTCACATGCAGCACTGTCACAAGAAGC
TCGTGATGAAAGAGGTATTTCCAATTCATTACTTCGTTTATCCGTCGGCCTTGAAAATGTTGATGATTTAATATCCGACT
TTGAAAATGCCCTTTCTTATGTAGAAGAACCTGTAAATGCATAG

Upstream 100 bases:

>100_bases
GTAATCGTCTTCTTCGATTTTCTGTTGGCATTGAAAATAGTAACGATTTAATTCAAGACTTACAGCAAGCCATTAAACTT
GTAAAAGAAGGTGTAAGAAT

Downstream 100 bases:

>100_bases
AATGAACAGAAGATATGAAATTAAGTTTTCATATCTTCTGTTTACATAGTTCACAAAAAATAAATCCATTACCTTCTATT
TCAAGGTAATTGATTTATTG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSYSIDTLLLHNQYKHDPQTGAVNVPIYNTSTFHQFDVDTFGKYDYSRSGNPTREALEDIIALLEGGTKGFAFASGIAAI
STAFLLLSQGDHVLISEDVYGGTYRIITEVLSRYGVSHTFVDMTNLEEIKQNIKQNTKLFYVETPSNPLLKVTDIRAVST
LAKSIGALTFVDNTFLTPLFQKPLDLGADVVLHSATKFIAGHSDVTAGLAVVKDAELAQKLGFLQNAFGAILGPQDCSLV
LRGLKTLHVRLEHSAANANKIAQYLQEHSKIQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEDALRQFLSKVKLPV
FAVSLGAVESILSYPAKMSHAALSQEARDERGISNSLLRLSVGLENVDDLISDFENALSYVEEPVNA

Sequences:

>Translated_387_residues
MSYSIDTLLLHNQYKHDPQTGAVNVPIYNTSTFHQFDVDTFGKYDYSRSGNPTREALEDIIALLEGGTKGFAFASGIAAI
STAFLLLSQGDHVLISEDVYGGTYRIITEVLSRYGVSHTFVDMTNLEEIKQNIKQNTKLFYVETPSNPLLKVTDIRAVST
LAKSIGALTFVDNTFLTPLFQKPLDLGADVVLHSATKFIAGHSDVTAGLAVVKDAELAQKLGFLQNAFGAILGPQDCSLV
LRGLKTLHVRLEHSAANANKIAQYLQEHSKIQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEDALRQFLSKVKLPV
FAVSLGAVESILSYPAKMSHAALSQEARDERGISNSLLRLSVGLENVDDLISDFENALSYVEEPVNA
>Mature_386_residues
SYSIDTLLLHNQYKHDPQTGAVNVPIYNTSTFHQFDVDTFGKYDYSRSGNPTREALEDIIALLEGGTKGFAFASGIAAIS
TAFLLLSQGDHVLISEDVYGGTYRIITEVLSRYGVSHTFVDMTNLEEIKQNIKQNTKLFYVETPSNPLLKVTDIRAVSTL
AKSIGALTFVDNTFLTPLFQKPLDLGADVVLHSATKFIAGHSDVTAGLAVVKDAELAQKLGFLQNAFGAILGPQDCSLVL
RGLKTLHVRLEHSAANANKIAQYLQEHSKIQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEDALRQFLSKVKLPVF
AVSLGAVESILSYPAKMSHAALSQEARDERGISNSLLRLSVGLENVDDLISDFENALSYVEEPVNA

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=376, Percent_Identity=42.5531914893617, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI299473759, Length=355, Percent_Identity=38.0281690140845, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=37.6, Blast_Score=221, Evalue=7e-58,
Organism=Escherichia coli, GI1790375, Length=382, Percent_Identity=40.8376963350785, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=29.6954314720812, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=356, Percent_Identity=43.5393258426966, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17538055, Length=344, Percent_Identity=43.8953488372093, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=38.4196185286104, Blast_Score=253, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI193202265, Length=89, Percent_Identity=41.5730337078652, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=44.6866485013624, Blast_Score=299, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=35.5, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321170, Length=318, Percent_Identity=30.8176100628931, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323333, Length=446, Percent_Identity=29.5964125560538, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=28.391959798995, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323557, Length=343, Percent_Identity=24.7813411078717, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322970, Length=350, Percent_Identity=24.8571428571429, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322590, Length=357, Percent_Identity=24.3697478991597, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922554, Length=363, Percent_Identity=44.0771349862259, Blast_Score=299, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42189; Mature: 42058

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00368 RIBORED_SMALL ; PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSIDTLLLHNQYKHDPQTGAVNVPIYNTSTFHQFDVDTFGKYDYSRSGNPTREALEDI
CCCCCHHHEECCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHH
IALLEGGTKGFAFASGIAAISTAFLLLSQGDHVLISEDVYGGTYRIITEVLSRYGVSHTF
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEE
VDMTNLEEIKQNIKQNTKLFYVETPSNPLLKVTDIRAVSTLAKSIGALTFVDNTFLTPLF
EEHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHCCEEEECCHHHHHHH
QKPLDLGADVVLHSATKFIAGHSDVTAGLAVVKDAELAQKLGFLQNAFGAILGPQDCSLV
HCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LRGLKTLHVRLEHSAANANKIAQYLQEHSKIQNVYYPGLQTHLGFDIQQSQATSAGAVLS
HHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHCCCCCCEEEE
FTLQSEDALRQFLSKVKLPVFAVSLGAVESILSYPAKMSHAALSQEARDERGISNSLLRL
EEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHEEE
SVGLENVDDLISDFENALSYVEEPVNA
ECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYSIDTLLLHNQYKHDPQTGAVNVPIYNTSTFHQFDVDTFGKYDYSRSGNPTREALEDI
CCCCHHHEECCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHH
IALLEGGTKGFAFASGIAAISTAFLLLSQGDHVLISEDVYGGTYRIITEVLSRYGVSHTF
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEE
VDMTNLEEIKQNIKQNTKLFYVETPSNPLLKVTDIRAVSTLAKSIGALTFVDNTFLTPLF
EEHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHCCEEEECCHHHHHHH
QKPLDLGADVVLHSATKFIAGHSDVTAGLAVVKDAELAQKLGFLQNAFGAILGPQDCSLV
HCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LRGLKTLHVRLEHSAANANKIAQYLQEHSKIQNVYYPGLQTHLGFDIQQSQATSAGAVLS
HHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHCCCCCCEEEE
FTLQSEDALRQFLSKVKLPVFAVSLGAVESILSYPAKMSHAALSQEARDERGISNSLLRL
EEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHEEE
SVGLENVDDLISDFENALSYVEEPVNA
ECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]