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The map label for this gene is ribBA

Identifier: 49187018

GI number: 49187018

Start: 3956591

End: 3957784

Strand: Direct

Name: ribBA

Synonym: BAS4020

Alternate gene names: 49187018

Gene position: 3956591-3957784 (Clockwise)

Preceding gene: 49187017

Following gene: 49187019

Centisome position: 75.67

GC content: 40.12

Gene sequence:

>1194_bases
ATGTTTCATCGTATTGAAGAAGCTCTAGAAGATTTAAAACAAGGAAAAGTCGTTATCGTATGTGATGATGAAAACCGTGA
AAACGAAGGCGATTTTATCGCTTTAGCAGAGTATATTACGCCCGAAACAATTAACTTTATGATTACACATGGACGCGGTC
TCGTTTGTGTACCGATTACGGAAGGATACGCAGAACGTCTACAATTAGAACCAATGGTATCTCATAATACAGATTCGCAT
CATACTGCATTTACAGTGAGCATTGACCATGTTTCTACAACAACAGGCATTAGCGCTCACGAACGTGCAACTACAATACA
ACAATTGTTAAATCCTGCATCAAAAGGTGCTGATTTCAATCGACCTGGACATATCTTTCCATTAATCGCGAAAGAAGGCG
GTGTCCTGCGTCGTGCTGGTCATACAGAAGCTGCTGTCGATTTAGCACAGCTTTGCGGAGCAGAACCAGCTGGAGTCATT
TGCGAGATTATCAATGAGGACGGTACGATGGCACGCGTCCCTGATTTACTACAGTGTGCAAAACAATTTGATATAAAAAT
GATTACAATAGAAGATTTAATTGCTTATCGCCGCCATCATGAAACACTTGTGACGAGAGAAGTGGAAATTACATTACCTA
CAGATTTCGGTACTTTTCAAGCAATTGGCTATTCTAACTCATTAGATACGAAAGAACATATTGCACTCGTAAAAGGTGAT
ATTTCAACAGGTGAGCCTGTACTTGTACGCGTTCATTCAGAGTGCTTAACAGGAGATGTATTTGGCTCGTGCCGCTGTGA
TTGCGGACCACAACTCCATGCTGCACTTGCTCAAATTGAACGTGAAGGAAAAGGCGTTCTTCTTTATATGAGACAAGAAG
GACGAGGCATTGGCCTTCTTAATAAGCTTCGCGCTTATAAGTTACAAGAAGAAGGCTTCGATACTGTAGAAGCAAACGAA
AAACTTGGGTTTCCCGCTGACCTTCGTGATTACGGTATCGGCGCTCAAATATTAAAAGATTTAGGTTTACAACATTTACG
ATTATTAACGAATAATCCAAGAAAAATCGCTGGCTTACAAGGTTACGATTTAACCGTTACGGAGCGCGTACCGTTGCAAA
TGCCAGCAAAAGAAGAGAATAAAACGTATTTACAAACGAAAGTAAACAAATTAGGACATTTATTAAACTTATAA

Upstream 100 bases:

>100_bases
TAAATATATCGAACGCTTTATTACTAAGCCTGTAAAACGAACAGGTTCAATGACCGAAAACTTTTTACAAGAAAACGGAT
TTCTATAAGGGGGAAGCATT

Downstream 100 bases:

>100_bases
TTAAAGGAGAGATTTATTATGGTATTCGAAGGTCATTTAGTTGGTACAGGATTAAAAGTTGGGGTTGTTGTTGGACGTTT
TAATGAATTTATTACAAGTA

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGTMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL

Sequences:

>Translated_397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGTMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
>Mature_397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGTMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=55.440414507772, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=50.2487562189055, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=45.1923076923077, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.6140350877193, Blast_Score=133, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBBA_BACAA (C3P7P7)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868412.1
- ProteinModelPortal:   C3P7P7
- EnsemblBacteria:   EBBACT00000130003
- GeneID:   7848253
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4355
- GeneTree:   EBGT00050000001077
- ProtClustDB:   PRK09311
- HAMAP:   MF_01283
- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF001259
- TIGRFAMs:   TIGR00505
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12; =3.5.4.25

Molecular weight: Translated: 43908; Mature: 43908

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: ACT_SITE 327-327 ACT_SITE 329-329 BINDING 31-31 BINDING 162-162 BINDING 271-271 BINDING 315-315 BINDING 350-350 BINDING 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPIT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEECC
EGYAERLQLEPMVSHNTDSHHTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFN
CCHHHHEEECCHHCCCCCCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHCHHHCCCCCC
RPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVICEIINEDGTMARVPDLLQCA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCHHHHHHH
KQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
HHCCEEEEEHHHHHHHHHHHHHEEEEEEEEEECCCCCCEEEECCCCCCCCCHHEEEEECC
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLL
CCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
NKLRAYKLQEEGFDTVEANEKLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCHHHHHHHCCCCCEEECCC
GYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPIT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEECC
EGYAERLQLEPMVSHNTDSHHTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFN
CCHHHHEEECCHHCCCCCCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHCHHHCCCCCC
RPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVICEIINEDGTMARVPDLLQCA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCHHHHHHH
KQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
HHCCEEEEEHHHHHHHHHHHHHEEEEEEEEEECCCCCCEEEECCCCCCCCCHHEEEEECC
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLL
CCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
NKLRAYKLQEEGFDTVEANEKLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCHHHHHHHCCCCCEEECCC
GYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA