| Definition | Bacillus anthracis str. Sterne chromosome, complete genome. |
|---|---|
| Accession | NC_005945 |
| Length | 5,228,663 |
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The map label for this gene is ytbE [H]
Identifier: 49187004
GI number: 49187004
Start: 3944344
End: 3945171
Strand: Reverse
Name: ytbE [H]
Synonym: BAS4006
Alternate gene names: 49187004
Gene position: 3945171-3944344 (Counterclockwise)
Preceding gene: 49187005
Following gene: 49187002
Centisome position: 75.45
GC content: 37.08
Gene sequence:
>828_bases GTGCACATTCCAACAACTACACTTCATAATGGCGTAAAAATGCCGATGATTGGTTTAGGCGTTTATAAAGCGAAAGAAGG CGACGAAGTAAAACAAGCAGTAAAAACAGCGCTAGAAGTTGGATACCGTTCGATTGATACAGCAACTGTATATGAAAATG AAAGCGGTGTCGGAGAAGCGGTTCGTGAATCAGGAATTCCGAGAGAAGACATCTTTATTACAACAAAAGTTTGGAACGAC GATCAAGGATACGAGGAAACACTTGAGGCGTTTGAGAAAAGCTTAAAAAAATTACAAATGGACTATGTAGATTTATATTT AATACATTGGCCAATAAGAGGGAAGTATGTTGATACGTACCGAGCATTAGAAAAACTGTATGAAGAAGGTAAAGTGCGCG CGATTGGTGTTTCGAATTTCCATAAACATCATTTAGAACTGCTATTACCAAATTGCAAAATAAAGCCGATGGTAAACCAA GTGGAACTTCATCCCATGTTAACACAATTTGAATTGCGTAATTTTTGTCAAGGTGAGCAAATTCAAATGGAAGCATGGAG TCCATTAATGAGAGGTGGAGAAGTATTTCAGCACCCGATTATTCAGGCCATTGCTACTAAATATGAAAAAACACCTGCGC AAGTTATATTAAGGTGGGATATTCAAAGCGGGATTGTGACGATTCCTAAGTCTGTTACACCATCTCGCATTCAGGAGAAT TTTTCTATCTTTGACTTTTCACTAACAGAAGAAGAGATGACTGAAATTAATACGTTAAATCGTAATTTACATGTAGGAAC GAATCCTGATAAATATGATACGTTATAA
Upstream 100 bases:
>100_bases TTTATTATGTAAACTGTACATATGTTTTGACTTTTTGGTTGAATCTTGTTCAAATAAAGTGGTGGCTTATAAAAAATGTA ATGATGAAAGGGAGACGACT
Downstream 100 bases:
>100_bases AAAGACGCTACCAGTATGGTAGCGTCTTTTTAACGATGTAAAGCGTACGTATCACATTTAGCGATTTGCTGAAGCTGTAT ATATTCTTCTGTTGTTAACT
Product: aldo/keto reductase family oxidoreductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 275; Mature: 275
Protein sequence:
>275_residues MHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEAVRESGIPREDIFITTKVWND DQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRALEKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQ VELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQAIATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQEN FSIFDFSLTEEEMTEINTLNRNLHVGTNPDKYDTL
Sequences:
>Translated_275_residues MHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEAVRESGIPREDIFITTKVWND DQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRALEKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQ VELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQAIATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQEN FSIFDFSLTEEEMTEINTLNRNLHVGTNPDKYDTL >Mature_275_residues MHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEAVRESGIPREDIFITTKVWND DQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRALEKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQ VELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQAIATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQEN FSIFDFSLTEEEMTEINTLNRNLHVGTNPDKYDTL
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=40.8783783783784, Blast_Score=238, Evalue=3e-63, Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=40.8783783783784, Blast_Score=238, Evalue=3e-63, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=43.8356164383562, Blast_Score=226, Evalue=2e-59, Organism=Homo sapiens, GI310109922, Length=281, Percent_Identity=40.2135231316726, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=38.1578947368421, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=40.3389830508475, Blast_Score=209, Evalue=3e-54, Organism=Homo sapiens, GI5453543, Length=301, Percent_Identity=38.2059800664452, Blast_Score=206, Evalue=2e-53, Organism=Homo sapiens, GI45446745, Length=301, Percent_Identity=38.5382059800665, Blast_Score=205, Evalue=4e-53, Organism=Homo sapiens, GI4503285, Length=301, Percent_Identity=38.5382059800665, Blast_Score=205, Evalue=4e-53, Organism=Homo sapiens, GI310109920, Length=301, Percent_Identity=38.2059800664452, Blast_Score=205, Evalue=4e-53, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=43.0034129692833, Blast_Score=203, Evalue=1e-52, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=41.6370106761566, Blast_Score=203, Evalue=1e-52, Organism=Homo sapiens, GI24497583, Length=298, Percent_Identity=37.5838926174497, Blast_Score=198, Evalue=3e-51, Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=37.542662116041, Blast_Score=191, Evalue=8e-49, Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=37.8181818181818, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=38.8278388278388, Blast_Score=172, Evalue=4e-43, Organism=Homo sapiens, GI310109924, Length=157, Percent_Identity=38.8535031847134, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=46.4912280701754, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=45.6140350877193, Blast_Score=100, Evalue=2e-21, Organism=Escherichia coli, GI87082198, Length=276, Percent_Identity=48.1884057971014, Blast_Score=277, Evalue=4e-76, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=35.6862745098039, Blast_Score=163, Evalue=1e-41, Organism=Escherichia coli, GI1788081, Length=262, Percent_Identity=31.6793893129771, Blast_Score=132, Evalue=2e-32, Organism=Escherichia coli, GI1788070, Length=307, Percent_Identity=26.0586319218241, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI87081735, Length=271, Percent_Identity=25.830258302583, Blast_Score=70, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17537077, Length=297, Percent_Identity=40.0673400673401, Blast_Score=209, Evalue=1e-54, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=41.4179104477612, Blast_Score=206, Evalue=7e-54, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=38.7205387205387, Blast_Score=206, Evalue=1e-53, Organism=Caenorhabditis elegans, GI17537075, Length=294, Percent_Identity=40.1360544217687, Blast_Score=202, Evalue=2e-52, Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=36.4963503649635, Blast_Score=185, Evalue=2e-47, Organism=Caenorhabditis elegans, GI17550248, Length=282, Percent_Identity=38.6524822695035, Blast_Score=183, Evalue=9e-47, Organism=Caenorhabditis elegans, GI17538386, Length=271, Percent_Identity=39.1143911439114, Blast_Score=182, Evalue=2e-46, Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=38.2456140350877, Blast_Score=182, Evalue=2e-46, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=36.231884057971, Blast_Score=170, Evalue=8e-43, Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=37.956204379562, Blast_Score=159, Evalue=1e-39, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=31.9391634980989, Blast_Score=158, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=31.25, Blast_Score=156, Evalue=1e-38, Organism=Saccharomyces cerevisiae, GI6324694, Length=286, Percent_Identity=40.5594405594406, Blast_Score=213, Evalue=2e-56, Organism=Saccharomyces cerevisiae, GI6319625, Length=289, Percent_Identity=41.1764705882353, Blast_Score=199, Evalue=3e-52, Organism=Saccharomyces cerevisiae, GI6320576, Length=288, Percent_Identity=38.1944444444444, Blast_Score=197, Evalue=1e-51, Organism=Saccharomyces cerevisiae, GI6321896, Length=307, Percent_Identity=35.8306188925081, Blast_Score=181, Evalue=8e-47, Organism=Saccharomyces cerevisiae, GI6322556, Length=257, Percent_Identity=35.408560311284, Blast_Score=174, Evalue=2e-44, Organism=Saccharomyces cerevisiae, GI6320079, Length=279, Percent_Identity=34.7670250896057, Blast_Score=143, Evalue=2e-35, Organism=Drosophila melanogaster, GI24663317, Length=286, Percent_Identity=41.958041958042, Blast_Score=221, Evalue=3e-58, Organism=Drosophila melanogaster, GI24657054, Length=282, Percent_Identity=43.2624113475177, Blast_Score=216, Evalue=1e-56, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=38.3333333333333, Blast_Score=211, Evalue=5e-55, Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=39.9328859060403, Blast_Score=210, Evalue=1e-54, Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=42.0689655172414, Blast_Score=208, Evalue=4e-54, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=35.9375, Blast_Score=203, Evalue=1e-52, Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=39.5833333333333, Blast_Score=198, Evalue=3e-51, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=39.568345323741, Blast_Score=197, Evalue=6e-51, Organism=Drosophila melanogaster, GI24662781, Length=282, Percent_Identity=41.1347517730496, Blast_Score=188, Evalue=3e-48, Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=40.8602150537634, Blast_Score=183, Evalue=1e-46, Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=38.4920634920635, Blast_Score=168, Evalue=3e-42,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 31587; Mature: 31587
Theoretical pI: Translated: 5.61; Mature: 5.61
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEA CCCCCCCCCCCCCCCEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH VRESGIPREDIFITTKVWNDDQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTY HHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHH RALEKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQ HHHHHHHHCCCEEEEECCCHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE IQMEAWSPLMRGGEVFQHPIIQAIATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQEN EEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHCC FSIFDFSLTEEEMTEINTLNRNLHVGTNPDKYDTL CCEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCC >Mature Secondary Structure MHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEA CCCCCCCCCCCCCCCEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH VRESGIPREDIFITTKVWNDDQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTY HHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHH RALEKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQ HHHHHHHHCCCEEEEECCCHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE IQMEAWSPLMRGGEVFQHPIIQAIATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQEN EEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHCC FSIFDFSLTEEEMTEINTLNRNLHVGTNPDKYDTL CCEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]