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The map label for this gene is gltT [H]

Identifier: 49184680

GI number: 49184680

Start: 1681448

End: 1682719

Strand: Direct

Name: gltT [H]

Synonym: BAS1666

Alternate gene names: 49184680

Gene position: 1681448-1682719 (Clockwise)

Preceding gene: 49184678

Following gene: 49184681

Centisome position: 32.16

GC content: 36.95

Gene sequence:

>1272_bases
ATGAAAAAATTTGGATTAGCGACACAAATTTTTGTCGCACTTGTTTTAGGGATTGTAGTAGGGGCAATCTTCTATGGTAA
TAAAACGGCGATTTCTTATATCACACCAATTGGGGATATATTTATTCACTTAATTAAAATGATTGTAGTACCGATTGTTA
TTTCAGCATTAATTGTTGCGGTAGCTGGTGTAGGCGATATGAAGAAGCTTGGGAAACTAGGCGGAAAGACAATTCTTTAT
TTTGAAATCATTACGACGATCGCTATTTTAATGGGATTACTTGCGGCGAATATATTCCAGCCAGGTACTGGCGTTGATAT
GAATAACTTACAGCAAAGTGACATTTCTTCTTATAAACAAACAGCAGATGCTACAGAGAAGCAAGGATTCGCTGAGACGA
TTGTTCATATTGTACCGAAAAACGTATTTGAATCGATTGCACAAGGTGACTTATTACCGATTATTTTCTTCTCAGTATTA
TTCGGTTTAGGAGTTGCAGCAATTGGGGAAAAAGGAAAGCCTGTCTTTAACTTCTTTGAAGGTGTACTCGAAGCGATGTT
TTGGGTTACAAATCAAGTTATGAAATTTGCACCATTTGGTGTATTCGCATTAATTGCGGTTACGGTTGCAAAATTTGGTG
TAGCAACACTACTTCCTTTAGGAAAACTAGTGCTAGCTGTATACGTAACTGTTATACTATTCGTTGTGATTGTATTAGGT
ATTAATGCACGAATGGTTGGCGTAAATATTTTTACATTAATGAAAATTTTAAAAGAAGAACTAATTCTTTCATTTACGAC
AGCAAGTTCAGAAGCTGTTTTACCTAATATAATGAGAAAAATGGAAGAGTTCGGTTGTCCAAAGGCAGTTGCCTCTTTCG
TAATTCCGACAGGTTATACATTTAACTTGACTGGATCAGCTATTTATCAAGCGTTAGCGGCATTATTTGTTACACAAATG
TACGGTGTGCACATGTCACTGACAGAGCAAATAACGTTATTATTCGTTCTCATGTTAACATCCAAAGGTATGGCGGGAGT
TCCAGGTGCATCGTTCGTTGTTGTATTAGCAACGTTAGGTTCAATGGGGTTACCACTAGAAGGTATCGCGTTAATTGCGG
GAATTGACCGCATTTTAGATATGATTCGCTCATCTGTCAATGTATTAGGAAATGCATTAGCGGCCATTGTTATGTCGAAG
TGGGAAGGCGAATTCGATAATGAGAAAGCAAAACAATATGTAGAAACAGTCAAAGAAACAAAAGCAGCATAA

Upstream 100 bases:

>100_bases
TGTAGGTTTTTGTATGATTTTGTAGGTTCGCCTATATGATGTGTGAGTAAGCTTTTATAAATACGAAATGAAAGCGTTCT
CATAAAGGAGATGAACATAA

Downstream 100 bases:

>100_bases
GAAATCGTTAAGGAGTGAATAATCATGGCAACATTAACTGAAGTTAAAAATGGTGTTCGAATTGAAAAAGATTTTTTAGG
TGAAAAAGAAGTACCAAACT

Product: proton/sodium-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVTQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA

Sequences:

>Translated_423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVTQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA
>Mature_423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVTQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=469, Percent_Identity=28.5714285714286, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI40254478, Length=483, Percent_Identity=26.2939958592132, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI21314632, Length=438, Percent_Identity=26.2557077625571, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI194239697, Length=471, Percent_Identity=24.6284501061571, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI66773030, Length=439, Percent_Identity=27.5626423690205, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4827012, Length=287, Percent_Identity=32.7526132404181, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI5032093, Length=428, Percent_Identity=25.4672897196262, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI262359914, Length=404, Percent_Identity=27.2277227722772, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI223468566, Length=273, Percent_Identity=27.4725274725275, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI223468564, Length=273, Percent_Identity=27.4725274725275, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI301601644, Length=200, Percent_Identity=30.5, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=54.8463356973995, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=42.0792079207921, Blast_Score=334, Evalue=8e-93,
Organism=Escherichia coli, GI1788024, Length=400, Percent_Identity=29.25, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789473, Length=340, Percent_Identity=25.8823529411765, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=28.2296650717703, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI193206505, Length=451, Percent_Identity=27.2727272727273, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=441, Percent_Identity=27.437641723356, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71983106, Length=441, Percent_Identity=27.437641723356, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=487, Percent_Identity=26.8993839835729, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI193206654, Length=426, Percent_Identity=26.5258215962441, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17541374, Length=420, Percent_Identity=27.3809523809524, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583025, Length=441, Percent_Identity=26.530612244898, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17137668, Length=441, Percent_Identity=26.530612244898, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24583023, Length=441, Percent_Identity=26.530612244898, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI281360481, Length=447, Percent_Identity=25.2796420581655, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360483, Length=447, Percent_Identity=24.8322147651007, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137666, Length=447, Percent_Identity=24.8322147651007, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45286; Mature: 45286

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]