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The map label for this gene is mprF [H]

Identifier: 49184392

GI number: 49184392

Start: 1405722

End: 1408307

Strand: Reverse

Name: mprF [H]

Synonym: BAS1375

Alternate gene names: 49184392

Gene position: 1408307-1405722 (Counterclockwise)

Preceding gene: 49184407

Following gene: 49184389

Centisome position: 26.93

GC content: 36.04

Gene sequence:

>2586_bases
ATGTCGTTTTCATGGAAACGTTTCTTACAAATCGGGAAAATTATCTTCCCATTTGTTGTATTAACAATTGTATTCTTTCA
AGCAAAAAAAGAATTAGCAGGCATTTCTTTTTTAGAAGCAATCAATACAATTAAAAACATTCCAACCGGAGGAGTCTTTT
TAGCAATTACACTTGGTGCATTTGCCGTATCCACAATGTTCTTTTATGACTATGTTATGCTTCGTTATTTAAAAGCTGAT
ATACCAGTCCAAAAGATTTTTCGTATCTCATGGATTGCTAATACCTTAAATGGATTTATTGGATTTGGTGGTCTCGTTGG
AGCAGGTGTACGCACAATGCTGTATCGTCCATACATAAAAGAAAATGGCAAACTTATTAAAAGTATCGCTTGGATGACAA
CCGCTTTTATTAACGGACTAGCTATTCTTTCGTTCCTCGGTCTTATCGGAATATTAGACACAAGTTTTATTTTGCATGAA
AAACCGTGGCTATGGCCTGTTCTTATCTTCTTCGCTCTTTTCGTCCCTATATACATTGGCTTCTCTAAACTAAAAAATAG
AAAAACGAAGCAAGCGGAAGGACAAGATGAAGGAGAAGAAGAGAAAAATCCAACTGTTTTATACTCATTAGTTTCATTAG
TTGAGTGGGTATCTGCTGGTATTGTTATGTACGTCATATTAATATTATTTGGGATCGATATCGAATTTCAAAAGTTTTTA
GGTGTGTATGTAATTGCTGCTTTAGCTGGCGTTGTTAGTCTTGTTCCTGGTGGACTGGGTTCATTTGATCTTGTCTTTTT
AACTGGACTTGGACAATACGGCATTGATACAGGCGTATTACTACCTGCTATGTTATTATATCGCCTTGTCTATTACATTT
TACCGTTCTGCCTTGGTCTTATTTTTGCAGCTTTTGAAATGACAGGTGTGGCCATTAAAAAGTTTGAAGATAAGCCTTTT
ATTGCGCCTGCATTAGAAACAACTGGTGTTATATGGACTTTGCAGCGTGATTTTCTAGGAAAACTAGGTTCATGGGCCTC
TGCTGCTTTAACAGTATTTGCTGGACTAATGGTTATTTTATCGACCATTCTACCAACAAGTATAAACAGAGCACACGCCT
TACATATTCTAGCTCCAAAACATCTTATTCAATTTTCTTTTAGCTTATCACTAACATTTGGTATTCTCCTCCTGATCCTT
TCACGAGGCATATATTATGGAACAAAGCGTTCTTACTATATGACGATTATTTCTTTAATCGGAGCAGCCGTCTTTAATAC
GCTAAAAGGGATTGATATTGAAGAAACGTTTATTTTATTAATCGTACTCGCTGTATTATATATGCTTCGTAAAAGATTTG
TACGCGAGAAAATGGAAGTCTCACTTTCTGATATCGTAAAAGTTTTTATATTCTTACTTATAACTTTATATTTATATAAA
AACTTAGGTATTTTATTTGCAGGTGCAAAAGAAGCTTTTAAACCTGATTTTGTCGTTCGTAATATTACGCAAGTGAAACG
AAGTGCATTAGCTGCTGCCTTTTTCGTTCCTACATTTTTACTGATTGGCTCACTCATTGCTAATCGTTATCGAAATGAAT
TTCCCGGGCAACCAGCTAATGATAAAAGATTGCAAAACTTTTTAGATGAACATGGCGGAAATGTACTTAGTCATTTAGGA
TTTTTAGGTGATAAACAATTCTTCTTCAGTAGCGATGGGAAAGCGCTCCTTCTCTTCTCTATAACTGGAAAACGTCTTGT
TGTGCTAGGTGATCCAATTGGAGATCCTTCCTCCTACCGTACTGTGTTACAGGAGTTTTTAGCTGAGGCTGATCGATTTG
GATACATTTGTGTATTCTACCAAATCGAAAGTAAATGGATGAGTTTATATCATGATTTCGGTTACAACTTCTTTAAGCTT
GGTGAAGAAGCTGTCGTTGATTTGAACACATTTACAATAACAGGAAAAAAACGCGCCGGTATGCGAGCAACTTTCAACCG
TTTTGAACGAGAGGGCTATACATTCTCTATTCACCAGCCACCGTTCTCAAACGAATTATTTGAAGAATTACGAAAAGTTT
CAGATGCGTGGCTCGGTGGAAAAAAAGAGAAAAGTTTCTCACTCGGATACTTTGATCATGAATATATTAACCGAGCACCT
ATCGCTACATTATCTGATGCAGATGGAAAAATCATCGCATTTACAACTTTTATGCCAGTATATCAAGACGGATCATTGTC
TGTTGATTTAATGCGGTATTATCCAGATGCACCTAGCGGCATTATGGATGCCATTTTCATCCACCTATTCCAGTGGGCAA
AAGAAAATGAATACCACTCCTTTAATATTGGCATGGCGCCACTTTCAAATGTAGGTTTATCGACACAATCTTTCTGGTCT
GAACGAGTTGCCGCTGCCATCTTTAATAATGTTCGTTATACATATAGTTTCAGCGGGTTACGACATTTTAAAGAAAAATA
TAAACCAGCATGGAGCGGTAAATATTTAGCATTTAGAAAGAATCATTCTTTACCAATTACAATGCTCTCTGTAACAAAAT
TAATAGGAAAAAGAAAAAACAGCTAA

Upstream 100 bases:

>100_bases
AAATAGCTTCCTTATACAGGAATTTACCTTTTTATTTTTCTTGAAGTTTGTCATAATAATATTATTGTCTCAGTTTTCTT
ATACAAGGAGAGTTGTATTT

Downstream 100 bases:

>100_bases
ATAGTTAGCTGTTTTTTCTTTTTTGAACTTGTACAATGAATTCTTTTTCATATTTCTTTCCATTTATATAGAAATCTCCC
CATATTTTATACGTTCCTTC

Product: virulence factor MprF

Products: NA

Alternate protein names: Lysylphosphatidylglycerol synthase; LPG synthase [H]

Number of amino acids: Translated: 861; Mature: 860

Protein sequence:

>861_residues
MSFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKAD
IPVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHE
KPWLWPVLIFFALFVPIYIGFSKLKNRKTKQAEGQDEGEEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFL
GVYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPF
IAPALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLIL
SRGIYYGTKRSYYMTIISLIGAAVFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYK
NLGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLG
FLGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKL
GEEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSNELFEELRKVSDAWLGGKKEKSFSLGYFDHEYINRAP
IATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWS
ERVAAAIFNNVRYTYSFSGLRHFKEKYKPAWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS

Sequences:

>Translated_861_residues
MSFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKAD
IPVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHE
KPWLWPVLIFFALFVPIYIGFSKLKNRKTKQAEGQDEGEEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFL
GVYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPF
IAPALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLIL
SRGIYYGTKRSYYMTIISLIGAAVFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYK
NLGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLG
FLGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKL
GEEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSNELFEELRKVSDAWLGGKKEKSFSLGYFDHEYINRAP
IATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWS
ERVAAAIFNNVRYTYSFSGLRHFKEKYKPAWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS
>Mature_860_residues
SFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKADI
PVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHEK
PWLWPVLIFFALFVPIYIGFSKLKNRKTKQAEGQDEGEEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFLG
VYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPFI
APALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLILS
RGIYYGTKRSYYMTIISLIGAAVFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYKN
LGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLGF
LGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKLG
EEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSNELFEELRKVSDAWLGGKKEKSFSLGYFDHEYINRAPI
ATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWSE
RVAAAIFNNVRYTYSFSGLRHFKEKYKPAWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS

Specific function: Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contribu

COG id: COG2898

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LPG synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR022791 [H]

Pfam domain/function: PF03706 UPF0104 [H]

EC number: =2.3.2.3 [H]

Molecular weight: Translated: 97014; Mature: 96883

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH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CCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]