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The map label for this gene is trpE [H]

Identifier: 49184175

GI number: 49184175

Start: 1203111

End: 1204538

Strand: Direct

Name: trpE [H]

Synonym: BAS1156

Alternate gene names: 49184175

Gene position: 1203111-1204538 (Clockwise)

Preceding gene: 49184174

Following gene: 49184176

Centisome position: 23.01

GC content: 39.15

Gene sequence:

>1428_bases
GTGAAAGGCATGATGACAAAAGAGGAATTTATAAAACAGAAAGAACAAAGAAAAACATTTTTGGTAATCGCTGAAGAAGA
AGGAGATAGCATTACGCCAATTTCTTTATATAGACGTATGAAAGGTAAAAAGAAATTTTTATTAGAAAGCTCACAGCTTC
ATCAAGATAAAGGGCGTTATTCTTACTTAGGTTGTAATCCATATGGTGAAGTGAAAAGCGTTGGTACGGAAGTGGAACGA
ACGATTTACGGCAGGGCAGAAAAGTTGCAAAGTAACGTACTACAAGTGTTAGAAGAAATAATCGCACCATCACAAGTAGA
CAGTCCATTTCCATTTTGCGGAGGAGCAGTTGGATACATTGGCTATGACGTCATTCGGCAATATGAAAACATTGGAGCAG
ATTTACATGATCCATTGAATATTCCAGAAGTACACCTTTTACTGTACCGTGAGTTTATCGTGTATGACCACTTACGCCAA
AAGTTGTCGTTTGTATATGTATGCAGGGAAGATGATTCAGCAGATTATGAAGAAGTATACGAAAGGCTGCGAGTATACAA
AGAGGAAGTGCTACAGGGAGAAGAAGCGGAAGTAACTGAAATAAGATCAACATTATCATTCACTTCTTCTATAACGGAAA
GAGAATTTTGCGTGATGGTAGAAACGGCGAAAGAACACATCGGGGCCGGGGACATATTTCAAGTTGTATTATCTCAGCGT
TTGCAAAGCGAATGTATTGGAGATCCATTCGCGTTATATCGAAAACTTCGAATTGCCAATCCATCACCATATATGTTTTA
TATCGATTTTCAAGATTATGTTGTACTCGGTTCTTCGCCAGAAAGTTTGTTATCAGTAAGGGAGGATAAAGTGATGACGA
ATCCAATTGCTGGTACGAGGCCGAGAGGGAAAACGAAGGAGGAAGATACGGAGATTGAAAAAGAACTGTTAGAAAATGAG
AAAGAGCGAGCGGAGCATATGATGCTTGTAGATCTTGGGCGAAATGATATTGGTAGAGTGAGTGAAATCGGCTCAGTTAC
GATAGATAAATATATGAAAGTAGAAAAATATTCTCACGTTATGCACATTGTATCTGAAGTTTACGGAACATTGCGAAAAC
AAATGAGCGGATTTGATGCATTAGCGTACTGTTTACCAGCGGGGACGGTATCAGGTGCTCCGAAAATTAGAGCGATGGAA
ATTATAAATGAGCTAGAGAATGAAAAAAGAAATGTGTACGCCGGTGCAGTTGGATACGTTAGTTTTTCAGGGAATCTTGA
TATGGCGCTCGCCATTCGAACAATGGTTGTAAAGGATGAAAAAGCATACGTTCAGGCAGGAGCGGGTATTGTTTACGATT
CAGATCCAGTAGCTGAATATGAAGAAACATTAAATAAAGCGAGAGCGCTATTGGAGGTAATGAAATGA

Upstream 100 bases:

>100_bases
CGGGATGCTTTTGCGTCCAACATGAGGTGGTACCACGGTAAATTTATCGTCCTCTACATATTTTCGATATGTAGAGGACT
TTTTTATTTTTCAGGATGAG

Downstream 100 bases:

>100_bases
TTGTACTGATCGATAATTATGATTCATTCACATATAACTTGTATCAACTATTAGGCGAATACGAAGAAGAAATTGTTGTC
GTAAGAAATGATCAAATAAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKGMMTKEEFIKQKEQRKTFLVIAEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVER
TIYGRAEKLQSNVLQVLEEIIAPSQVDSPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQ
KLSFVYVCREDDSADYEEVYERLRVYKEEVLQGEEAEVTEIRSTLSFTSSITEREFCVMVETAKEHIGAGDIFQVVLSQR
LQSECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKEEDTEIEKELLENE
KERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLRKQMSGFDALAYCLPAGTVSGAPKIRAME
IINELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGIVYDSDPVAEYEETLNKARALLEVMK

Sequences:

>Translated_475_residues
MKGMMTKEEFIKQKEQRKTFLVIAEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVER
TIYGRAEKLQSNVLQVLEEIIAPSQVDSPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQ
KLSFVYVCREDDSADYEEVYERLRVYKEEVLQGEEAEVTEIRSTLSFTSSITEREFCVMVETAKEHIGAGDIFQVVLSQR
LQSECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKEEDTEIEKELLENE
KERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLRKQMSGFDALAYCLPAGTVSGAPKIRAME
IINELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGIVYDSDPVAEYEETLNKARALLEVMK
>Mature_475_residues
MKGMMTKEEFIKQKEQRKTFLVIAEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRYSYLGCNPYGEVKSVGTEVER
TIYGRAEKLQSNVLQVLEEIIAPSQVDSPFPFCGGAVGYIGYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQ
KLSFVYVCREDDSADYEEVYERLRVYKEEVLQGEEAEVTEIRSTLSFTSSITEREFCVMVETAKEHIGAGDIFQVVLSQR
LQSECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTRPRGKTKEEDTEIEKELLENE
KERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHVMHIVSEVYGTLRKQMSGFDALAYCLPAGTVSGAPKIRAME
IINELENEKRNVYAGAVGYVSFSGNLDMALAIRTMVVKDEKAYVQAGAGIVYDSDPVAEYEETLNKARALLEVMK

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=436, Percent_Identity=30.9633027522936, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1787518, Length=373, Percent_Identity=38.3378016085791, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1786809, Length=292, Percent_Identity=27.3972602739726, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082077, Length=313, Percent_Identity=26.517571884984, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=442, Percent_Identity=41.1764705882353, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324361, Length=407, Percent_Identity=25.5528255528256, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54023; Mature: 54023

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGMMTKEEFIKQKEQRKTFLVIAEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRY
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCE
SYLGCNPYGEVKSVGTEVERTIYGRAEKLQSNVLQVLEEIIAPSQVDSPFPFCGGAVGYI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
GYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLSFVYVCREDDSADYEEVY
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHH
ERLRVYKEEVLQGEEAEVTEIRSTLSFTSSITEREFCVMVETAKEHIGAGDIFQVVLSQR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHCCCHHHHHHHHHHH
LQSECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTR
HHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCC
PRGKTKEEDTEIEKELLENEKERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHV
CCCCCCCHHHHHHHHHHHCHHHHHHHEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHH
MHIVSEVYGTLRKQMSGFDALAYCLPAGTVSGAPKIRAMEIINELENEKRNVYAGAVGYV
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEE
SFSGNLDMALAIRTMVVKDEKAYVQAGAGIVYDSDPVAEYEETLNKARALLEVMK
EECCCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKGMMTKEEFIKQKEQRKTFLVIAEEEGDSITPISLYRRMKGKKKFLLESSQLHQDKGRY
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCE
SYLGCNPYGEVKSVGTEVERTIYGRAEKLQSNVLQVLEEIIAPSQVDSPFPFCGGAVGYI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
GYDVIRQYENIGADLHDPLNIPEVHLLLYREFIVYDHLRQKLSFVYVCREDDSADYEEVY
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHH
ERLRVYKEEVLQGEEAEVTEIRSTLSFTSSITEREFCVMVETAKEHIGAGDIFQVVLSQR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHCCCHHHHHHHHHHH
LQSECIGDPFALYRKLRIANPSPYMFYIDFQDYVVLGSSPESLLSVREDKVMTNPIAGTR
HHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCC
PRGKTKEEDTEIEKELLENEKERAEHMMLVDLGRNDIGRVSEIGSVTIDKYMKVEKYSHV
CCCCCCCHHHHHHHHHHHCHHHHHHHEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHH
MHIVSEVYGTLRKQMSGFDALAYCLPAGTVSGAPKIRAMEIINELENEKRNVYAGAVGYV
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEE
SFSGNLDMALAIRTMVVKDEKAYVQAGAGIVYDSDPVAEYEETLNKARALLEVMK
EECCCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]