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The map label for this gene is ygcA [C]

Identifier: 49183442

GI number: 49183442

Start: 445990

End: 447369

Strand: Direct

Name: ygcA [C]

Synonym: BAS0414

Alternate gene names: 49183442

Gene position: 445990-447369 (Clockwise)

Preceding gene: 49183441

Following gene: 49183445

Centisome position: 8.53

GC content: 36.59

Gene sequence:

>1380_bases
ATGATACAAAAGCAACATGAGAGTAAGTTGGAAGTTGGTCAAACATTTCCTGTGACAATTAAACGTCTTGGGATTAACGG
AGAAGGCGTTGGTTATTTTAAGAGACAAGTTGTTTTCATTCCAGGGGCATTACCAGGAGAAGAAGTTGTTGCTGAAACAA
CGAAAATTCAGCGTGGTTTCGCAGAAGCGAAAGTGAAAAAAGTTCGTAAAGCTTCACCGCATCGTGTGAAAGCACCGTGT
CCAGTATATGAGGAGTGTGGCGGTTGTCAGCTGCAACATTTAGATTATAAAGAACAATTGAATCAAAAGCGTGATATCGT
TGTACAAGCATTTGAGAAATACATGAAAAACAGTATGGAAGAGAAAATTCGTCCAACGCTTGGCATGGAAAATCCATGGC
ATTATCGTAATAAGAGTCAATTACAAGTGGGGCGTAAAGACGAAAAGGTTATTACAGGGCTGTATAAACAAAATTCACAT
CAGTTAATTGATATTGCTCATTGTATGATTCAACATAAAGCAACGAATGAAGCGACAAAAGTTGTAAGACGTATTTTAGA
AAAATTAAATGTTTCTATTTACAATGAGAAAAAACAAAAAGGTTTAGTACGTACAATTGTGACACGTACTGCAGTTCAAA
CAGGGGAAGTACAAGTTACACTTATTACAACAAAAGAAGAGTTGCCAAATAAAGAACAATTTATTGCAGAAGTACAAAAA
CAGATGCCAGCTGTTAAATCAATTATGCAAAATGTAAACTGGCGTAAAACATCTGTTATTTTCGGAGATAAAACATTTAA
ATTAGCTGGAAAAGAAGTAATTCAAGAAACACTTGGTGATTTATCATTTGAATTATCAGCACGTGCATTCTTCCAGTTGA
ATCCAGAACAAACGGTTGTATTATATAATGAAGCGAAAAAAGCCGCTGCTTTAACAGGAAATGAGAAAATTGTAGATGCA
TATTGTGGTGTTGGTACAATCGGTCTTTGGCTTGCGAATGATGCAGCGGAAGTACGTGGTATGGATGTAATTCCAGAAGC
AATTGCAGATGCAAGAAAAAATGCGAAGCGTCACGGATTTACAAATACGAAATATGAAGCAGGTAAAGCTGAACAATGGT
TACCTAAATGGGTAAAAGAAGGATGGCGTCCAGATGTAATTGTTGTCGATCCACCACGTACAGGTTGCGACGATAAATTA
CTGGAAACAATTTTAAAAGTGAAGCCAAAACAAGTTGTTTACGTATCTTGTAACCCTTCTTCATTAGCACGTGATGTACA
AGCGTTAATGAAGAGTTATGAAGTGGAATATGTACAACCAGTTGATATGTTCCCGCATACAGCTCATGTTGAGAACGTAG
TTAAATTAACGCTGAAATAA

Upstream 100 bases:

>100_bases
CCTGATGATGCATTTTTAGAAAAAGTGAAACAAGAGTGTGAACCATACTGCAGTTATGCAGCGTTATATTTATGGAAAAG
TATAGAGTAGAGGTGTAATA

Downstream 100 bases:

>100_bases
AGGGGTTTCAATGAAATTGTTGATGGGTTTGACCACATTCTGACCACATCAACAATTTTTTTATGATTTTAATGCCTCAC
TTAGCTTTAAAACAGCACTT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MIQKQHESKLEVGQTFPVTIKRLGINGEGVGYFKRQVVFIPGALPGEEVVAETTKIQRGFAEAKVKKVRKASPHRVKAPC
PVYEECGGCQLQHLDYKEQLNQKRDIVVQAFEKYMKNSMEEKIRPTLGMENPWHYRNKSQLQVGRKDEKVITGLYKQNSH
QLIDIAHCMIQHKATNEATKVVRRILEKLNVSIYNEKKQKGLVRTIVTRTAVQTGEVQVTLITTKEELPNKEQFIAEVQK
QMPAVKSIMQNVNWRKTSVIFGDKTFKLAGKEVIQETLGDLSFELSARAFFQLNPEQTVVLYNEAKKAAALTGNEKIVDA
YCGVGTIGLWLANDAAEVRGMDVIPEAIADARKNAKRHGFTNTKYEAGKAEQWLPKWVKEGWRPDVIVVDPPRTGCDDKL
LETILKVKPKQVVYVSCNPSSLARDVQALMKSYEVEYVQPVDMFPHTAHVENVVKLTLK

Sequences:

>Translated_459_residues
MIQKQHESKLEVGQTFPVTIKRLGINGEGVGYFKRQVVFIPGALPGEEVVAETTKIQRGFAEAKVKKVRKASPHRVKAPC
PVYEECGGCQLQHLDYKEQLNQKRDIVVQAFEKYMKNSMEEKIRPTLGMENPWHYRNKSQLQVGRKDEKVITGLYKQNSH
QLIDIAHCMIQHKATNEATKVVRRILEKLNVSIYNEKKQKGLVRTIVTRTAVQTGEVQVTLITTKEELPNKEQFIAEVQK
QMPAVKSIMQNVNWRKTSVIFGDKTFKLAGKEVIQETLGDLSFELSARAFFQLNPEQTVVLYNEAKKAAALTGNEKIVDA
YCGVGTIGLWLANDAAEVRGMDVIPEAIADARKNAKRHGFTNTKYEAGKAEQWLPKWVKEGWRPDVIVVDPPRTGCDDKL
LETILKVKPKQVVYVSCNPSSLARDVQALMKSYEVEYVQPVDMFPHTAHVENVVKLTLK
>Mature_459_residues
MIQKQHESKLEVGQTFPVTIKRLGINGEGVGYFKRQVVFIPGALPGEEVVAETTKIQRGFAEAKVKKVRKASPHRVKAPC
PVYEECGGCQLQHLDYKEQLNQKRDIVVQAFEKYMKNSMEEKIRPTLGMENPWHYRNKSQLQVGRKDEKVITGLYKQNSH
QLIDIAHCMIQHKATNEATKVVRRILEKLNVSIYNEKKQKGLVRTIVTRTAVQTGEVQVTLITTKEELPNKEQFIAEVQK
QMPAVKSIMQNVNWRKTSVIFGDKTFKLAGKEVIQETLGDLSFELSARAFFQLNPEQTVVLYNEAKKAAALTGNEKIVDA
YCGVGTIGLWLANDAAEVRGMDVIPEAIADARKNAKRHGFTNTKYEAGKAEQWLPKWVKEGWRPDVIVVDPPRTGCDDKL
LETILKVKPKQVVYVSCNPSSLARDVQALMKSYEVEYVQPVDMFPHTAHVENVVKLTLK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=346, Percent_Identity=28.6127167630058, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI51173878, Length=346, Percent_Identity=28.6127167630058, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI269784678, Length=384, Percent_Identity=26.0416666666667, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI269784680, Length=207, Percent_Identity=31.8840579710145, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI269784676, Length=207, Percent_Identity=31.8840579710145, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI20149688, Length=207, Percent_Identity=31.8840579710145, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1789148, Length=457, Percent_Identity=26.6958424507659, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787083, Length=383, Percent_Identity=25.065274151436, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1790403, Length=211, Percent_Identity=26.0663507109005, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997438, Length=163, Percent_Identity=32.5153374233129, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=466, Percent_Identity=24.4635193133047, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666579, Length=440, Percent_Identity=28.6363636363636, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y426_BACAN (Q81Z48)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_842968.1
- RefSeq:   YP_017052.1
- RefSeq:   YP_026694.1
- ProteinModelPortal:   Q81Z48
- EnsemblBacteria:   EBBACT00000008947
- EnsemblBacteria:   EBBACT00000018008
- EnsemblBacteria:   EBBACT00000024397
- GeneID:   1087369
- GeneID:   2819883
- GeneID:   2849334
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_0426
- KEGG:   bar:GBAA_0426
- KEGG:   bat:BAS0414
- TIGR:   BA_0426
- TIGR:   GBAA_0426
- GeneTree:   EBGT00050000002272
- HOGENOM:   HBG690163
- OMA:   RTVMIRR
- ProtClustDB:   CLSK886880
- BioCyc:   BANT260799:BAS0414-MONOMER
- BioCyc:   BANT261594:GBAA0426-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 51967; Mature: 51967

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 417-417 BINDING 292-292 BINDING 321-321 BINDING 342-342 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKQHESKLEVGQTFPVTIKRLGINGEGVGYFKRQVVFIPGALPGEEVVAETTKIQRGF
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
AEAKVKKVRKASPHRVKAPCPVYEECGGCQLQHLDYKEQLNQKRDIVVQAFEKYMKNSME
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEECCCHHHHHCHHHHHHHHHHHHHHHHHHH
EKIRPTLGMENPWHYRNKSQLQVGRKDEKVITGLYKQNSHQLIDIAHCMIQHKATNEATK
HHHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHH
VVRRILEKLNVSIYNEKKQKGLVRTIVTRTAVQTGEVQVTLITTKEELPNKEQFIAEVQK
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHHEECCCEEEEEEECHHHCCCHHHHHHHHHH
QMPAVKSIMQNVNWRKTSVIFGDKTFKLAGKEVIQETLGDLSFELSARAFFQLNPEQTVV
HHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEE
LYNEAKKAAALTGNEKIVDAYCGVGTIGLWLANDAAEVRGMDVIPEAIADARKNAKRHGF
EEECCCHHHHCCCCCCCHHHHCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCCC
TNTKYEAGKAEQWLPKWVKEGWRPDVIVVDPPRTGCDDKLLETILKVKPKQVVYVSCNPS
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHH
SLARDVQALMKSYEVEYVQPVDMFPHTAHVENVVKLTLK
HHHHHHHHHHHHCCCCEECCHHCCCCHHHHHHHEEEECC
>Mature Secondary Structure
MIQKQHESKLEVGQTFPVTIKRLGINGEGVGYFKRQVVFIPGALPGEEVVAETTKIQRGF
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
AEAKVKKVRKASPHRVKAPCPVYEECGGCQLQHLDYKEQLNQKRDIVVQAFEKYMKNSME
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEECCCHHHHHCHHHHHHHHHHHHHHHHHHH
EKIRPTLGMENPWHYRNKSQLQVGRKDEKVITGLYKQNSHQLIDIAHCMIQHKATNEATK
HHHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHH
VVRRILEKLNVSIYNEKKQKGLVRTIVTRTAVQTGEVQVTLITTKEELPNKEQFIAEVQK
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHHEECCCEEEEEEECHHHCCCHHHHHHHHHH
QMPAVKSIMQNVNWRKTSVIFGDKTFKLAGKEVIQETLGDLSFELSARAFFQLNPEQTVV
HHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEE
LYNEAKKAAALTGNEKIVDAYCGVGTIGLWLANDAAEVRGMDVIPEAIADARKNAKRHGF
EEECCCHHHHCCCCCCCHHHHCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCCC
TNTKYEAGKAEQWLPKWVKEGWRPDVIVVDPPRTGCDDKLLETILKVKPKQVVYVSCNPS
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHH
SLARDVQALMKSYEVEYVQPVDMFPHTAHVENVVKLTLK
HHHHHHHHHHHHCCCCEECCHHCCCCHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629