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The map label for this gene is ygcA [C]

Identifier: 49183346

GI number: 49183346

Start: 342491

End: 343867

Strand: Direct

Name: ygcA [C]

Synonym: BAS0318

Alternate gene names: 49183346

Gene position: 342491-343867 (Clockwise)

Preceding gene: 49183341

Following gene: 49183347

Centisome position: 6.55

GC content: 39.94

Gene sequence:

>1377_bases
ATGAGTACAAAAATGACGCCACCAGTTGAAAAAAACGAGTTTATAGATGTAGTATTTGAAGATTTAACACATGATGGTGC
CGGTGTTGCGAAAGTAAAAGGCTATCCTATTTTCGTTAAAAACGGATTACCAGGTGAAGAAGCGCAAATTAAAATTGTTA
AAGTGAAGAAAAACTTCGCATTCGGACGTTTAATGAAACTTCATACAGAGAGCCCATATCGTAAAGATGCAGAATGCCCA
GTGTACAATCAGTGCGGCGGTTGTCAGCTTCAGCATTTAACATATGAAGGACAATTACAAGCGAAAGAAAAACAAGTACG
TGACGTTATGCAGCGTATTGGCGGATTAGGTGATGTTCCTGTTCATCCTGTACTTGGCATGAAGAATCCGTGGGTATACC
GTAATAAAGCACAAGTACCAATTGGAGAACGTGAGGGCGGACTTGTAGCTGGTTTCTATCGTCAAGGAACGCATGACATT
ATTAATATGGAATCATGTTTAATTCAAGCAGAAGAAAACGATACATTGATTCAAGAAGTAAAACGTATTTGTGAAAAACA
CGGTATTTCGGCGTATAACGAAGAGCGTAACAAAGGGACACTTCGCCACGTAATGGCTCGTTACGGACAAGTAACAGGGG
AAATTATGCTTGTCTTCATTACTCGTACAGCAGAACTGCCAAACAAAAAAGCAATCATTGAAGAAATTGCCGCGAAATTC
CCAGAAGTAAAATCAATTGTTCAAAACGTAAACCCGAAACGTACAAACGTAATTTTCGGAGACAAAACGACAGTACTGTA
CGGATCAGAATATATTTATGACTTTATCGGGGATATTAAGTTTGCGATTTCAGCACGTTCATTCTATCAAGTAAACCCAG
AGCAAACGAAAGTGTTATACGATAAAACGTTAGAATACGCCAAATTAGATGGCAACGAAACAGTAATTGATGCCTATTGC
GGAATTGGATCAATCTCCTTATTCCTAGCACAAAAAGCGAAAAAAGTATACGGCGTTGAAATTGTGCCAGAAGCAATCGA
AGACGCGAAGCGTAACGCAGCGCTAAACAATATGACAAACGCTGAATTTGGTGTAGGAGAAGCAGAAGTAGTCATTCCAA
AATGGTATAAAGAAGGCGTAATAGCTGACACAATGGTCGTAGATCCACCGCGTAAAGGTTGTGATGAGGCACTACTTAAC
ACAATCATCGACATGAAACCAAAACGCGTCGTATACGTATCATGTAACCCAGCAACATTAGCACGTGACTTAAAAGTACT
AGAAGAAGGCGGATATAAAACGCAGGAAGTACAACTTGTTGATATGTTCCCGCATACGACGCATGTGGAGTGTGTAGCTT
GGCTTAAGTTGGTATAA

Upstream 100 bases:

>100_bases
ACAGAGAACTATCGTCAATAGCTTTTTTTCTTCCAATAGAAATAGACCATATAAGTATGATAAAATGTAACGCAGTGTTA
TGAAAAAGAGAGGTCGGAAA

Downstream 100 bases:

>100_bases
TAAAAAAGCAGTTGATATAGGAAAATCTATACCATCTGCTTTTTGGTTTATTGAGAGTTTGAAATTGTATTCATAGTGAG
AGGATTTGAATTTGAAATGA

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIVKVKKNFAFGRLMKLHTESPYRKDAECP
VYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLGDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDI
INMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
PEVKSIVQNVNPKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYC
GIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLN
TIIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQLVDMFPHTTHVECVAWLKLV

Sequences:

>Translated_458_residues
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIVKVKKNFAFGRLMKLHTESPYRKDAECP
VYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLGDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDI
INMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
PEVKSIVQNVNPKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYC
GIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLN
TIIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQLVDMFPHTTHVECVAWLKLV
>Mature_457_residues
STKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIVKVKKNFAFGRLMKLHTESPYRKDAECPV
YNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLGDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDII
NMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKFP
EVKSIVQNVNPKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYCG
IGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNT
IIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQLVDMFPHTTHVECVAWLKLV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=346, Percent_Identity=26.878612716763, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI51173878, Length=346, Percent_Identity=26.878612716763, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI269784680, Length=205, Percent_Identity=32.1951219512195, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI269784676, Length=205, Percent_Identity=32.1951219512195, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI20149688, Length=205, Percent_Identity=32.1951219512195, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI269784678, Length=205, Percent_Identity=32.1951219512195, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1789148, Length=452, Percent_Identity=30.3097345132743, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787083, Length=386, Percent_Identity=27.2020725388601, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1790403, Length=181, Percent_Identity=30.3867403314917, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71997438, Length=171, Percent_Identity=32.7485380116959, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322909, Length=441, Percent_Identity=25.6235827664399, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24666579, Length=410, Percent_Identity=29.5121951219512, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- InterPro:   IPR003402 [H]

Pfam domain/function: PF02475 Met_10; PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51328; Mature: 51197

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIVKVKKNFA
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEEEECCCC
FGRLMKLHTESPYRKDAECPVYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLGDVP
HHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDIINMESCLIQAEENDTLIQEV
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHEEHHHHEEEECCCCHHHHHH
KRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHC
PEVKSIVQNVNPKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLY
HHHHHHHHCCCCCCCEEEECCCEEEEECCHHHHHHHCCEEEEEEECEEEEECHHHHHHHH
DKTLEYAKLDGNETVIDAYCGIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTN
HHCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHCCCCC
AEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNTIIDMKPKRVVYVSCNPATL
CCCCCCCEEEEEECHHCCCCEECEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLKVLEEGGYKTQEVQLVDMFPHTTHVECVAWLKLV
HHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIVKVKKNFA
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEEEECCCC
FGRLMKLHTESPYRKDAECPVYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLGDVP
HHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDIINMESCLIQAEENDTLIQEV
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHEEHHHHEEEECCCCHHHHHH
KRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHC
PEVKSIVQNVNPKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLY
HHHHHHHHCCCCCCCEEEECCCEEEEECCHHHHHHHCCEEEEEEECEEEEECHHHHHHHH
DKTLEYAKLDGNETVIDAYCGIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTN
HHCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHCCCCC
AEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNTIIDMKPKRVVYVSCNPATL
CCCCCCCEEEEEECHHCCCCEECEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLKVLEEGGYKTQEVQLVDMFPHTTHVECVAWLKLV
HHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA