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The map label for this gene is purM [H]

Identifier: 49183311

GI number: 49183311

Start: 303937

End: 304977

Strand: Direct

Name: purM [H]

Synonym: BAS0283

Alternate gene names: 49183311

Gene position: 303937-304977 (Clockwise)

Preceding gene: 49183310

Following gene: 49183312

Centisome position: 5.81

GC content: 38.62

Gene sequence:

>1041_bases
ATGGCGAATGCATATAAGCAAGCAGGAGTAGATATTGAAGCTGGATATGAAGCGGTATCTCGCATGAAAAAACACGTACA
AACAACTATGAGAAAAGAAGTACTAGGCGGTTTAGGCGGTTTTGGAGGTATGTTTGATCTATCAAAATTTGCATTAGAAG
AACCTGTATTAGTATCTGGAACAGATGGCGTGGGAACGAAATTGATGCTCGCTTTTATGGCAGATAAACATGACACAATT
GGTATTGATGCAGTAGCAATGTGTGTAAATGATATTGTTGTCCAAGGAGCAGAGCCGCTTTTCTTCCTTGATTATATTGC
TTGTGGTAAAGCTGAACCTAGTAAAATTGAAAACATCGTCAAAGGTATATCAGAGGGCTGTCGCCAAGCAGGTTGTGCTT
TAATTGGTGGAGAAACAGCTGAAATGCCAGGAATGTATTCGACGGAAGAATACGATTTAGCTGGTTTTACAGTTGGAATT
GTTGATAAAAAGAAAATTGTAACAGGTGAAAAAATTGAAGCTGGTCACGTATTAATCGGCTTAGCATCTAGCGGTATTCA
TAGTAATGGTTACTCTTTAGTACGAAAAGTATTACTAGAAGATGGAGAACTATCTTTAGACCGCATTTATGGACGCTTAG
AGCTACCTCTTGGTGAAGAATTATTAAAACCAACGAAAATTTATGTCAAACCTATTTTAGAACTATTGAAGAATCATGAA
GTATACGGTATGGCGCATATTACAGGTGGCGGATTCATTGAAAATATTCCACGTATGTTACCAGAAGGAATCGGTGCAGA
AATTGAATTAGGATCTTGGAAAATTCAGCCGATCTTCAGTTTACTTCAAGAAGTTGGAAAGCTAGAAGAGAAAGAAATGT
TCAATATTTTTAACATGGGTATTGGTATGGTAGTAGCAGTGAAGGAAGAAGATGCAAAAGATATCGTCCGTCTCCTTGAA
GAGCAAGGGGAAACAGCTCGTATTATTGGACGTACTGTACAAGGAGCTGGCGTTACCTTCAATGGGGGCAAAGCACTATG
A

Upstream 100 bases:

>100_bases
TGAAAAAAGCTTCTACTTCTTTTGATGTAGAAGCTAGCTTCTTTTTTATAAATAGCCCGCCCTGGATGGGGAGAAATTAA
AAGACGAGGTGTAAATAACG

Downstream 100 bases:

>100_bases
GTAGATTAGCAGTTTTTGCTTCTGGAAGCGGATCTAACTTTCAATCTCTCGTTAATGCGGTAGAAGAAAAAAGATTGGAT
GCAGAAATTAGTTTATTAGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGI
VDKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHE
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDIVRLLE
EQGETARIIGRTVQGAGVTFNGGKAL

Sequences:

>Translated_346_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGI
VDKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHE
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDIVRLLE
EQGETARIIGRTVQGAGVTFNGGKAL
>Mature_345_residues
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTIG
IDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIV
DKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHEV
YGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDIVRLLEE
QGETARIIGRTVQGAGVTFNGGKAL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=49.4011976047904, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=49.4011976047904, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=49.4011976047904, Blast_Score=326, Evalue=2e-89,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=54.2682926829268, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17567511, Length=333, Percent_Identity=40.8408408408408, Blast_Score=238, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=333, Percent_Identity=44.7447447447448, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=41.5492957746479, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37257; Mature: 37126

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHH
KGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEE
LASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHE
EECCCCCCCHHHHHHHHHHCCCCCCHHHHHCEECCCCCHHHHCHHHHHHHHHHHHHHCCC
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMG
EEEEEEECCCHHHHHHHHHHHCCCCCEEEECCEEHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEEDAKDIVRLLEEQGETARIIGRTVQGAGVTFNGGKAL
CEEEEEECCCCHHHHHHHHHHCCCEEEHHHHEECCCCEEECCCCCC
>Mature Secondary Structure 
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHH
KGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEE
LASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHE
EECCCCCCCHHHHHHHHHHCCCCCCHHHHHCEECCCCCHHHHCHHHHHHHHHHHHHHCCC
VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMG
EEEEEEECCCHHHHHHHHHHHCCCCCEEEECCEEHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEEDAKDIVRLLEEQGETARIIGRTVQGAGVTFNGGKAL
CEEEEEECCCCHHHHHHHHHHCCCEEEHHHHEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA