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The map label for this gene is groEL

Identifier: 49183285

GI number: 49183285

Start: 258879

End: 260513

Strand: Direct

Name: groEL

Synonym: BAS0253

Alternate gene names: 49183285

Gene position: 258879-260513 (Clockwise)

Preceding gene: 49183284

Following gene: 49183286

Centisome position: 4.95

GC content: 41.77

Gene sequence:

>1635_bases
ATGGCAAAAGATATTAAATTTAGTGAAGAAGCACGTCGTTCGATGCTTCGCGGTGTCGACACTCTTGCAAATGCAGTAAA
AGTAACGCTTGGACCAAAAGGTCGTAACGTTGTTCTTGAGAAAAAATTCGGTTCACCACTTATTACAAATGACGGTGTAA
CAATCGCAAAAGAAATTGAATTAGAAGATGCATTCGAAAACATGGGTGCGAAATTAGTAGCAGAAGTTGCTAGCAAAACA
AATGATGTAGCTGGTGACGGAACAACAACTGCAACTGTATTAGCACAAGCTATGATTCGTGAAGGTCTTAAAAACGTAAC
AGCTGGTGCGAACCCAATGGGTCTTCGTAAAGGTATCGAAAAAGCTGTAGTTGCTGCAGTAGAAGAATTAAAAACGATTT
CTAAACCAATCGAAGGTAAATCTTCTATCGCACAAGTAGCTGCTATTTCTGCTGCTGACGAAGAAGTAGGTCAATTAATC
GCTGAAGCAATGGAGCGCGTTGGTAACGACGGCGTTATTACTTTAGAAGAATCTAAAGGTTTCACAACAGAATTAGACGT
AGTAGAAGGTATGCAATTTGATCGTGGATATGCATCTCCTTACATGATTACTGATTCTGACAAAATGGAAGCAGTTCTTG
ATAACCCATACATCTTAATCACTGACAAAAAGATTTCTAACATTCAAGAAATCTTACCAGTATTAGAGCAAGTGGTACAA
CAAGGTAAACCGCTTCTTATCATTGCTGAAGATGTAGAAGGCGAAGCATTAGCTACATTAGTAGTGAACAAACTTCGTGG
TACATTCAATGTAGTAGCTGTTAAAGCTCCTGGATTTGGTGACCGTCGTAAAGCAATGCTAGAAGATATCGCAATCTTAA
CTGGTGGCGAAGTAATCACTGAAGAATTAGGCCGTGACTTAAAATCTGCTACAGTTGAATCTTTAGGACGCGCTGGTAAA
GTTGTTGTAACGAAAGAAAACACAACTGTAGTTGAAGGTGTAGGAAGCACAGAACAAATCGAAGCTCGCATCGGTCAAAT
CCGTGCGCAATTAGAAGAAACAACTTCTGAATTCGATCGTGAAAAATTACAAGAGCGTCTTGCAAAACTTGTAGGTGGCG
TAGCAGTAATTAAAGTAGGTGCAGCAACTGAAACTGAGTTGAAAGAGCGCAAACTTCGCATTGAAGATGCACTTAACTCA
ACTCGTGCAGCAGTAGAAGAAGGTATCGTTGCAGGTGGTGGTACTTCACTTATGAACGTATACACAAAAGTAGCTTCTAT
CGTAGCTGAAGGTGACGAAGCAACAGGTATCAACATCGTACTTCGTGCACTAGAAGAGCCAGTTCGTCAAATCGCAATCA
ACGCTGGTCTAGAAGGATCTGTAGTTGTAGAGCGTCTAAAAGGCGAAAAAGTAGGCGTTGGTTTCAACGCAGCTACTGGC
GAATGGGTTAACATGCTTGAAACTGGTATCGTAGATCCAGCCAAAGTAACTCGCTCTGCACTTCAAAACGCAGCATCTGT
TGCAGCTATGTTCTTAACAACTGAAGCTGTAGTAGCTGACAAGCCAGAACCAAATGCACCAGCAATGCCTGACATGGGCG
GCATGGGCATGGGCGGTATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
AATATGAAGGTACAGACTACTTGATTTTACGTGAAAGTGACATTTTAGCAGTTATCGGTTAATTATATAAATCTTAAAAA
ATCCAAGGGGGTCAATTATT

Downstream 100 bases:

>100_bases
TTCCGTTTGCCCTAAAAAACATCCATTTCTATATAGAAATGGATGTTTTTTTATGTTTTTTAGAAAAGGAAATGAATTTC
TGTAGAATTTTGTCGCTTTC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGK
VVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLVGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM

Sequences:

>Translated_544_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGK
VVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLVGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM
>Mature_543_residues
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTN
DVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIA
EAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQQ
GKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGKV
VVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLVGGVAVIKVGAATETELKERKLRIEDALNST
RAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGE
WVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=51.7110266159696, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=51.7110266159696, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI24307939, Length=372, Percent_Identity=25.2688172043011, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI5453603, Length=567, Percent_Identity=23.4567901234568, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38455427, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=64.1366223908918, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=47.9245283018868, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=45.933014354067, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25147750, Length=560, Percent_Identity=25.1785714285714, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17564182, Length=556, Percent_Identity=24.1007194244604, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=185, Percent_Identity=30.2702702702703, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.0534351145038, Blast_Score=525, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322350, Length=565, Percent_Identity=23.0088495575221, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=537, Percent_Identity=21.7877094972067, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=50.3787878787879, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=50.3787878787879, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=48.5714285714286, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=48.5714285714286, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=48.5714285714286, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=42.7255985267035, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=540, Percent_Identity=36.6666666666667, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI19921262, Length=540, Percent_Identity=36.6666666666667, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI28571140, Length=567, Percent_Identity=24.6913580246914, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI18858175, Length=567, Percent_Identity=24.6913580246914, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24645179, Length=508, Percent_Identity=24.4094488188976, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583944, Length=542, Percent_Identity=23.8007380073801, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17647245, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24652903, Length=130, Percent_Identity=31.5384615384615, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_BACAA (C3PAV1)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864892.1
- ProteinModelPortal:   C3PAV1
- SMR:   C3PAV1
- EnsemblBacteria:   EBBACT00000130425
- GeneID:   7848100
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0309
- GeneTree:   EBGT00050000001186
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57433; Mature: 57302

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLVGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLVGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA