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The map label for this gene is 49183261

Identifier: 49183261

GI number: 49183261

Start: 228946

End: 230118

Strand: Direct

Name: 49183261

Synonym: BAS0228

Alternate gene names: NA

Gene position: 228946-230118 (Clockwise)

Preceding gene: 49183260

Following gene: 49183262

Centisome position: 4.38

GC content: 38.87

Gene sequence:

>1173_bases
ATGTTTTATCGTCACATGGGGGAGCTACCTCATAAACGACATGTACAATTCCGTAAAAAAGATGGATCGCTTTATCGTGA
ACAGGTAATGGGAACAAAAGGTTTTTCTGGTACGCAATCTATTTTGTATCATCATTATATGCCAACGGAAGTAGGGCATG
CAGCATTATCACATTCTTGTCAGTTGCAGTATGAAGAAGATGTTGTTCTTTCTCATCGTCACTTTCGCACGAAAGAAAAT
AAAAAAAGTGGTGATGCGGTAAGTGGCAGAAACTTTATACTTGGAAATGAAGATTTATTAATCGGAGTAGTGACTCCGAC
AGAAAAAATGAATTATTTCTACCGTAATGGTGATGGCGATGAAATGTTGTTTGTCCATTACGGAACAGGAAAAATTGAAA
CAATGTTCGGAACGATTCACTATCGAAAAGGTGATTATGTAACAATCCCAATTGGAACGATTTATCGTGTTATTCCAGAT
GAAGGAGAGACTAAGTTTCTTGTTGTAGAGGCAAATAGTCAAATTACAACACCGCGTCGCTATCGTAATGAATATGGACA
ATTGTTAGAGCATAGCCCGTTTTGTGAGAGAGATATTCGTGGCCCGGAAAAATTAGAGACGTATGATGAAAAAGGTGAGT
TTGTCGTAATGACAAAGTCACGAGGATATATGCATAAACATGTTTTAGGACACCATCCGTTAGATGTAGTTGGATGGGAT
GGTTATTTATATCCCTGGGTCTTTAATGTAGAGGATTTTGAGCCAATCACAGGTCGTATTCATCAGCCACCTCCAGTACA
TCAAACGTTCGAGGGTCACAATTTCGTTATTTGTTCTTTCGTACCACGTTTATATGACTATCATCCAGAATCTATTCCGG
CACCGTATTATCATAGTAACGTGAATAGCGATGAAGTACTGTACTATGTAGAAGGTAACTTTATGAGCCGAAAAGGTGTG
GAGGAAGGGTCTATTACACTTCATCCGAGCGGCATTCCTCACGGTCCACATCCTGGGAAAACAGAGGCGAGTATAGGGAA
AAAAGAAACGCTTGAATTAGCTGTTATGATAGATACATTCCGTCCGCTTCGTATTGTAAAACAAGCACATGAAACAGAAG
ATGAAAAATATATGTATAGCTGGATTGAAGAGGGATCATATACTGTGAAATAA

Upstream 100 bases:

>100_bases
GAAGAGTGGCTGCAAGATGGTGATGTGGTAGAGCTTACGATTACTGGTTTAGGTACATTACGTAATACGGTCAAAAAAGA
AAAGGAAGCAGGTGATGAGC

Downstream 100 bases:

>100_bases
ATAAAAAGAGGCATGCTCAATAACGGAGCATGCCTCTTTTATGGAATCGACATGTATAATAATACCAAAAAAAGTTATAG
AAAGATATATAGAAAGGATG

Product: homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVVLSHRHFRTKEN
KKSGDAVSGRNFILGNEDLLIGVVTPTEKMNYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPD
EGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGWD
GYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRKGV
EEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK

Sequences:

>Translated_390_residues
MFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVVLSHRHFRTKEN
KKSGDAVSGRNFILGNEDLLIGVVTPTEKMNYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPD
EGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGWD
GYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRKGV
EEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK
>Mature_390_residues
MFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVVLSHRHFRTKEN
KKSGDAVSGRNFILGNEDLLIGVVTPTEKMNYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPD
EGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGWD
GYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRKGV
EEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 45144; Mature: 45144

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSC
CCCCHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHEEEEECCCHHHHHHHHCCCE
QLQYEEDVVLSHRHFRTKENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMNYFYRNGDGD
EEEECCCEEECHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECCCCC
EMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVVEANSQITTPRR
EEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCCCHH
YRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGWD
HHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEEECC
GYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSN
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCEECC
VNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTF
CCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
RPLRIVKQAHETEDEKYMYSWIEEGSYTVK
CHHHHHHHHHCCCCHHHHHHHHHCCCEECC
>Mature Secondary Structure
MFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSC
CCCCHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHEEEEECCCHHHHHHHHCCCE
QLQYEEDVVLSHRHFRTKENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMNYFYRNGDGD
EEEECCCEEECHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECCCCC
EMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVVEANSQITTPRR
EEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCCCHH
YRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGWD
HHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEEECC
GYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSN
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCEECC
VNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTF
CCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
RPLRIVKQAHETEDEKYMYSWIEEGSYTVK
CHHHHHHHHHCCCCHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]