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The map label for this gene is serS

Identifier: 49183051

GI number: 49183051

Start: 20339

End: 21613

Strand: Direct

Name: serS

Synonym: BAS0015

Alternate gene names: 49183051

Gene position: 20339-21613 (Clockwise)

Preceding gene: 49183050

Following gene: 49183052

Centisome position: 0.39

GC content: 38.27

Gene sequence:

>1275_bases
ATGCTTGATATTAAATTTTTACGTACAAATTTTGAAGAAGTAAAAGCAAAGTTACAGCATAGAGGCGAAGATTTAACTGA
TTTTGGTCGCTTTGAAGAATTGGATACGAGAAGAAGAGAACTACTTGTTCAAACAGAGGAACTAAAAAGTAAACGTAACG
AAGTATCTCAACAAATCTCTGTATTGAAGCGCGAAAAGAAAGATGCAGAAGCTCTAATTCTAGAAATGCGTGAAGTTGGA
GAAAAAGTAAAAGATCTTGATAATGAACTTCGTACAGTTGAAGAAGATTTAGAAAGATTGATGTTATCTATTCCAAATAT
CCCTCACGAATCTGCTCCAGTTGGTGAAACAGAGGATGATAATGTAGTAGCTCGTACTTGGGGAGAAGTGAAAGAATTTG
CTTTTGAACCAAAACCACATTGGGATCTTGCTACAGATTTAGGAATCTTAGATTTTGAGCGTGCTGGAAAAGTAACAGGA
AGCCGCTTCGTATTCTACAAAGGTGCTGGCGCAAGATTAGAGCGTGCTTTAATTAGCTTTATGCTTGATCTTCATACTGA
TGAGCATGGATATGAAGAAGTATTACCTCCGTACATGGTAAACCGTGCAAGCATGACAGGGACAGGACAACTTCCGAAGT
TTGAAGAAGATGCATTCCGTATTGAAAGTGAAGACTACTTCTTAATTCCAACAGCTGAAGTACCTGTAACAAATATGCAC
CGTGATGAAATCTTAAATAAAGAGCAATTACCTATAAGATATGCTGCATTTAGCTCTTGTTTCCGTTCTGAAGCAGGTTC
AGCTGGCCGTGATACACGTGGTTTAATTCGTCAGCATCAGTTCAATAAAGTAGAGCTTGTAAAGTTCGTAAAACCAGAAG
ATTCTTACGAAGAGTTAGAAAAACTAACAAATGATGCAGAACGCGTGTTACAATTATTAGAGTTGCCATATCGCGTTATG
AGCATGTGCACAGGCGATTTAGGATTTACAGCAGCGAAGAAATACGATATCGAAGTATGGATTCCAAGCTATGGCACATA
TCGTGAAATCTCTTCTTGTAGTAATTTCGAGGCTTTCCAAGCGAGACGTGCAAATATCCGTTTCCGTCGTGAGCCAAACG
GCAAACCAGAACATGTTCATACATTAAATGGATCTGGTCTTGCAATTGGACGTACGGTAGCAGCTATTTTAGAGAACTAC
CAACAAGAAGATGGTACAATTATAATTCCAGAAGTTCTTCGCCCTTATATGGGAGGAAAAACAGTTATTAAGTAA

Upstream 100 bases:

>100_bases
GTAATGCTTTCAACTAGGGTGGCAACGCGGGTTAACTCCCGTCCCTTTATATAGGGACGGGAGTTTTTTGTGTTTTATAA
AATAAAAGGAGGAGTATATA

Downstream 100 bases:

>100_bases
ATTTATAAACATTCATCGGTATGAGTGATTGGTAATTATGAGCGTTGTCAGTACTATAATGTAGGAGGGGAAAAGTAAAA
TTTTCCTTTCCTCATAATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Sequences:

>Translated_424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK
>Mature_424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=333, Percent_Identity=39.6396396396396, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI8923421, Length=396, Percent_Identity=30.8080808080808, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI225579074, Length=334, Percent_Identity=33.2335329341317, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=52.112676056338, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=31.1015118790497, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=355, Percent_Identity=29.2957746478873, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=392, Percent_Identity=35.969387755102, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321799, Length=398, Percent_Identity=32.1608040201005, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24581334, Length=332, Percent_Identity=38.2530120481928, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI17737985, Length=299, Percent_Identity=35.7859531772575, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BACAA (C3P9G2)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002864668.1
- ProteinModelPortal:   C3P9G2
- SMR:   C3P9G2
- EnsemblBacteria:   EBBACT00000125970
- GeneID:   7850194
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_0018
- GeneTree:   EBGT00050000002086
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48745; Mature: 48745

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAEALILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISF
CCHHHHHHHHHHHHCCCCCCCCHHHCCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEEEECCCCCCCCCC
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC
>Mature Secondary Structure
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAEALILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVARTWGEVKEFAFEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISF
CCHHHHHHHHHHHHCCCCCCCCHHHCCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEEEECCCCCCCCCC
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA