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The map label for this gene is pyrH

Identifier: 46447511

GI number: 46447511

Start: 2236999

End: 2237754

Strand: Reverse

Name: pyrH

Synonym: pc1877

Alternate gene names: 46447511

Gene position: 2237754-2236999 (Counterclockwise)

Preceding gene: 46447512

Following gene: 46447510

Centisome position: 92.68

GC content: 37.17

Gene sequence:

>756_bases
ATGAGCACCTTTCCCAAGCGCATTTTACTCAAGTTATCGGGAGAAACGTTGATTGGTAACCAAGGCTTTGGCATCCAGCA
ACAAGCTTGCCTTCAAATTACTAAATCTATTCAACAAATTCAACAATTGGGAATCCAATTAGGAATTGTGATTGGAGGAG
GAAATATTTTCAGAGGAATAAACCTTAAAGCAAATGGAATGCCTCGTGTTCCTGCAGACCATATGGGAATGCTTGCAACG
CTTTTAAATGGGATCGCTCTTCAACAAGCTTTAATAAGTTTAGAAGTCAAAACGTGCGTGATGAGTGCCTTAGACTGTCC
AAAAGTAGCAGAGTCTTATCAATGGAGTAAAGCTTTGCAATATTTAGAAGAGGGGGTGGTTGTCATTTTCGTCGGAGGAA
CAGGTAACCCCTATTTTACAACAGATACAGCTGCAGCTTTAAGAGCAAGTGAAATACAAGCAAATTTACTGCTTAAAGCG
ACTAAGGTAGATGGGATTTATAATCAGGATCCTTTAAAAAATACCCAAGCTGTCAAATATGATCGAATTTCTTATTCTCA
AGTGCTTGCAGAAAAATTACAAGTCATGGATGCTACTGCTATTGCTTTATGTAGAAATCATCAAATTCCTATCTTTGTGT
TTAACATGAAGCGTCTATTTGAAAATAGATTAGACCATGTCTTAACAGATTATAGTCATGGAACTTTAGTTGATGATGGA
GAAATTGGTCATGAAGCTAACAAGCTAGATAGATAA

Upstream 100 bases:

>100_bases
AGTTTTATAAGAAGTTAAACGCAGTATTGATTTACAAATGGAAAGTTTAGCTAGAGCTTTTTAAGGATTTTAAATTATTT
TTACCTTTTCTAAGGATTTT

Downstream 100 bases:

>100_bases
TAGGAGTTAATATGAGCATAGTTGATCAAACTAAAACCAAAATGATAACGGCAATTGAACATTTAAAGAATGATTTGAAA
AATATTCGTACGGGTCGTGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSTFPKRILLKLSGETLIGNQGFGIQQQACLQITKSIQQIQQLGIQLGIVIGGGNIFRGINLKANGMPRVPADHMGMLAT
LLNGIALQQALISLEVKTCVMSALDCPKVAESYQWSKALQYLEEGVVVIFVGGTGNPYFTTDTAAALRASEIQANLLLKA
TKVDGIYNQDPLKNTQAVKYDRISYSQVLAEKLQVMDATAIALCRNHQIPIFVFNMKRLFENRLDHVLTDYSHGTLVDDG
EIGHEANKLDR

Sequences:

>Translated_251_residues
MSTFPKRILLKLSGETLIGNQGFGIQQQACLQITKSIQQIQQLGIQLGIVIGGGNIFRGINLKANGMPRVPADHMGMLAT
LLNGIALQQALISLEVKTCVMSALDCPKVAESYQWSKALQYLEEGVVVIFVGGTGNPYFTTDTAAALRASEIQANLLLKA
TKVDGIYNQDPLKNTQAVKYDRISYSQVLAEKLQVMDATAIALCRNHQIPIFVFNMKRLFENRLDHVLTDYSHGTLVDDG
EIGHEANKLDR
>Mature_250_residues
STFPKRILLKLSGETLIGNQGFGIQQQACLQITKSIQQIQQLGIQLGIVIGGGNIFRGINLKANGMPRVPADHMGMLATL
LNGIALQQALISLEVKTCVMSALDCPKVAESYQWSKALQYLEEGVVVIFVGGTGNPYFTTDTAAALRASEIQANLLLKAT
KVDGIYNQDPLKNTQAVKYDRISYSQVLAEKLQVMDATAIALCRNHQIPIFVFNMKRLFENRLDHVLTDYSHGTLVDDGE
IGHEANKLDR

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=48.7179487179487, Blast_Score=232, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PARUW (Q6M9Z8)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008876.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q6M9Z8
- SMR:   Q6M9Z8
- STRING:   Q6M9Z8
- GeneID:   2781391
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1877
- NMPDR:   fig|264201.1.peg.1877
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q6M9Z8
- ProtClustDB:   CLSK2762521
- BioCyc:   CPRO264201:PC1877-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27560; Mature: 27429

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 73-73 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFPKRILLKLSGETLIGNQGFGIQQQACLQITKSIQQIQQLGIQLGIVIGGGNIFRGI
CCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEE
NLKANGMPRVPADHMGMLATLLNGIALQQALISLEVKTCVMSALDCPKVAESYQWSKALQ
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YLEEGVVVIFVGGTGNPYFTTDTAAALRASEIQANLLLKATKVDGIYNQDPLKNTQAVKY
HHHCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEE
DRISYSQVLAEKLQVMDATAIALCRNHQIPIFVFNMKRLFENRLDHVLTDYSHGTLVDDG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEECCC
EIGHEANKLDR
CCCCCHHCCCC
>Mature Secondary Structure 
STFPKRILLKLSGETLIGNQGFGIQQQACLQITKSIQQIQQLGIQLGIVIGGGNIFRGI
CCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEE
NLKANGMPRVPADHMGMLATLLNGIALQQALISLEVKTCVMSALDCPKVAESYQWSKALQ
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YLEEGVVVIFVGGTGNPYFTTDTAAALRASEIQANLLLKATKVDGIYNQDPLKNTQAVKY
HHHCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEE
DRISYSQVLAEKLQVMDATAIALCRNHQIPIFVFNMKRLFENRLDHVLTDYSHGTLVDDG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEECCC
EIGHEANKLDR
CCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA