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The map label for this gene is dinP

Identifier: 46447454

GI number: 46447454

Start: 2174317

End: 2175369

Strand: Reverse

Name: dinP

Synonym: pc1820

Alternate gene names: 46447454

Gene position: 2175369-2174317 (Counterclockwise)

Preceding gene: 46447455

Following gene: 46447453

Centisome position: 90.1

GC content: 34.85

Gene sequence:

>1053_bases
ATGACACTTCGAAAAATCATTCACATAGATATGGATGCTTTTTATGCTTCTGTTGAAATGCGAGATGATCCTTCATTAGT
TTTAAAGCCAATTGCGGTAGGGGGTGATCCAGATAAACGAGGAGTTATTGCAACAGCTAATTATTTAGCTCGTAAATTTG
GGGTACGTTCTGCTATGCCCTCTTGGAAAGCTAAACAGCTTTGTCCAGATCTAATTATTTTATTTCCTGATTTTGATAAA
TATAAACGAGAAAGTAAAGCTATTCATGAGATTTTTCATCTATTTACAGATTTGATAGAACCTCTTTCTTTAGATGAAGC
TTTTTTAGATGTGACAGATGTAGATGCCTTAAGAGGCAGTGCAACGTGGATCGCGCAAGAGATTCGGCAATTAATTTGGA
AGGAAAGAGGATTAACCGCGTCTGCTGGAGTAGCTCCTAATAAATTTTTAGCTAAAGTGGCAAGTGATTGGCATAAACCA
AATGGTCAGTTTGTGTTAACACCTAAAGAAGTTGATGCTTTTATGGTCCATCTTCCTGTTGAGAAGATTTTTGGAATTGG
CCATGTCATGGCAAAAAAATTACACAGTTTAGGATTAATGAATTGCGGGGATTTACAGACACTTGACATTACAACTTTGC
AAAAACTTTTTGGAAGCCGGGCTTGGAATCTTTATGAGCTATGCCGAGGAATTGATCATCGTTTTGTCATATCAGATCGT
ATTCGAAAGTCATTAAGTGTAGAGTCCACATTTTTGGAAGATTTAAATAATTTGGAGCTTTGTTATCAAGAGATTCCAAA
TTTGATAGAGAGGTTGATGATTCGATATGAGAAAATTTCTAATCAATATTATAAAAAAAAACCTTTTATCAAGATCAAGT
TTGCAGATTTTACAACTACCACGGTCGAAAATACTTTTTTTAAAGCGTTTGATTTAGAAACTTATCAAACGTTAATTCGA
ATAGGATGGGAAAGAAAAAAAGCGCCTGTTCGTCTTTTGGGACTCGGAATGAGTTTAAGTCTTGAAGAAGAGATTCAATT
AACACTTTTTTAA

Upstream 100 bases:

>100_bases
TTTGCTTTCTGCTACCTTGTCTATATGTGCCGTTATCCCTGAATAATAAGTGATAAAATATTCAGATTAAACTTCTTAGC
AATTTATTATTCTTTTATTT

Downstream 100 bases:

>100_bases
TGGCTATTTTAAAGAGTTATCGTATAGGTCATTCCTTTCTTTAATTTAAAAAATTTGCCTTAAAAGCCATCAAAGAGGAT
AAAAAGGGGGAGAGGGAGTA

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTLRKIIHIDMDAFYASVEMRDDPSLVLKPIAVGGDPDKRGVIATANYLARKFGVRSAMPSWKAKQLCPDLIILFPDFDK
YKRESKAIHEIFHLFTDLIEPLSLDEAFLDVTDVDALRGSATWIAQEIRQLIWKERGLTASAGVAPNKFLAKVASDWHKP
NGQFVLTPKEVDAFMVHLPVEKIFGIGHVMAKKLHSLGLMNCGDLQTLDITTLQKLFGSRAWNLYELCRGIDHRFVISDR
IRKSLSVESTFLEDLNNLELCYQEIPNLIERLMIRYEKISNQYYKKKPFIKIKFADFTTTTVENTFFKAFDLETYQTLIR
IGWERKKAPVRLLGLGMSLSLEEEIQLTLF

Sequences:

>Translated_350_residues
MTLRKIIHIDMDAFYASVEMRDDPSLVLKPIAVGGDPDKRGVIATANYLARKFGVRSAMPSWKAKQLCPDLIILFPDFDK
YKRESKAIHEIFHLFTDLIEPLSLDEAFLDVTDVDALRGSATWIAQEIRQLIWKERGLTASAGVAPNKFLAKVASDWHKP
NGQFVLTPKEVDAFMVHLPVEKIFGIGHVMAKKLHSLGLMNCGDLQTLDITTLQKLFGSRAWNLYELCRGIDHRFVISDR
IRKSLSVESTFLEDLNNLELCYQEIPNLIERLMIRYEKISNQYYKKKPFIKIKFADFTTTTVENTFFKAFDLETYQTLIR
IGWERKKAPVRLLGLGMSLSLEEEIQLTLF
>Mature_349_residues
TLRKIIHIDMDAFYASVEMRDDPSLVLKPIAVGGDPDKRGVIATANYLARKFGVRSAMPSWKAKQLCPDLIILFPDFDKY
KRESKAIHEIFHLFTDLIEPLSLDEAFLDVTDVDALRGSATWIAQEIRQLIWKERGLTASAGVAPNKFLAKVASDWHKPN
GQFVLTPKEVDAFMVHLPVEKIFGIGHVMAKKLHSLGLMNCGDLQTLDITTLQKLFGSRAWNLYELCRGIDHRFVISDRI
RKSLSVESTFLEDLNNLELCYQEIPNLIERLMIRYEKISNQYYKKKPFIKIKFADFTTTTVENTFFKAFDLETYQTLIRI
GWERKKAPVRLLGLGMSLSLEEEIQLTLF

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=299, Percent_Identity=33.4448160535117, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI7706681, Length=300, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI154350220, Length=309, Percent_Identity=33.0097087378641, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI7705344, Length=107, Percent_Identity=55.1401869158878, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI5729982, Length=328, Percent_Identity=28.3536585365854, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786425, Length=352, Percent_Identity=50.5681818181818, Blast_Score=320, Evalue=8e-89,
Organism=Escherichia coli, GI1787432, Length=218, Percent_Identity=32.1100917431193, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193205700, Length=343, Percent_Identity=31.7784256559767, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17537959, Length=257, Percent_Identity=28.0155642023346, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193205702, Length=239, Percent_Identity=33.4728033472803, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534089, Length=161, Percent_Identity=34.1614906832298, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324921, Length=213, Percent_Identity=27.6995305164319, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19923006, Length=367, Percent_Identity=29.700272479564, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21355641, Length=283, Percent_Identity=31.8021201413428, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24644984, Length=283, Percent_Identity=31.8021201413428, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24668444, Length=119, Percent_Identity=34.453781512605, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_PARUW (Q6MA55)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008819.1
- HSSP:   Q9UHC5
- ProteinModelPortal:   Q6MA55
- SMR:   Q6MA55
- STRING:   Q6MA55
- GeneID:   2780085
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1820
- NMPDR:   fig|264201.1.peg.1820
- eggNOG:   COG0389
- HOGENOM:   HBG734504
- OMA:   SIGLERT
- PhylomeDB:   Q6MA55
- ProtClustDB:   PRK02406
- BioCyc:   CPRO264201:PC1820-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 40194; Mature: 40063

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRKIIHIDMDAFYASVEMRDDPSLVLKPIAVGGDPDKRGVIATANYLARKFGVRSAMP
CCCHHEEEEEHHHHEEEEEECCCCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCC
SWKAKQLCPDLIILFPDFDKYKRESKAIHEIFHLFTDLIEPLSLDEAFLDVTDVDALRGS
CCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
ATWIAQEIRQLIWKERGLTASAGVAPNKFLAKVASDWHKPNGQFVLTPKEVDAFMVHLPV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCEEEEEECH
EKIFGIGHVMAKKLHSLGLMNCGDLQTLDITTLQKLFGSRAWNLYELCRGIDHRFVISDR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHCCCCCEEEEHHH
IRKSLSVESTFLEDLNNLELCYQEIPNLIERLMIRYEKISNQYYKKKPFIKIKFADFTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEH
TVENTFFKAFDLETYQTLIRIGWERKKAPVRLLGLGMSLSLEEEIQLTLF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TLRKIIHIDMDAFYASVEMRDDPSLVLKPIAVGGDPDKRGVIATANYLARKFGVRSAMP
CCHHEEEEEHHHHEEEEEECCCCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCC
SWKAKQLCPDLIILFPDFDKYKRESKAIHEIFHLFTDLIEPLSLDEAFLDVTDVDALRGS
CCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
ATWIAQEIRQLIWKERGLTASAGVAPNKFLAKVASDWHKPNGQFVLTPKEVDAFMVHLPV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCEEEEEECH
EKIFGIGHVMAKKLHSLGLMNCGDLQTLDITTLQKLFGSRAWNLYELCRGIDHRFVISDR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHCCCCCEEEEHHH
IRKSLSVESTFLEDLNNLELCYQEIPNLIERLMIRYEKISNQYYKKKPFIKIKFADFTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEH
TVENTFFKAFDLETYQTLIRIGWERKKAPVRLLGLGMSLSLEEEIQLTLF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA