Click here to switch to the map view.

The map label for this gene is metK [H]

Identifier: 46447451

GI number: 46447451

Start: 2173103

End: 2173363

Strand: Reverse

Name: metK [H]

Synonym: pc1817

Alternate gene names: 46447451

Gene position: 2173363-2173103 (Counterclockwise)

Preceding gene: 46447452

Following gene: 46447450

Centisome position: 90.01

GC content: 38.31

Gene sequence:

>261_bases
TTGTTATGCTGCGCGTTATATAGAGTAAAATTATTGTGGCTGCTAAATTGGCTCGACGTTGTGAAGTGCAGTTATCCTAT
GCCATTGAAATTCTTTACCCTATCTCAAAAAGTAGATACTTTTGGTACGGGAACTGTCAGTGAAGCAGAGTTGAGTCGCA
TTATTCCTCTAATTTTCGACTTGACTACAAAAGGAGTTATTCAAATGCTTAATTTGAAGCGCCCCGTTTATCGTCAAACA
AGCTTACGAAGGTCATTTTGA

Upstream 100 bases:

>100_bases
TAACAGGCCGAAAAATTGTTGTAGATACTTATAAAAGAAGGGGAAAGTATGGTGATGGCGCATTTTCGGGAAAAGTTTTC
TCTAAAGTCGGTCGTTCCGC

Downstream 100 bases:

>100_bases
TCGTAAAGGATCTAACTTTACCTGGGAAAATAGATCGTGTTGCTTCCTTATTAAACAAAATTAATTAAAATAATTAATTT
TATTTTTAAATTTAAATGTA

Product: hypothetical protein

Products: NA

Alternate protein names: AdoMet synthase; MAT; Methionine adenosyltransferase [H]

Number of amino acids: Translated: 86; Mature: 86

Protein sequence:

>86_residues
MLCCALYRVKLLWLLNWLDVVKCSYPMPLKFFTLSQKVDTFGTGTVSEAELSRIIPLIFDLTTKGVIQMLNLKRPVYRQT
SLRRSF

Sequences:

>Translated_86_residues
MLCCALYRVKLLWLLNWLDVVKCSYPMPLKFFTLSQKVDTFGTGTVSEAELSRIIPLIFDLTTKGVIQMLNLKRPVYRQT
SLRRSF
>Mature_86_residues
MLCCALYRVKLLWLLNWLDVVKCSYPMPLKFFTLSQKVDTFGTGTVSEAELSRIIPLIFDLTTKGVIQMLNLKRPVYRQT
SLRRSF

Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the e

COG id: COG0192

COG function: function code H; S-adenosylmethionine synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AdoMet synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: 7,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022631
- InterPro:   IPR022630
- InterPro:   IPR022629
- InterPro:   IPR022628
- InterPro:   IPR002133
- InterPro:   IPR022636 [H]

Pfam domain/function: PF02773 S-AdoMet_synt_C; PF02772 S-AdoMet_synt_M; PF00438 S-AdoMet_synt_N [H]

EC number: =2.5.1.6 [H]

Molecular weight: Translated: 10017; Mature: 10017

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCCALYRVKLLWLLNWLDVVKCSYPMPLKFFTLSQKVDTFGTGTVSEAELSRIIPLIFD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCHHHHHHHHHHHHH
LTTKGVIQMLNLKRPVYRQTSLRRSF
HHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MLCCALYRVKLLWLLNWLDVVKCSYPMPLKFFTLSQKVDTFGTGTVSEAELSRIIPLIFD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCHHHHHHHHHHHHH
LTTKGVIQMLNLKRPVYRQTSLRRSF
HHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA