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The map label for this gene is fabH [H]

Identifier: 46447354

GI number: 46447354

Start: 2059443

End: 2060441

Strand: Reverse

Name: fabH [H]

Synonym: pc1720

Alternate gene names: 46447354

Gene position: 2060441-2059443 (Counterclockwise)

Preceding gene: 46447355

Following gene: 46447353

Centisome position: 85.34

GC content: 39.44

Gene sequence:

>999_bases
ATGGCAAATCAAATAATTGCTCGGATAACAGGCGTAGGATCTTATTTACCTGAACGCGTGCTTTCTAATCAAGATTTAGA
GAAAATGGTCGAGACTTCAGATGATTGGATCGTATCTAGAACGGGAATACGTGAAAGACGCTTAGCAGATGCGAAAGAAT
TTCCTTCCGATATGGGAACTTACGCTGCTCAAAAAGCTCTTAAAACTGCCAATTTGAAAGCTGAGCAAATTGACATGATT
TTAGTTGCCACAATGAGTCCTGATTATATTTCACCCAGTACAGCTAATCTAATTCAAGCAAATCTAGGAGCAAGTAAAGC
AGCCGCTATGGATATTCAGGCAGCTTGTACAGGATTTTTATATGGTTTGTCAGTAGCAAAAGCTTATATTGAATCTAATA
TGTATCGGCATGTTCTTGTTATTGCAACAGAAAAAATGTCTGCCTTTATTGATTATAAGGATCGGACGACATGTGTTTTG
TTCGGTGATGGAGCAGCGGCGGCTGTTGTTAAAGGAGAAGGGGAAGGGTTGAAGATTGATTCCTTGTGTTTGGGTGCGGA
TGGAGAATTAGCTAATTTAGTTTTAATTCCCGGCGGTGGATCGAGAAAACCCGCCTCAATAGAAACGGTTTCGGAAGGGT
TACATTACTTTAAAATGTCAGGTAATGAGGTTTTTAAACATGCTGTTAGGCGCATGAGTGCAGCGGCACGCGAATGTTTA
GTTCGAGCTGAGCTCCAAGAATCTGATGTGAGTTGGCTTATTCCTCATCAAGCAAATAAAAGGATTATTGATGCCATAGC
TAAAAATTTTAATTTCCCCGATGAAAAAGTTTATCAAACTGTTCACAAATATGGAAATACTTCTGCTTCAAGCATCGCAA
TTGCTTTGGATGAATTAATCAAAGAACATAGCTTTGAGAATGGTGAGCATTTTCTCTTAACCGCTTTCGGTGGAGGATTA
ACTTGGGGTGCTTCAATTTTGACCAAAACAACAAGGTAA

Upstream 100 bases:

>100_bases
CCTCGTTAATTGGATTGAAAAATTTTAAATTGGTGCGAGCTAACTTTTTTCTTTGATCATTCCAATTTCAGATAATTTAA
AGAGAGAAGGAATAGTATTC

Downstream 100 bases:

>100_bases
AAATGGATAAAAAAATTTATAAACGCATTTCCTTTCTTTTTCCTGGTCAAGGGGCCCAATATCCAGGAATGGCTAAAGAT
TTTGTGAATCAATTTTCTCT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MANQIIARITGVGSYLPERVLSNQDLEKMVETSDDWIVSRTGIRERRLADAKEFPSDMGTYAAQKALKTANLKAEQIDMI
LVATMSPDYISPSTANLIQANLGASKAAAMDIQAACTGFLYGLSVAKAYIESNMYRHVLVIATEKMSAFIDYKDRTTCVL
FGDGAAAAVVKGEGEGLKIDSLCLGADGELANLVLIPGGGSRKPASIETVSEGLHYFKMSGNEVFKHAVRRMSAAARECL
VRAELQESDVSWLIPHQANKRIIDAIAKNFNFPDEKVYQTVHKYGNTSASSIAIALDELIKEHSFENGEHFLLTAFGGGL
TWGASILTKTTR

Sequences:

>Translated_332_residues
MANQIIARITGVGSYLPERVLSNQDLEKMVETSDDWIVSRTGIRERRLADAKEFPSDMGTYAAQKALKTANLKAEQIDMI
LVATMSPDYISPSTANLIQANLGASKAAAMDIQAACTGFLYGLSVAKAYIESNMYRHVLVIATEKMSAFIDYKDRTTCVL
FGDGAAAAVVKGEGEGLKIDSLCLGADGELANLVLIPGGGSRKPASIETVSEGLHYFKMSGNEVFKHAVRRMSAAARECL
VRAELQESDVSWLIPHQANKRIIDAIAKNFNFPDEKVYQTVHKYGNTSASSIAIALDELIKEHSFENGEHFLLTAFGGGL
TWGASILTKTTR
>Mature_331_residues
ANQIIARITGVGSYLPERVLSNQDLEKMVETSDDWIVSRTGIRERRLADAKEFPSDMGTYAAQKALKTANLKAEQIDMIL
VATMSPDYISPSTANLIQANLGASKAAAMDIQAACTGFLYGLSVAKAYIESNMYRHVLVIATEKMSAFIDYKDRTTCVLF
GDGAAAAVVKGEGEGLKIDSLCLGADGELANLVLIPGGGSRKPASIETVSEGLHYFKMSGNEVFKHAVRRMSAAARECLV
RAELQESDVSWLIPHQANKRIIDAIAKNFNFPDEKVYQTVHKYGNTSASSIAIALDELIKEHSFENGEHFLLTAFGGGLT
WGASILTKTTR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=320, Percent_Identity=43.75, Blast_Score=261, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 36020; Mature: 35888

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQIIARITGVGSYLPERVLSNQDLEKMVETSDDWIVSRTGIRERRLADAKEFPSDMGT
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHHH
YAAQKALKTANLKAEQIDMILVATMSPDYISPSTANLIQANLGASKAAAMDIQAACTGFL
HHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
YGLSVAKAYIESNMYRHVLVIATEKMSAFIDYKDRTTCVLFGDGAAAAVVKGEGEGLKID
HHHHHHHHHHHCCCCEEEEEEEECHHHHEEECCCCEEEEEEECCCEEEEEECCCCCEEEE
SLCLGADGELANLVLIPGGGSRKPASIETVSEGLHYFKMSGNEVFKHAVRRMSAAARECL
EEEECCCCCEEEEEEECCCCCCCCCHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHH
VRAELQESDVSWLIPHQANKRIIDAIAKNFNFPDEKVYQTVHKYGNTSASSIAIALDELI
HHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEHSFENGEHFLLTAFGGGLTWGASILTKTTR
HHCCCCCCCEEEEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
ANQIIARITGVGSYLPERVLSNQDLEKMVETSDDWIVSRTGIRERRLADAKEFPSDMGT
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHHH
YAAQKALKTANLKAEQIDMILVATMSPDYISPSTANLIQANLGASKAAAMDIQAACTGFL
HHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
YGLSVAKAYIESNMYRHVLVIATEKMSAFIDYKDRTTCVLFGDGAAAAVVKGEGEGLKID
HHHHHHHHHHHCCCCEEEEEEEECHHHHEEECCCCEEEEEEECCCEEEEEECCCCCEEEE
SLCLGADGELANLVLIPGGGSRKPASIETVSEGLHYFKMSGNEVFKHAVRRMSAAARECL
EEEECCCCCEEEEEEECCCCCCCCCHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHH
VRAELQESDVSWLIPHQANKRIIDAIAKNFNFPDEKVYQTVHKYGNTSASSIAIALDELI
HHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEHSFENGEHFLLTAFGGGLTWGASILTKTTR
HHCCCCCCCEEEEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]