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The map label for this gene is fabD [H]

Identifier: 46447353

GI number: 46447353

Start: 2058490

End: 2059479

Strand: Reverse

Name: fabD [H]

Synonym: pc1719

Alternate gene names: 46447353

Gene position: 2059479-2058490 (Counterclockwise)

Preceding gene: 46447354

Following gene: 46447352

Centisome position: 85.3

GC content: 37.78

Gene sequence:

>990_bases
TTGGGGTGCTTCAATTTTGACCAAAACAACAAGGTAAAAATGGATAAAAAAATTTATAAACGCATTTCCTTTCTTTTTCC
TGGTCAAGGGGCCCAATATCCAGGAATGGCTAAAGATTTTGTGAATCAATTTTCTCTGGCTCAACTTACATTTGAAGAGG
CCGATGATATTTTAAAGCGTTCTCTTTCAAATATTGTATTTAATGGTTCTGAAGAGGAGTTGACTTTAACAAAAAATAGT
CAGCTTGGAATTTATGTCTCTAGTATAGCCATTTTGCGAGTAGTTTCCGAATTATACAATTTAAAGCCATTTGTTTGTTC
AGGTCTTAGTTTAGGGGAATATACAGCATTAACTGCGAGTGAAATGCTCCCATATCAAGAGACTTTGCCTTTAGTTCGAT
ACCGTAGTGAATATATGCATGAGGCTTGTGAAGAAACTAAAGGATCAATGATTGTTGTCATAGGGCTTGAAAACTCTGTT
GTTGAAGAGATGGTGAACAAGCTGAATTTAACAAATGATTTATGGATTGCTAATTTTAACTGTCCCGGTCAGGTTGTTCT
TTCTGGAACCTCTTTGGGCATTGAAGCTGGAGTTGCAGCGGCCAAGGAGCATGGAGCAAAAAGAGTTCTTCCCTTACGAG
TGGCAGGTGCTTTTCATAGTGGATTAATGCAAGTAGCGGAAAATCGATTGAATCCATTTATTTCGTCAACTCCTTTCCAA
AAAGGGTCTTCTCAACTTGTGATGAACGTGTCTGGGGATTTCGTCGATGATTTAGAACTTGTCCGAACTCATTTAAGCAA
ACAAATCACACATTCTGTTCGATGGGAGCAGGGAATTCGCGCAATCGAAAGTCATGATGTGGATTTATTTATTGAATTTG
GTCCAGGAAAAACACTCAATGGGTTGAATAAGCGAATTGGGGTGAAAGCACCAACATTGTCTATTGAAAAAGTAGAGGAT
TTAGCTCTTTTAGATCATATTATCCAATAG

Upstream 100 bases:

>100_bases
CTGCTTCAAGCATCGCAATTGCTTTGGATGAATTAATCAAAGAACATAGCTTTGAGAATGGTGAGCATTTTCTCTTAACC
GCTTTCGGTGGAGGATTAAC

Downstream 100 bases:

>100_bases
AAAAGAGATGAAACCGACTAGAACAAGTCAATTGCTAATGCTGTACTAAGTTTATATAAAGGAATGACGATGAATCAGTT
GTTGTTAAATCAAGTAGCTA

Product: putative malonyl CoA-acyl carrier protein transacylase, fabD

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MGCFNFDQNNKVKMDKKIYKRISFLFPGQGAQYPGMAKDFVNQFSLAQLTFEEADDILKRSLSNIVFNGSEEELTLTKNS
QLGIYVSSIAILRVVSELYNLKPFVCSGLSLGEYTALTASEMLPYQETLPLVRYRSEYMHEACEETKGSMIVVIGLENSV
VEEMVNKLNLTNDLWIANFNCPGQVVLSGTSLGIEAGVAAAKEHGAKRVLPLRVAGAFHSGLMQVAENRLNPFISSTPFQ
KGSSQLVMNVSGDFVDDLELVRTHLSKQITHSVRWEQGIRAIESHDVDLFIEFGPGKTLNGLNKRIGVKAPTLSIEKVED
LALLDHIIQ

Sequences:

>Translated_329_residues
MGCFNFDQNNKVKMDKKIYKRISFLFPGQGAQYPGMAKDFVNQFSLAQLTFEEADDILKRSLSNIVFNGSEEELTLTKNS
QLGIYVSSIAILRVVSELYNLKPFVCSGLSLGEYTALTASEMLPYQETLPLVRYRSEYMHEACEETKGSMIVVIGLENSV
VEEMVNKLNLTNDLWIANFNCPGQVVLSGTSLGIEAGVAAAKEHGAKRVLPLRVAGAFHSGLMQVAENRLNPFISSTPFQ
KGSSQLVMNVSGDFVDDLELVRTHLSKQITHSVRWEQGIRAIESHDVDLFIEFGPGKTLNGLNKRIGVKAPTLSIEKVED
LALLDHIIQ
>Mature_328_residues
GCFNFDQNNKVKMDKKIYKRISFLFPGQGAQYPGMAKDFVNQFSLAQLTFEEADDILKRSLSNIVFNGSEEELTLTKNSQ
LGIYVSSIAILRVVSELYNLKPFVCSGLSLGEYTALTASEMLPYQETLPLVRYRSEYMHEACEETKGSMIVVIGLENSVV
EEMVNKLNLTNDLWIANFNCPGQVVLSGTSLGIEAGVAAAKEHGAKRVLPLRVAGAFHSGLMQVAENRLNPFISSTPFQK
GSSQLVMNVSGDFVDDLELVRTHLSKQITHSVRWEQGIRAIESHDVDLFIEFGPGKTLNGLNKRIGVKAPTLSIEKVEDL
ALLDHIIQ

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=322, Percent_Identity=27.639751552795, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1787334, Length=286, Percent_Identity=32.8671328671329, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71984332, Length=300, Percent_Identity=24.6666666666667, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=291, Percent_Identity=24.3986254295533, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24665753, Length=320, Percent_Identity=31.875, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 36465; Mature: 36334

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCFNFDQNNKVKMDKKIYKRISFLFPGQGAQYPGMAKDFVNQFSLAQLTFEEADDILKR
CCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLSNIVFNGSEEELTLTKNSQLGIYVSSIAILRVVSELYNLKPFVCSGLSLGEYTALTAS
HHHHHEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHH
EMLPYQETLPLVRYRSEYMHEACEETKGSMIVVIGLENSVVEEMVNKLNLTNDLWIANFN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECC
CPGQVVLSGTSLGIEAGVAAAKEHGAKRVLPLRVAGAFHSGLMQVAENRLNPFISSTPFQ
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC
KGSSQLVMNVSGDFVDDLELVRTHLSKQITHSVRWEQGIRAIESHDVDLFIEFGPGKTLN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GLNKRIGVKAPTLSIEKVEDLALLDHIIQ
CHHHHCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GCFNFDQNNKVKMDKKIYKRISFLFPGQGAQYPGMAKDFVNQFSLAQLTFEEADDILKR
CCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLSNIVFNGSEEELTLTKNSQLGIYVSSIAILRVVSELYNLKPFVCSGLSLGEYTALTAS
HHHHHEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHH
EMLPYQETLPLVRYRSEYMHEACEETKGSMIVVIGLENSVVEEMVNKLNLTNDLWIANFN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECC
CPGQVVLSGTSLGIEAGVAAAKEHGAKRVLPLRVAGAFHSGLMQVAENRLNPFISSTPFQ
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC
KGSSQLVMNVSGDFVDDLELVRTHLSKQITHSVRWEQGIRAIESHDVDLFIEFGPGKTLN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GLNKRIGVKAPTLSIEKVEDLALLDHIIQ
CHHHHCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]