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The map label for this gene is atpB

Identifier: 46447308

GI number: 46447308

Start: 2011342

End: 2012157

Strand: Reverse

Name: atpB

Synonym: pc1674

Alternate gene names: 46447308

Gene position: 2012157-2011342 (Counterclockwise)

Preceding gene: 46447309

Following gene: 46447307

Centisome position: 83.34

GC content: 35.05

Gene sequence:

>816_bases
ATGATTATGGGGCAATATTTATTCTGGCTTGCTAATGCTCACGAACCAATTGAAAATCGAATACCAGAATTACCTAATTT
TATTTCCGTGCTCTATCATCGTTTTCAACATACAACTTGGGCGCAGTTTTTACATCGTTGGGAAAATATCATTTTTGCCA
TTCTCGTTGCCAGTCTCATTTCTTTAGTGGCCTATTTAGGTGCGCGAAAAAAAGAAATTATCCCATCGAAATTTCAGAAT
CTATTAGAAATCGCAGTGGAGAAATTTAGTCATTTAATATTAGAAGTGTTAGGTCCTGAAGGAAAAGCTTACATTCCGTT
TTTAGGAACGCTATTTATCTACATTTTTACTATGAATATATTTGGAATGGTTCCTTTAATGAAAGCGCCTTCGTCTAGTT
TGAATATTACCGCAGCTTTGGCGATTTGTGTATTCTGTTTAGTTCAATTTTTGAATATACGAAATATGGGAATTTTTGGT
TTTTTATATCATTTGGCTGGCTCGCCCAAAAGTATGCTAGAGTGGCTCCTTGCTCCTTTAATGTTTTCTTTGGAAATCAT
TTCACAGCTTTCTCGCCCCCTTACTCTTGCTCTACGTTTATTTGGAAACGTGCTTGGAGAAGATATCTTAATAGGAACAT
TTGCTTTAATGGGAGTTGTTATGATTTCTTCTGTTGAGACATTCGTAGGCATTCCTTTGCAACTTCCTTTTATGTTTCTG
GGCTTACTTACAAGCTTTATGCAAGCTTTAGTCTTTACTTTATTAAGTACGGTCTATATTTTATTATCTATGCACAAAGA
AGGTGAAAAAAACTGA

Upstream 100 bases:

>100_bases
GTTTGATGAGTGGGTTTTCGCTTCTCTTTATTGCAATTTTTATATTGGGAATTGCTAAAATAATTTTTGAAAAAGTAAAA
GAAAAAGTAGGATCGTCAGC

Downstream 100 bases:

>100_bases
TTTTTTTGCTATTAATTGGATAGTTAAAGTTCGTGATAGCAAAAAAGTAAATACCCTTCTTTTTATGCATATATTTAATC
GTTGCTAAACTCATGCATTT

Product: putative H+-transporting two-sector ATPase (chain a, atpB)

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MIMGQYLFWLANAHEPIENRIPELPNFISVLYHRFQHTTWAQFLHRWENIIFAILVASLISLVAYLGARKKEIIPSKFQN
LLEIAVEKFSHLILEVLGPEGKAYIPFLGTLFIYIFTMNIFGMVPLMKAPSSSLNITAALAICVFCLVQFLNIRNMGIFG
FLYHLAGSPKSMLEWLLAPLMFSLEIISQLSRPLTLALRLFGNVLGEDILIGTFALMGVVMISSVETFVGIPLQLPFMFL
GLLTSFMQALVFTLLSTVYILLSMHKEGEKN

Sequences:

>Translated_271_residues
MIMGQYLFWLANAHEPIENRIPELPNFISVLYHRFQHTTWAQFLHRWENIIFAILVASLISLVAYLGARKKEIIPSKFQN
LLEIAVEKFSHLILEVLGPEGKAYIPFLGTLFIYIFTMNIFGMVPLMKAPSSSLNITAALAICVFCLVQFLNIRNMGIFG
FLYHLAGSPKSMLEWLLAPLMFSLEIISQLSRPLTLALRLFGNVLGEDILIGTFALMGVVMISSVETFVGIPLQLPFMFL
GLLTSFMQALVFTLLSTVYILLSMHKEGEKN
>Mature_271_residues
MIMGQYLFWLANAHEPIENRIPELPNFISVLYHRFQHTTWAQFLHRWENIIFAILVASLISLVAYLGARKKEIIPSKFQN
LLEIAVEKFSHLILEVLGPEGKAYIPFLGTLFIYIFTMNIFGMVPLMKAPSSSLNITAALAICVFCLVQFLNIRNMGIFG
FLYHLAGSPKSMLEWLLAPLMFSLEIISQLSRPLTLALRLFGNVLGEDILIGTFALMGVVMISSVETFVGIPLQLPFMFL
GLLTSFMQALVFTLLSTVYILLSMHKEGEKN

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=218, Percent_Identity=26.605504587156, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_PARUW (Q6MAK1)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008673.1
- ProteinModelPortal:   Q6MAK1
- SMR:   Q6MAK1
- STRING:   Q6MAK1
- GeneID:   2779777
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1674
- NMPDR:   fig|264201.1.peg.1674
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   YIFTILT
- PhylomeDB:   Q6MAK1
- ProtClustDB:   CLSK2762450
- BioCyc:   CPRO264201:PC1674-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30623; Mature: 30623

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe71fc74)-; HASH(0xf45eb54)-; HASH(0xf44fe60)-; HASH(0xecfae54)-; HASH(0xf458768)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMGQYLFWLANAHEPIENRIPELPNFISVLYHRFQHTTWAQFLHRWENIIFAILVASLI
CCCHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVAYLGARKKEIIPSKFQNLLEIAVEKFSHLILEVLGPEGKAYIPFLGTLFIYIFTMNI
HHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FGMVPLMKAPSSSLNITAALAICVFCLVQFLNIRNMGIFGFLYHLAGSPKSMLEWLLAPL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
MFSLEIISQLSRPLTLALRLFGNVLGEDILIGTFALMGVVMISSVETFVGIPLQLPFMFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLLTSFMQALVFTLLSTVYILLSMHKEGEKN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MIMGQYLFWLANAHEPIENRIPELPNFISVLYHRFQHTTWAQFLHRWENIIFAILVASLI
CCCHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVAYLGARKKEIIPSKFQNLLEIAVEKFSHLILEVLGPEGKAYIPFLGTLFIYIFTMNI
HHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FGMVPLMKAPSSSLNITAALAICVFCLVQFLNIRNMGIFGFLYHLAGSPKSMLEWLLAPL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
MFSLEIISQLSRPLTLALRLFGNVLGEDILIGTFALMGVVMISSVETFVGIPLQLPFMFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLLTSFMQALVFTLLSTVYILLSMHKEGEKN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA