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The map label for this gene is atpA

Identifier: 46447304

GI number: 46447304

Start: 2008386

End: 2009912

Strand: Reverse

Name: atpA

Synonym: pc1670

Alternate gene names: 46447304

Gene position: 2009912-2008386 (Counterclockwise)

Preceding gene: 46447305

Following gene: 46447303

Centisome position: 83.24

GC content: 37.79

Gene sequence:

>1527_bases
ATGCGTTTAAATCCTGAAGAAGTATCTTGGGTCATTCAACAAGAAATTGAAAAATATCATGAAGATCTCTCCTTAAAATT
TGAATCTGCTGGACGTGTTTTGTATGTAGGAGATGGAATTGCGCGCGTCTGGGGTCTTGATGATGTGATGATGTCAGAAC
TTGTTGAATTTCCTGATGGAACATTAGGAATTGTTTTGAACCTTGAAATCGATAATGTGGGAGTCATCATTTTAGGTTCC
GATCGAAATATTCGTGAACAAGACATCGTCAAAAGAACAGGAAAAATAGCTTCAGTTCCTGTCGGTGAGGGAATGCTAGG
GCGTGTCATTAATGCTTTGGGACAACCAATTGACGGGAAAGGAGCAATTGAAACAAAAGAATTTAGAGCAATCGAAAGTT
CAGCGCCAGGAGTTGTGCAAAGAAAACCTGTGAATGAACCCGTTCAAACAGGAATTAAGGCCATTGATTCTATGATCCCT
ATTGGACGCGGCCAAAGAGAATTAATCATTGGAGATAGACAAACAGGAAAAACGACTGTTATTCTTGATACAATCATTAA
TCAAAAAAATACGGGAGTTTGTTGTATTTATGTAGCGATTGGGCAAAAATCTTCTACAATTGCTCAAGTTGTCAAAATCT
TAGAAGAACATGATGCAATGAAATATACGATAATTGTAGCTGCCACAGCTTCTGATCCCGCAGCGTTACAGTACGTCGCT
CCCTATTCAGCAACGGCATTAGGTGAGCATTTCATGTACAATGGTAAGCATGTGATCTGCTTTTATGATGACCTTTCTAA
ACATGCACAAGCTTATCGAGAAATAGCTCTTCTTTTAAGAAGACCTCCTGGCCGTGAAGCCTATCCGGGAGATATTTTTT
ATTTACATTCTCGTTTACTTGAAAGATCCGCTAAATTAAGCACTGAATTAGGTGGGGGATCTTTGACAGCGGTACCTGTC
ATTGAAACTCAAGCGAATGACGTGACGACCTATATCCCTACAAACGTTATTTCTATTACAGACGGCCAAATTTATTTAGA
GTCTGATCTTTTTTACGCAGGTGTGCGTCCAGCTATTAATGTGGGAATTTCAGCTTCTAGAGTTGGTGGAAAGGCTCAAT
CGAAAGCCATGAAAAAAGTTGCAGCAAGTCTACGTTTAGATTTAGCTCAATATCGTGAGTTAGCTGCATTTGCTCAATTT
GGTTCTGAAATGGACAAAACAACGCAAGCTCAGCTTGTCCGTGGTGAAAGAATGATAGAAGTTTTAAAGCAAGACAAATT
CAAACCTATTTCATTATCCAAACAAGTGATGATTATTTTTACAGGAACGAAGGGATTCTTGGATGATCTTCCTCTTCCTT
TTATCAAAAATTTTGAAAATGAATTTTATCTATTCATGGATGAAAATCATCCTCATATTTCTAATTCGATTGAACAAAGC
CTTGATTTAGATCAAAAAACGATGGAGCAATTAAACGAAGCTGTGACGAAATTTAAATCTGATTTTAAGTTACGCTATCA
AATATAG

Upstream 100 bases:

>100_bases
TGATTCTGATCATGGATCATCAAATTTTTGATAACAGTGTGAAGAAAAGACTTGCAAAACTAAAAGTTAGCTTATTAACG
GCTAAGGTCTAGGAGAGAGA

Downstream 100 bases:

>100_bases
ATGGGGAATAATAAAAGATGGCTAGTTTAAGAGAAATTCGTAAGCGTTTACAGTCCATTCAAAACATTCAGCAGCTGACC
AAAGCAATGGAAATGGTGGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRLNPEEVSWVIQQEIEKYHEDLSLKFESAGRVLYVGDGIARVWGLDDVMMSELVEFPDGTLGIVLNLEIDNVGVIILGS
DRNIREQDIVKRTGKIASVPVGEGMLGRVINALGQPIDGKGAIETKEFRAIESSAPGVVQRKPVNEPVQTGIKAIDSMIP
IGRGQRELIIGDRQTGKTTVILDTIINQKNTGVCCIYVAIGQKSSTIAQVVKILEEHDAMKYTIIVAATASDPAALQYVA
PYSATALGEHFMYNGKHVICFYDDLSKHAQAYREIALLLRRPPGREAYPGDIFYLHSRLLERSAKLSTELGGGSLTAVPV
IETQANDVTTYIPTNVISITDGQIYLESDLFYAGVRPAINVGISASRVGGKAQSKAMKKVAASLRLDLAQYRELAAFAQF
GSEMDKTTQAQLVRGERMIEVLKQDKFKPISLSKQVMIIFTGTKGFLDDLPLPFIKNFENEFYLFMDENHPHISNSIEQS
LDLDQKTMEQLNEAVTKFKSDFKLRYQI

Sequences:

>Translated_508_residues
MRLNPEEVSWVIQQEIEKYHEDLSLKFESAGRVLYVGDGIARVWGLDDVMMSELVEFPDGTLGIVLNLEIDNVGVIILGS
DRNIREQDIVKRTGKIASVPVGEGMLGRVINALGQPIDGKGAIETKEFRAIESSAPGVVQRKPVNEPVQTGIKAIDSMIP
IGRGQRELIIGDRQTGKTTVILDTIINQKNTGVCCIYVAIGQKSSTIAQVVKILEEHDAMKYTIIVAATASDPAALQYVA
PYSATALGEHFMYNGKHVICFYDDLSKHAQAYREIALLLRRPPGREAYPGDIFYLHSRLLERSAKLSTELGGGSLTAVPV
IETQANDVTTYIPTNVISITDGQIYLESDLFYAGVRPAINVGISASRVGGKAQSKAMKKVAASLRLDLAQYRELAAFAQF
GSEMDKTTQAQLVRGERMIEVLKQDKFKPISLSKQVMIIFTGTKGFLDDLPLPFIKNFENEFYLFMDENHPHISNSIEQS
LDLDQKTMEQLNEAVTKFKSDFKLRYQI
>Mature_508_residues
MRLNPEEVSWVIQQEIEKYHEDLSLKFESAGRVLYVGDGIARVWGLDDVMMSELVEFPDGTLGIVLNLEIDNVGVIILGS
DRNIREQDIVKRTGKIASVPVGEGMLGRVINALGQPIDGKGAIETKEFRAIESSAPGVVQRKPVNEPVQTGIKAIDSMIP
IGRGQRELIIGDRQTGKTTVILDTIINQKNTGVCCIYVAIGQKSSTIAQVVKILEEHDAMKYTIIVAATASDPAALQYVA
PYSATALGEHFMYNGKHVICFYDDLSKHAQAYREIALLLRRPPGREAYPGDIFYLHSRLLERSAKLSTELGGGSLTAVPV
IETQANDVTTYIPTNVISITDGQIYLESDLFYAGVRPAINVGISASRVGGKAQSKAMKKVAASLRLDLAQYRELAAFAQF
GSEMDKTTQAQLVRGERMIEVLKQDKFKPISLSKQVMIIFTGTKGFLDDLPLPFIKNFENEFYLFMDENHPHISNSIEQS
LDLDQKTMEQLNEAVTKFKSDFKLRYQI

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=58.2178217821782, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=58.2178217821782, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI19913426, Length=350, Percent_Identity=29.4285714285714, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI19913428, Length=301, Percent_Identity=30.2325581395349, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI32189394, Length=298, Percent_Identity=26.510067114094, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913424, Length=246, Percent_Identity=28.4552845528455, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790172, Length=511, Percent_Identity=51.46771037182, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1788251, Length=269, Percent_Identity=29.7397769516729, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=25.8215962441315, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71988063, Length=505, Percent_Identity=56.8316831683168, Blast_Score=597, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI71988080, Length=505, Percent_Identity=56.8316831683168, Blast_Score=595, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71988074, Length=505, Percent_Identity=52.2772277227723, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17570191, Length=354, Percent_Identity=29.0960451977401, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17510931, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144756, Length=408, Percent_Identity=26.2254901960784, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=62, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=42.1052631578947, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=245, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=509, Percent_Identity=56.5815324165029, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319603, Length=340, Percent_Identity=28.8235294117647, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322581, Length=383, Percent_Identity=27.154046997389, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=56.8316831683168, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI281361666, Length=356, Percent_Identity=28.6516853932584, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24646341, Length=356, Percent_Identity=28.6516853932584, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17136796, Length=356, Percent_Identity=28.6516853932584, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24638766, Length=395, Percent_Identity=27.3417721518987, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28574560, Length=389, Percent_Identity=26.7352185089974, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24583988, Length=246, Percent_Identity=28.8617886178862, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583986, Length=246, Percent_Identity=28.8617886178862, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583984, Length=246, Percent_Identity=28.8617886178862, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583992, Length=246, Percent_Identity=28.8617886178862, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129479, Length=239, Percent_Identity=28.8702928870293, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_PARUW (Q6MAK5)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008669.1
- ProteinModelPortal:   Q6MAK5
- SMR:   Q6MAK5
- STRING:   Q6MAK5
- GeneID:   2779806
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1670
- NMPDR:   fig|264201.1.peg.1670
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   Q6MAK5
- ProtClustDB:   PRK09281
- BioCyc:   CPRO264201:PC1670-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 56264; Mature: 56264

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNPEEVSWVIQQEIEKYHEDLSLKFESAGRVLYVGDGIARVWGLDDVMMSELVEFPDG
CCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHHHCCHHHHHHHHHHCCCC
TLGIVLNLEIDNVGVIILGSDRNIREQDIVKRTGKIASVPVGEGMLGRVINALGQPIDGK
CEEEEEEEEECCEEEEEECCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCC
GAIETKEFRAIESSAPGVVQRKPVNEPVQTGIKAIDSMIPIGRGQRELIIGDRQTGKTTV
CCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEE
ILDTIINQKNTGVCCIYVAIGQKSSTIAQVVKILEEHDAMKYTIIVAATASDPAALQYVA
EEEEHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEEEC
PYSATALGEHFMYNGKHVICFYDDLSKHAQAYREIALLLRRPPGREAYPGDIFYLHSRLL
CCCHHHHHHHHEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERSAKLSTELGGGSLTAVPVIETQANDVTTYIPTNVISITDGQIYLESDLFYAGVRPAIN
HHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEECCEEEECCCCHHC
VGISASRVGGKAQSKAMKKVAASLRLDLAQYRELAAFAQFGSEMDKTTQAQLVRGERMIE
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKQDKFKPISLSKQVMIIFTGTKGFLDDLPLPFIKNFENEFYLFMDENHPHISNSIEQS
HHHHCCCCCCCCCCEEEEEEECCCCCHHCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
LDLDQKTMEQLNEAVTKFKSDFKLRYQI
CCCCHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MRLNPEEVSWVIQQEIEKYHEDLSLKFESAGRVLYVGDGIARVWGLDDVMMSELVEFPDG
CCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHHHCCHHHHHHHHHHCCCC
TLGIVLNLEIDNVGVIILGSDRNIREQDIVKRTGKIASVPVGEGMLGRVINALGQPIDGK
CEEEEEEEEECCEEEEEECCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCC
GAIETKEFRAIESSAPGVVQRKPVNEPVQTGIKAIDSMIPIGRGQRELIIGDRQTGKTTV
CCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEE
ILDTIINQKNTGVCCIYVAIGQKSSTIAQVVKILEEHDAMKYTIIVAATASDPAALQYVA
EEEEHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEEEC
PYSATALGEHFMYNGKHVICFYDDLSKHAQAYREIALLLRRPPGREAYPGDIFYLHSRLL
CCCHHHHHHHHEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERSAKLSTELGGGSLTAVPVIETQANDVTTYIPTNVISITDGQIYLESDLFYAGVRPAIN
HHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEECCEEEECCCCHHC
VGISASRVGGKAQSKAMKKVAASLRLDLAQYRELAAFAQFGSEMDKTTQAQLVRGERMIE
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKQDKFKPISLSKQVMIIFTGTKGFLDDLPLPFIKNFENEFYLFMDENHPHISNSIEQS
HHHHCCCCCCCCCCEEEEEEECCCCCHHCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
LDLDQKTMEQLNEAVTKFKSDFKLRYQI
CCCCHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA