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The map label for this gene is glmS [H]

Identifier: 46446940

GI number: 46446940

Start: 1561129

End: 1562952

Strand: Reverse

Name: glmS [H]

Synonym: pc1306

Alternate gene names: 46446940

Gene position: 1562952-1561129 (Counterclockwise)

Preceding gene: 46446941

Following gene: 46446939

Centisome position: 64.73

GC content: 37.99

Gene sequence:

>1824_bases
ATGTGTGGAATATTTGGTTATGTGGGAATAAAAGATCCCATCAAAATGGTATTAGATGGACTTAAAAAGCTTGAATATCG
GGGATATGATTCCGCAGGATTAGCCGGAGTAGAAAATGGGCAAATCGTTGCTTGTAAAGAAGTCGGTAAAGTAGCCTCGC
TTGAGCGAGAAGTTTTGCAGATGCATTTAGCTCCTAAGATGGCTATTGCACAAACGCGCTGGGCTACACATGGTGCTGTG
ACTAAAGTAAACGCACATCCTCACTTTGATCATGTTAAGTCAATTGCAGTCGTGCATAACGGAATTATTGAAAATTACGA
TATTTTGAAAAAAAAATTAATTGAAAAGGGAATTCAATTTGTTTCAGATACTGATACGGAAGTCATTGCTCATTTAATTG
CTCACCATTATGCAGGAGATTTACTCAATGCTGTTCAACAAACTGTCATTGAATTAAAGGGAGCTTATGCAGTTGCTGTT
GTTCACAAAGATTTCCCAGATCAGATCATTGCGATTGCTCATGAATGTCCTCTAGTGATTGGAATTGGAAACAACGAAGC
TTTTGTTTCGTCAGATCCTAATGCCTTTGCTTTTTACACTCGCCAAGCAATTTACTTATCTAATTCTGAAATAGCTGTAA
TTAAAGCAGGAAGTCAACAAGTTTACAATATCCATCATAAAATCACTAAAGAAAGTCAATTCATTGAAGGAGATTTAGAG
CAGATCTCAAAAGGTTCTTTCGAACACTTTACTCTTAAGGAAATCTATGAGCAACCCCAAGCGATTAGAAATGCGTTGCT
TTCTCGTATCCTGCCTGAATATGGAACAGCTTTATTTGAAGAACTCGATTTTAATATGACTGATTTGTTAACGGTCGAAC
GTATTTTGATTTTGGCTTGTGGAACTTCTTGGCACGCTGGCTGTGTCGCTGCTTACCTAATTGAAGATAAGGCGCGGATT
CCTGTACAAGTAGAGATTTCTTCTGAATTTCGTTATAAAAATCCTGTTGTTCCTCCAGGAACTTTTGTCATTGCTATTAG
CCAATCAGGAGAAACTGCCGATACAATCGCAGCCGTTAAAGAAGTCAAGGCAAAAGGAGCTCGCGTATTAGCGTTATGTA
ATGTACAAGGCTCTACATTAACGAGAGAGGCCGATGAGACCATTTTTTTGAAAGCGGGTGCTGAAATTGGAGTTTGCTCC
ACTAAAGCATTTACTAGTCAGGTTGTTGTTCTTGCCTTATTTACTCTTCTTTTAGCTCGGATGCGTCATATGAGTAAAGG
AGAAGGGCAGGATTTTCTAGAGGCTATTTTAAAGCTTCCAGACCAAGTACAAATGGTTTTAGATCAATCAATCGCGATTG
AGAGAATTGCAAAAAAATATGCTGGATTTGACAACTTTTTTTATCTTGGACGGCGTTATATGTTTCCGACAAGTTTAGAA
GGAGCACTTAAGTTAAAAGAAATTTCTTATATTAATGCCAATGGTTATGCAGCGGGTGAAATGAAGCATGGACCGATTGC
GCTTATTAATGAAGATTGCCCTACTGTCGCTCTTTGTGCTAACCGTCAAACATTTGAAAAACTACTTAGCAACTTAATGG
AAATTAAAGCAAGGCATGGAAAAATCATTGCGATTGTTGAAGAGCAGGAGAAGGCAATAGAAAAAATCGCGGATGATGTT
ATTTATATTCCCCACGTCATTGATGAGTTAGCAAGTATTTTAACAACTGTTGTAACCCAATTATTAGCTTATTATATAGC
CAAAGAAAGAGGAGCAGATATTGATCACCCTCGCAATTTGGCAAAATCTGTGACAGTTGAGTAA

Upstream 100 bases:

>100_bases
TAAACAAGTCATTCAATTGGCAAATCAAATTGCTGACATTGTGCAAGAAGAAATTGGATTGTCAGTTTCATAATTATACC
ATTGAGAAAAAGGGAACAGT

Downstream 100 bases:

>100_bases
AAAATAAATATTATGAATTTAAATTAGTGAAATGGATCATGGATCATCAGAAAGGTAGCATCTTAAACGGCTCATTGCTT
GTCGCAGGAACATCGATTGG

Product: glutamine-fructose-6-phosphate transaminase (isomerizing)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIFGYVGIKDPIKMVLDGLKKLEYRGYDSAGLAGVENGQIVACKEVGKVASLEREVLQMHLAPKMAIAQTRWATHGAV
TKVNAHPHFDHVKSIAVVHNGIIENYDILKKKLIEKGIQFVSDTDTEVIAHLIAHHYAGDLLNAVQQTVIELKGAYAVAV
VHKDFPDQIIAIAHECPLVIGIGNNEAFVSSDPNAFAFYTRQAIYLSNSEIAVIKAGSQQVYNIHHKITKESQFIEGDLE
QISKGSFEHFTLKEIYEQPQAIRNALLSRILPEYGTALFEELDFNMTDLLTVERILILACGTSWHAGCVAAYLIEDKARI
PVQVEISSEFRYKNPVVPPGTFVIAISQSGETADTIAAVKEVKAKGARVLALCNVQGSTLTREADETIFLKAGAEIGVCS
TKAFTSQVVVLALFTLLLARMRHMSKGEGQDFLEAILKLPDQVQMVLDQSIAIERIAKKYAGFDNFFYLGRRYMFPTSLE
GALKLKEISYINANGYAAGEMKHGPIALINEDCPTVALCANRQTFEKLLSNLMEIKARHGKIIAIVEEQEKAIEKIADDV
IYIPHVIDELASILTTVVTQLLAYYIAKERGADIDHPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIFGYVGIKDPIKMVLDGLKKLEYRGYDSAGLAGVENGQIVACKEVGKVASLEREVLQMHLAPKMAIAQTRWATHGAV
TKVNAHPHFDHVKSIAVVHNGIIENYDILKKKLIEKGIQFVSDTDTEVIAHLIAHHYAGDLLNAVQQTVIELKGAYAVAV
VHKDFPDQIIAIAHECPLVIGIGNNEAFVSSDPNAFAFYTRQAIYLSNSEIAVIKAGSQQVYNIHHKITKESQFIEGDLE
QISKGSFEHFTLKEIYEQPQAIRNALLSRILPEYGTALFEELDFNMTDLLTVERILILACGTSWHAGCVAAYLIEDKARI
PVQVEISSEFRYKNPVVPPGTFVIAISQSGETADTIAAVKEVKAKGARVLALCNVQGSTLTREADETIFLKAGAEIGVCS
TKAFTSQVVVLALFTLLLARMRHMSKGEGQDFLEAILKLPDQVQMVLDQSIAIERIAKKYAGFDNFFYLGRRYMFPTSLE
GALKLKEISYINANGYAAGEMKHGPIALINEDCPTVALCANRQTFEKLLSNLMEIKARHGKIIAIVEEQEKAIEKIADDV
IYIPHVIDELASILTTVVTQLLAYYIAKERGADIDHPRNLAKSVTVE
>Mature_607_residues
MCGIFGYVGIKDPIKMVLDGLKKLEYRGYDSAGLAGVENGQIVACKEVGKVASLEREVLQMHLAPKMAIAQTRWATHGAV
TKVNAHPHFDHVKSIAVVHNGIIENYDILKKKLIEKGIQFVSDTDTEVIAHLIAHHYAGDLLNAVQQTVIELKGAYAVAV
VHKDFPDQIIAIAHECPLVIGIGNNEAFVSSDPNAFAFYTRQAIYLSNSEIAVIKAGSQQVYNIHHKITKESQFIEGDLE
QISKGSFEHFTLKEIYEQPQAIRNALLSRILPEYGTALFEELDFNMTDLLTVERILILACGTSWHAGCVAAYLIEDKARI
PVQVEISSEFRYKNPVVPPGTFVIAISQSGETADTIAAVKEVKAKGARVLALCNVQGSTLTREADETIFLKAGAEIGVCS
TKAFTSQVVVLALFTLLLARMRHMSKGEGQDFLEAILKLPDQVQMVLDQSIAIERIAKKYAGFDNFFYLGRRYMFPTSLE
GALKLKEISYINANGYAAGEMKHGPIALINEDCPTVALCANRQTFEKLLSNLMEIKARHGKIIAIVEEQEKAIEKIADDV
IYIPHVIDELASILTTVVTQLLAYYIAKERGADIDHPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=33.5777126099707, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=33.7243401759531, Blast_Score=387, Evalue=1e-107,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=44.1558441558442, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1788651, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=35.9628770301624, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=35.4988399071926, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=35.4988399071926, Blast_Score=271, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322745, Length=717, Percent_Identity=31.3807531380753, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=29.3706293706294, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.0731707317073, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=33.6244541484716, Blast_Score=393, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66936; Mature: 66936

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00443 GATASE_TYPE_II ; PS00205 TRANSFERRIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFGYVGIKDPIKMVLDGLKKLEYRGYDSAGLAGVENGQIVACKEVGKVASLEREVLQ
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
MHLAPKMAIAQTRWATHGAVTKVNAHPHFDHVKSIAVVHNGIIENYDILKKKLIEKGIQF
HHCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHH
VSDTDTEVIAHLIAHHYAGDLLNAVQQTVIELKGAYAVAVVHKDFPDQIIAIAHECPLVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCEEE
GIGNNEAFVSSDPNAFAFYTRQAIYLSNSEIAVIKAGSQQVYNIHHKITKESQFIEGDLE
EECCCCEEECCCCCEEEEEEEEEEEEECCCEEEEECCCHHHHHHHHHHHCCHHHHHCCHH
QISKGSFEHFTLKEIYEQPQAIRNALLSRILPEYGTALFEELDFNMTDLLTVERILILAC
HHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
GTSWHAGCVAAYLIEDKARIPVQVEISSEFRYKNPVVPPGTFVIAISQSGETADTIAAVK
CCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
EVKAKGARVLALCNVQGSTLTREADETIFLKAGAEIGVCSTKAFTSQVVVLALFTLLLAR
HHHHCCCEEEEEEECCCCCEECCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
MRHMSKGEGQDFLEAILKLPDQVQMVLDQSIAIERIAKKYAGFDNFFYLGRRYMFPTSLE
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
GALKLKEISYINANGYAAGEMKHGPIALINEDCPTVALCANRQTFEKLLSNLMEIKARHG
CCEEEEEEEEECCCCEEECCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCC
KIIAIVEEQEKAIEKIADDVIYIPHVIDELASILTTVVTQLLAYYIAKERGADIDHPRNL
CEEEEECHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIFGYVGIKDPIKMVLDGLKKLEYRGYDSAGLAGVENGQIVACKEVGKVASLEREVLQ
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
MHLAPKMAIAQTRWATHGAVTKVNAHPHFDHVKSIAVVHNGIIENYDILKKKLIEKGIQF
HHCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHH
VSDTDTEVIAHLIAHHYAGDLLNAVQQTVIELKGAYAVAVVHKDFPDQIIAIAHECPLVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCEEE
GIGNNEAFVSSDPNAFAFYTRQAIYLSNSEIAVIKAGSQQVYNIHHKITKESQFIEGDLE
EECCCCEEECCCCCEEEEEEEEEEEEECCCEEEEECCCHHHHHHHHHHHCCHHHHHCCHH
QISKGSFEHFTLKEIYEQPQAIRNALLSRILPEYGTALFEELDFNMTDLLTVERILILAC
HHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
GTSWHAGCVAAYLIEDKARIPVQVEISSEFRYKNPVVPPGTFVIAISQSGETADTIAAVK
CCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
EVKAKGARVLALCNVQGSTLTREADETIFLKAGAEIGVCSTKAFTSQVVVLALFTLLLAR
HHHHCCCEEEEEEECCCCCEECCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
MRHMSKGEGQDFLEAILKLPDQVQMVLDQSIAIERIAKKYAGFDNFFYLGRRYMFPTSLE
HHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
GALKLKEISYINANGYAAGEMKHGPIALINEDCPTVALCANRQTFEKLLSNLMEIKARHG
CCEEEEEEEEECCCCEEECCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCC
KIIAIVEEQEKAIEKIADDVIYIPHVIDELASILTTVVTQLLAYYIAKERGADIDHPRNL
CEEEEECHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]