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The map label for this gene is tyrP_4 [H]

Identifier: 46446939

GI number: 46446939

Start: 1559888

End: 1561102

Strand: Reverse

Name: tyrP_4 [H]

Synonym: pc1305

Alternate gene names: 46446939

Gene position: 1561102-1559888 (Counterclockwise)

Preceding gene: 46446940

Following gene: 46446937

Centisome position: 64.66

GC content: 35.31

Gene sequence:

>1215_bases
GTGAAATGGATCATGGATCATCAGAAAGGTAGCATCTTAAACGGCTCATTGCTTGTCGCAGGAACATCGATTGGAGGAGG
AATGTTGGCTTTGCCAGTTTTAACAAGTTTGGCTGGCTTTTTTCCCTCTCTTGCTATTTATTTATTATGTTGGCTTTTCA
TGGCTTGTACAGGCCTTTTATTTTTAGAGGTTTCTCAATGGATTAAAGGGGAATCGAACATCATTACTATGGCTGAAAAA
ACGCTTGGAAAAGGAGGGCGCTATTTTGCTTGGATTGTTTATTTATTCTTATTCTATTGTTTAACGATTGCCTATATGGT
TGGTTGCGGCAATATTGTTGTAGAGTTTTCTCAATCTACAATTCCAGATTGGCTAGGACCAATTATTTTTGTTCTTTTAT
TTTCTCCTCTTATTTTAATTCCTACCGCTTGGGCAGGTCGTTTAAATGTCTGGCTTATTATAGGTCTTGCTTTGTCTTAT
TTAGGATTTGTTTTATTAGGATTTCGTCATGTCGACCTAAATTTTTTGAGGGATTACAATTGGTCTTATTCTTTAATGGT
GTTACCTATTGCCTTTACCTCATTTGCTTATCAAGGAATTATTCCAACGCTTGCGAGTTATTTGCATCACGATGCTAAAG
CCATTCGAACATCAATTTTAATTGGAAGTTTTATTCCATTAATTGCTTATATTATTTGGGAAGGACTTATCTTAGGTATT
GTGCCTAAAGAAGGCGCAGGAGGACTCATAGAAGCTTTAAAAAATGGGAATAATGCTGTTCATCCTTTAAAAAATTTTAT
TCATAATCCTGCTGTTTATTACTTAGGGCAAGCTTTTGCTTTTTTTGCTCTGATTACTTCTTTTTTAGGTGTGACGTTAG
GTTTAAGAGATTTTTTGGCAGATGGTTTGAATATTCATAAAAATATCAAAGGCAAAATGCTTTTAGCTTTACTTATCTTT
GCTTTTCCTCTCCTCATTTCTGTGAGTTACCCCCATATCTTTTTAATTGCTTTAGATTATGCAGGGGGATTTGGAGTTGC
TCTTTTATTAGGTCTTCTTCCCATTTTAATGACTTGGATTGGGCGTTATCGACAAAGATTAGAGACAAACCAACAATTAC
CTGGAGGCAAAATGTCACTGGTCTTGCTCGGTGGATTTGTTGTTTTTGAACTCTTTCACGAAACAAAGCATTTAATTGAC
AGGATATTTTCATAA

Upstream 100 bases:

>100_bases
ATTATATAGCCAAAGAAAGAGGAGCAGATATTGATCACCCTCGCAATTTGGCAAAATCTGTGACAGTTGAGTAAAAAATA
AATATTATGAATTTAAATTA

Downstream 100 bases:

>100_bases
ATAAAAAACCCAAAAAGAAAGAAATTTTACTCTCTTCTTTTCGGGTCGTTGGCAATTTATAGGATTGCCTTAAGATATCG
ATGTTGCTACCTTAGGTAAG

Product: putative tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKWIMDHQKGSILNGSLLVAGTSIGGGMLALPVLTSLAGFFPSLAIYLLCWLFMACTGLLFLEVSQWIKGESNIITMAEK
TLGKGGRYFAWIVYLFLFYCLTIAYMVGCGNIVVEFSQSTIPDWLGPIIFVLLFSPLILIPTAWAGRLNVWLIIGLALSY
LGFVLLGFRHVDLNFLRDYNWSYSLMVLPIAFTSFAYQGIIPTLASYLHHDAKAIRTSILIGSFIPLIAYIIWEGLILGI
VPKEGAGGLIEALKNGNNAVHPLKNFIHNPAVYYLGQAFAFFALITSFLGVTLGLRDFLADGLNIHKNIKGKMLLALLIF
AFPLLISVSYPHIFLIALDYAGGFGVALLLGLLPILMTWIGRYRQRLETNQQLPGGKMSLVLLGGFVVFELFHETKHLID
RIFS

Sequences:

>Translated_404_residues
MKWIMDHQKGSILNGSLLVAGTSIGGGMLALPVLTSLAGFFPSLAIYLLCWLFMACTGLLFLEVSQWIKGESNIITMAEK
TLGKGGRYFAWIVYLFLFYCLTIAYMVGCGNIVVEFSQSTIPDWLGPIIFVLLFSPLILIPTAWAGRLNVWLIIGLALSY
LGFVLLGFRHVDLNFLRDYNWSYSLMVLPIAFTSFAYQGIIPTLASYLHHDAKAIRTSILIGSFIPLIAYIIWEGLILGI
VPKEGAGGLIEALKNGNNAVHPLKNFIHNPAVYYLGQAFAFFALITSFLGVTLGLRDFLADGLNIHKNIKGKMLLALLIF
AFPLLISVSYPHIFLIALDYAGGFGVALLLGLLPILMTWIGRYRQRLETNQQLPGGKMSLVLLGGFVVFELFHETKHLID
RIFS
>Mature_404_residues
MKWIMDHQKGSILNGSLLVAGTSIGGGMLALPVLTSLAGFFPSLAIYLLCWLFMACTGLLFLEVSQWIKGESNIITMAEK
TLGKGGRYFAWIVYLFLFYCLTIAYMVGCGNIVVEFSQSTIPDWLGPIIFVLLFSPLILIPTAWAGRLNVWLIIGLALSY
LGFVLLGFRHVDLNFLRDYNWSYSLMVLPIAFTSFAYQGIIPTLASYLHHDAKAIRTSILIGSFIPLIAYIIWEGLILGI
VPKEGAGGLIEALKNGNNAVHPLKNFIHNPAVYYLGQAFAFFALITSFLGVTLGLRDFLADGLNIHKNIKGKMLLALLIF
AFPLLISVSYPHIFLIALDYAGGFGVALLLGLLPILMTWIGRYRQRLETNQQLPGGKMSLVLLGGFVVFELFHETKHLID
RIFS

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=385, Percent_Identity=31.6883116883117, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789552, Length=346, Percent_Identity=30.3468208092486, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790145, Length=349, Percent_Identity=29.512893982808, Blast_Score=118, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44736; Mature: 44736

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWIMDHQKGSILNGSLLVAGTSIGGGMLALPVLTSLAGFFPSLAIYLLCWLFMACTGLL
CCCCCCCCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEVSQWIKGESNIITMAEKTLGKGGRYFAWIVYLFLFYCLTIAYMVGCGNIVVEFSQST
HHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCC
IPDWLGPIIFVLLFSPLILIPTAWAGRLNVWLIIGLALSYLGFVLLGFRHVDLNFLRDYN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
WSYSLMVLPIAFTSFAYQGIIPTLASYLHHDAKAIRTSILIGSFIPLIAYIIWEGLILGI
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
VPKEGAGGLIEALKNGNNAVHPLKNFIHNPAVYYLGQAFAFFALITSFLGVTLGLRDFLA
ECCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLNIHKNIKGKMLLALLIFAFPLLISVSYPHIFLIALDYAGGFGVALLLGLLPILMTWI
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
GRYRQRLETNQQLPGGKMSLVLLGGFVVFELFHETKHLIDRIFS
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKWIMDHQKGSILNGSLLVAGTSIGGGMLALPVLTSLAGFFPSLAIYLLCWLFMACTGLL
CCCCCCCCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLEVSQWIKGESNIITMAEKTLGKGGRYFAWIVYLFLFYCLTIAYMVGCGNIVVEFSQST
HHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCC
IPDWLGPIIFVLLFSPLILIPTAWAGRLNVWLIIGLALSYLGFVLLGFRHVDLNFLRDYN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
WSYSLMVLPIAFTSFAYQGIIPTLASYLHHDAKAIRTSILIGSFIPLIAYIIWEGLILGI
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
VPKEGAGGLIEALKNGNNAVHPLKNFIHNPAVYYLGQAFAFFALITSFLGVTLGLRDFLA
ECCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLNIHKNIKGKMLLALLIFAFPLLISVSYPHIFLIALDYAGGFGVALLLGLLPILMTWI
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
GRYRQRLETNQQLPGGKMSLVLLGGFVVFELFHETKHLIDRIFS
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]