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The map label for this gene is mraY

Identifier: 46446886

GI number: 46446886

Start: 1493247

End: 1494479

Strand: Reverse

Name: mraY

Synonym: pc1252

Alternate gene names: 46446886

Gene position: 1494479-1493247 (Counterclockwise)

Preceding gene: 46446887

Following gene: 46446885

Centisome position: 61.9

GC content: 36.01

Gene sequence:

>1233_bases
ATGATTTTGTTTGCAATTGATTACTTGGAAAGGGTTTGGACTCTAAAAGTTCCAAGCGTCTTTAGTTATTATTCTACAAG
AATGATTCTTGCCGCAATTACTTCTCTTCTATTGAGTATTTTTTTAGGGCCTTATTTTATCCGTAAACTTTATGAGTTAA
AAATCGGTCAGTCAATTCGAAAAGAAGATTGCCCCTTGCTGGGACAATTACATGAGAAGAAACAAAACACTCCCACAATG
GGAGGAATTCTTATTCTTTCTTCTATGTTGGTTTCATTAGTTTTATGGATGGATTTAACACATATTTTCACACTCATTTT
GTTTGTCACAACTGTATTTTTAGGTTTGATTGGAGGAAGAGACGATTATCTCAAATTGAAATATAAAAATACCAAAGGGA
TGTCAGCACGAGGAAAATTATTTTTTCAATTTGTTTTATCCGCTGCAATTGCTTCTTATTTTTTATTGAGTTCAGTTAAT
GAAATGTTTGAGAAGTGGACATGGTTTCAACCTCCCGTAATTAAAGAGCAGATTGTTGTTAAAAATTCTGAAACTTTACA
AGAGATGCCTTCTCAAACTAAAAGCATTAGTTTGAAAGAATACGCTTCGAGACTCTACATTCCCTTTTTTAAAGAGCCTG
TTGTTACGTTTGGAGGTATTTCTCTTATTCTCATGGCTTTTTTCATTTTTTTTGTGATCACAGGATCTTCAAATGCCGCT
AATTTGACCGATGGCTTAGATGGATTGTTGGCTGGTTGTTTGGTTACAGCGGCAGGATCCCTTTGCTTGATCGCTTTTGT
TTCCAATCATGTGGATATTGCTCGTTACCTCAACATCCTTTACATCGAAGGAAGTGGAGAAATAGCCATTTATCTTTGCG
CCTTAATCGGAGCAAGCTTAGGATTTTTATGGTATAATGGTTATCCTGCACAAGTCTTTATGGGAGATACAGGTTCTTTG
ACATTAGGGGGAATTTTAGGCGTCTCAGCAGTGCTGTTGCGCAGAGAGTTTCTTTTAGGGATTGTTGGAGGGATTTTTGT
TGCCGAAGCACTTTCCGTTATTCTTCAAGTGGCTAGCTATCGACTTAGAAATAAAAAAAGAATTTTCCTTTGTGCGCCTT
TGCATCATCATTTCGAATATAAAGGATGGCCCGAAACTAAAGTTGTGATTCGATTTTGGATCATGAGTTTACTCTTTGCT
ATCATTGGCATTGCCTCTTTAAAATTTCAATAA

Upstream 100 bases:

>100_bases
ACTTAAAACCCGCCGATGTTGTTTTATTGAAAGGATCTAGATCCAAAGAGTTGTGGAAAATATTAGAAGAACTGTAAAAA
ATAACTAAAGAGCTTTATTT

Downstream 100 bases:

>100_bases
AGGATTGATAACAGATGCCGATAGAAAATTACTTTGGGAAAAAAGCGCTCATCATTGGATTAGGGGTAAGTGGAAGAGCC
GCGGCTTCTTTCTTGCAAAC

Product: putative phospho-N-acetylmuramoyl-pentapeptide-transferase mraY

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MILFAIDYLERVWTLKVPSVFSYYSTRMILAAITSLLLSIFLGPYFIRKLYELKIGQSIRKEDCPLLGQLHEKKQNTPTM
GGILILSSMLVSLVLWMDLTHIFTLILFVTTVFLGLIGGRDDYLKLKYKNTKGMSARGKLFFQFVLSAAIASYFLLSSVN
EMFEKWTWFQPPVIKEQIVVKNSETLQEMPSQTKSISLKEYASRLYIPFFKEPVVTFGGISLILMAFFIFFVITGSSNAA
NLTDGLDGLLAGCLVTAAGSLCLIAFVSNHVDIARYLNILYIEGSGEIAIYLCALIGASLGFLWYNGYPAQVFMGDTGSL
TLGGILGVSAVLLRREFLLGIVGGIFVAEALSVILQVASYRLRNKKRIFLCAPLHHHFEYKGWPETKVVIRFWIMSLLFA
IIGIASLKFQ

Sequences:

>Translated_410_residues
MILFAIDYLERVWTLKVPSVFSYYSTRMILAAITSLLLSIFLGPYFIRKLYELKIGQSIRKEDCPLLGQLHEKKQNTPTM
GGILILSSMLVSLVLWMDLTHIFTLILFVTTVFLGLIGGRDDYLKLKYKNTKGMSARGKLFFQFVLSAAIASYFLLSSVN
EMFEKWTWFQPPVIKEQIVVKNSETLQEMPSQTKSISLKEYASRLYIPFFKEPVVTFGGISLILMAFFIFFVITGSSNAA
NLTDGLDGLLAGCLVTAAGSLCLIAFVSNHVDIARYLNILYIEGSGEIAIYLCALIGASLGFLWYNGYPAQVFMGDTGSL
TLGGILGVSAVLLRREFLLGIVGGIFVAEALSVILQVASYRLRNKKRIFLCAPLHHHFEYKGWPETKVVIRFWIMSLLFA
IIGIASLKFQ
>Mature_410_residues
MILFAIDYLERVWTLKVPSVFSYYSTRMILAAITSLLLSIFLGPYFIRKLYELKIGQSIRKEDCPLLGQLHEKKQNTPTM
GGILILSSMLVSLVLWMDLTHIFTLILFVTTVFLGLIGGRDDYLKLKYKNTKGMSARGKLFFQFVLSAAIASYFLLSSVN
EMFEKWTWFQPPVIKEQIVVKNSETLQEMPSQTKSISLKEYASRLYIPFFKEPVVTFGGISLILMAFFIFFVITGSSNAA
NLTDGLDGLLAGCLVTAAGSLCLIAFVSNHVDIARYLNILYIEGSGEIAIYLCALIGASLGFLWYNGYPAQVFMGDTGSL
TLGGILGVSAVLLRREFLLGIVGGIFVAEALSVILQVASYRLRNKKRIFLCAPLHHHFEYKGWPETKVVIRFWIMSLLFA
IIGIASLKFQ

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=392, Percent_Identity=43.3673469387755, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_PARUW (Q6MBS3)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008251.1
- STRING:   Q6MBS3
- GeneID:   2780217
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1252
- NMPDR:   fig|264201.1.peg.1252
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q6MBS3
- ProtClustDB:   CLSK2762360
- BioCyc:   CPRO264201:PC1252-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 45905; Mature: 45905

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd525850)-; HASH(0xe6e6dc8)-; HASH(0xe6d9830)-; HASH(0xe6d45ec)-; HASH(0xe6e28cc)-; HASH(0xe6d9530)-; HASH(0xe6d7380)-; HASH(0xe6e6c00)-; HASH(0xe6d467c)-; HASH(0xe6e271c)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILFAIDYLERVWTLKVPSVFSYYSTRMILAAITSLLLSIFLGPYFIRKLYELKIGQSIR
CEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KEDCPLLGQLHEKKQNTPTMGGILILSSMLVSLVLWMDLTHIFTLILFVTTVFLGLIGGR
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDYLKLKYKNTKGMSARGKLFFQFVLSAAIASYFLLSSVNEMFEKWTWFQPPVIKEQIVV
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEE
KNSETLQEMPSQTKSISLKEYASRLYIPFFKEPVVTFGGISLILMAFFIFFVITGSSNAA
CCHHHHHHCCHHHHCCCHHHHHHHCCCCHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCC
NLTDGLDGLLAGCLVTAAGSLCLIAFVSNHVDIARYLNILYIEGSGEIAIYLCALIGASL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
GFLWYNGYPAQVFMGDTGSLTLGGILGVSAVLLRREFLLGIVGGIFVAEALSVILQVASY
HHHEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRNKKRIFLCAPLHHHFEYKGWPETKVVIRFWIMSLLFAIIGIASLKFQ
HHCCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MILFAIDYLERVWTLKVPSVFSYYSTRMILAAITSLLLSIFLGPYFIRKLYELKIGQSIR
CEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KEDCPLLGQLHEKKQNTPTMGGILILSSMLVSLVLWMDLTHIFTLILFVTTVFLGLIGGR
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDYLKLKYKNTKGMSARGKLFFQFVLSAAIASYFLLSSVNEMFEKWTWFQPPVIKEQIVV
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEE
KNSETLQEMPSQTKSISLKEYASRLYIPFFKEPVVTFGGISLILMAFFIFFVITGSSNAA
CCHHHHHHCCHHHHCCCHHHHHHHCCCCHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCC
NLTDGLDGLLAGCLVTAAGSLCLIAFVSNHVDIARYLNILYIEGSGEIAIYLCALIGASL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
GFLWYNGYPAQVFMGDTGSLTLGGILGVSAVLLRREFLLGIVGGIFVAEALSVILQVASY
HHHEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRNKKRIFLCAPLHHHFEYKGWPETKVVIRFWIMSLLFAIIGIASLKFQ
HHCCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA