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The map label for this gene is fabF [H]

Identifier: 46446872

GI number: 46446872

Start: 1474303

End: 1475559

Strand: Reverse

Name: fabF [H]

Synonym: pc1238

Alternate gene names: 46446872

Gene position: 1475559-1474303 (Counterclockwise)

Preceding gene: 46446873

Following gene: 46446871

Centisome position: 61.11

GC content: 40.41

Gene sequence:

>1257_bases
TTGAGGAAAATGAGCAAAAAACGAATTGTCATTACAGGAATGGGTATTGTTTCATGTTTTGGAAACGATGTTGATGCTTT
TTATCAAAATCTTTTAGCCGGTCAGAGTGGTATTCAACCTATCACAGAATTCCCATGTGAAGATTATCCAACGCGATTTG
CTGGAATTATCCCCAATTTTGAAGCTGGTGAGTATTTAGACAAAAAGCAGGCTCGTCGAGTGGATAAATCGATTGCTTAT
ACGATGGTAGCAGGAAAAAAATCACTAGAATCAGCTAATTTAAATGAAGAAAACTTAAAAAGACTTCAAAAAGAACGGTG
CGGTATTTTGATTGGTTCTGGAATGGGAGGAATGACAATGTTTGCTGATGGAGTGCAAACATTAGTTGAAAAAGGACCTC
GAAAAGTATCTCCTTTTTTTGTTCCTTTTATTTTGACAAATATGTGTGGGGCGTTGCTGGGAATAGATATTGGTTTTATG
GGCCCTAACTATTCTATTTCAACAGCTTGTGCTACCGCAAATAATTCGATTATTTCTGCTGCTCAACACATCAGAAATGG
AGAGGCTGATTTGATGCTGTGTGGAGGTGTAGAAGCGGCTGTGATGCCGATGGGATTAGCAGGTTTTTGCGCATGTAAAG
CCCTTTCTCAACGAAACGAAAATCCAGCTAAAGCTTCTCGCCCTTGGGATCAGGGAAGAGATGGTTTCGTCCTTGGTGAA
GGAGCTGGTGTTCTTGTGATGGAAAGTTTAGATCACGCTTTAGCTCGAGAAGCACCTATTTTGGCTGAGTATTTAGGAGG
TGGATTGTCGTGTGATGCTTATCATATGACAGAGCCACGTTCAGACGGAGAGGGTGTTGCTTTATGTATTCGCAGAGCTT
TACAGGATGCAGGAATCCAACCCGAAGAGATTAATTATATTAATGCTCATGCCACTTCTACTCCTGCGGGAGATATGGCT
GAGGTTAATGCCCTAAAAAAAGTTTTTAAAAACCCTTCTTCGATCAAAATGAACGCAACAAAATCGATGATAGGTCACTT
GTTAGGCGCTGCAGGTGGGGTGGAAGCAATTGCGACAATTAAAGCGATTCTTGAACATCAAATTCATCCAACCATTAATT
TAGAAAACCCAGAACCTAATTTAGAATTTGATGTTTCATCCGAGGCGCAACGATTTATCGTGAAACGTGCGATTTCTAAT
TCGTTTGGCTTTGGAGGTCATAATGCTTCTGTTATTTTTGCTCCTTATGAACCCTAG

Upstream 100 bases:

>100_bases
GAGTTTAAAAGAGCTTAACATGTTTATGCATTCATAAAAGAAAACGATTGCCGTTTGTGAGAAAAGTAGTAGTTAACCTT
TTTAAACCAATCTAAAAGGA

Downstream 100 bases:

>100_bases
ACGCTAAAATGCCCTTAAAAAAAGATTATTCTTACGGAATTATTCCCATTCAAAGAAAAGAAGATAAATGGTACGTATTG
CTCATTCAGCAGCAAGCGGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRKMSKKRIVITGMGIVSCFGNDVDAFYQNLLAGQSGIQPITEFPCEDYPTRFAGIIPNFEAGEYLDKKQARRVDKSIAY
TMVAGKKSLESANLNEENLKRLQKERCGILIGSGMGGMTMFADGVQTLVEKGPRKVSPFFVPFILTNMCGALLGIDIGFM
GPNYSISTACATANNSIISAAQHIRNGEADLMLCGGVEAAVMPMGLAGFCACKALSQRNENPAKASRPWDQGRDGFVLGE
GAGVLVMESLDHALAREAPILAEYLGGGLSCDAYHMTEPRSDGEGVALCIRRALQDAGIQPEEINYINAHATSTPAGDMA
EVNALKKVFKNPSSIKMNATKSMIGHLLGAAGGVEAIATIKAILEHQIHPTINLENPEPNLEFDVSSEAQRFIVKRAISN
SFGFGGHNASVIFAPYEP

Sequences:

>Translated_418_residues
MRKMSKKRIVITGMGIVSCFGNDVDAFYQNLLAGQSGIQPITEFPCEDYPTRFAGIIPNFEAGEYLDKKQARRVDKSIAY
TMVAGKKSLESANLNEENLKRLQKERCGILIGSGMGGMTMFADGVQTLVEKGPRKVSPFFVPFILTNMCGALLGIDIGFM
GPNYSISTACATANNSIISAAQHIRNGEADLMLCGGVEAAVMPMGLAGFCACKALSQRNENPAKASRPWDQGRDGFVLGE
GAGVLVMESLDHALAREAPILAEYLGGGLSCDAYHMTEPRSDGEGVALCIRRALQDAGIQPEEINYINAHATSTPAGDMA
EVNALKKVFKNPSSIKMNATKSMIGHLLGAAGGVEAIATIKAILEHQIHPTINLENPEPNLEFDVSSEAQRFIVKRAISN
SFGFGGHNASVIFAPYEP
>Mature_418_residues
MRKMSKKRIVITGMGIVSCFGNDVDAFYQNLLAGQSGIQPITEFPCEDYPTRFAGIIPNFEAGEYLDKKQARRVDKSIAY
TMVAGKKSLESANLNEENLKRLQKERCGILIGSGMGGMTMFADGVQTLVEKGPRKVSPFFVPFILTNMCGALLGIDIGFM
GPNYSISTACATANNSIISAAQHIRNGEADLMLCGGVEAAVMPMGLAGFCACKALSQRNENPAKASRPWDQGRDGFVLGE
GAGVLVMESLDHALAREAPILAEYLGGGLSCDAYHMTEPRSDGEGVALCIRRALQDAGIQPEEINYINAHATSTPAGDMA
EVNALKKVFKNPSSIKMNATKSMIGHLLGAAGGVEAIATIKAILEHQIHPTINLENPEPNLEFDVSSEAQRFIVKRAISN
SFGFGGHNASVIFAPYEP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=38.9021479713604, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=47.972972972973, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI41872631, Length=436, Percent_Identity=23.394495412844, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=46.5060240963855, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=36.5617433414044, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=36.7788461538462, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=43.0232558139535, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=425, Percent_Identity=24.7058823529412, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=358, Percent_Identity=22.9050279329609, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.7713004484305, Blast_Score=252, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=41.8052256532066, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24581345, Length=433, Percent_Identity=23.5565819861432, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920632, Length=268, Percent_Identity=28.3582089552239, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=27.5985663082437, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44756; Mature: 44756

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKMSKKRIVITGMGIVSCFGNDVDAFYQNLLAGQSGIQPITEFPCEDYPTRFAGIIPNF
CCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHCCCCC
EAGEYLDKKQARRVDKSIAYTMVAGKKSLESANLNEENLKRLQKERCGILIGSGMGGMTM
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCEEEECCCCCHHH
FADGVQTLVEKGPRKVSPFFVPFILTNMCGALLGIDIGFMGPNYSISTACATANNSIISA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHCCCHHHHH
AQHIRNGEADLMLCGGVEAAVMPMGLAGFCACKALSQRNENPAKASRPWDQGRDGFVLGE
HHHHCCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
GAGVLVMESLDHALAREAPILAEYLGGGLSCDAYHMTEPRSDGEGVALCIRRALQDAGIQ
CCCEEEHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
PEEINYINAHATSTPAGDMAEVNALKKVFKNPSSIKMNATKSMIGHLLGAAGGVEAIATI
CHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHH
KAILEHQIHPTINLENPEPNLEFDVSSEAQRFIVKRAISNSFGFGGHNASVIFAPYEP
HHHHHHCCCCCEEECCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MRKMSKKRIVITGMGIVSCFGNDVDAFYQNLLAGQSGIQPITEFPCEDYPTRFAGIIPNF
CCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHCCCCC
EAGEYLDKKQARRVDKSIAYTMVAGKKSLESANLNEENLKRLQKERCGILIGSGMGGMTM
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCEEEECCCCCHHH
FADGVQTLVEKGPRKVSPFFVPFILTNMCGALLGIDIGFMGPNYSISTACATANNSIISA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHCCCHHHHH
AQHIRNGEADLMLCGGVEAAVMPMGLAGFCACKALSQRNENPAKASRPWDQGRDGFVLGE
HHHHCCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
GAGVLVMESLDHALAREAPILAEYLGGGLSCDAYHMTEPRSDGEGVALCIRRALQDAGIQ
CCCEEEHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
PEEINYINAHATSTPAGDMAEVNALKKVFKNPSSIKMNATKSMIGHLLGAAGGVEAIATI
CHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHH
KAILEHQIHPTINLENPEPNLEFDVSSEAQRFIVKRAISNSFGFGGHNASVIFAPYEP
HHHHHHCCCCCEEECCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]