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The map label for this gene is copB [H]

Identifier: 46446443

GI number: 46446443

Start: 988555

End: 990849

Strand: Direct

Name: copB [H]

Synonym: pc0809

Alternate gene names: 46446443

Gene position: 988555-990849 (Clockwise)

Preceding gene: 46446440

Following gene: 46446447

Centisome position: 40.94

GC content: 36.03

Gene sequence:

>2295_bases
GTGCATCAAATTCTTGCCACTCAACAAGCGTTAAATAATGTTAGTGAACATCCTTTGTTTAAGCAAGCTTTGAAATCAGG
TTTGATCGCCAATCCGCGCCTTTTGGAAGAAATTAATAGTCAGAAAATAGGAGAGAAAGAGACGCTTGAAAAGCTACATT
TAGAAATTCACGATATGTGGTGTCCATCTTGTGCAGAAGTTATCAAGCTGACTCTTTTGAAAGAATGGGGGATTGCTTAT
TGCTACGTTGATTATACAACAGATTCGGCTACGATCGAATATGCTCCTGTTCATATCACAAAAGAAAGAATTTTAAAACT
CATCTCAAATTTGGGATATCGTCCAAATTTTTTGCAGGATCCTCGCCAACAAGTGTTGAGTCGAACTTTATCCCTTCGTT
TTGTTATCGCAGCATTTTTCTCAATGAATATTATGATGTTTGCTTATCCAATTTATGTCAGTTTTTTTAATGAACAAGCA
GAAGGATATGCCCAATTATTTGCTTGGCTTTCTTTGATAGGAGCACTACCAGTTTTAACCTATAGTGCTTGGCCAATATG
GAAAAGATTTTATACTGGTGCGAAAGTAGGGTTATGGGGAATGGAGGCTTTAGTTGTTTTAGGTGTAGCTGCAGCAACAG
GGCTATCTATTTATGAAATGTGGAGGGGGAGTTCGTATGTTTATTTTGATTCGATGACAGTTATCATTGTTTTCGTCTTG
TTAGGAAAAATGATTGAGTCGAAAGCCAAATTTTCTGCTAAAGATTCTCTTGTTCAATTGACAAGAGCGCTACCAAGACG
CGGGAGAAAAAAAATCTCTGCAACAAAAAATGAGTTTGTTTCTTTAAAAGAGATCCACATAGGCGATTTGCTGGTTGTTT
TGAGTGGTGAGAAAATTGTACTGGATGGAATTGTTGAAGAAGGAGAGGGGATTTGCAATGAATCTTTAATGACAGGAGAG
GCTTTACCAGTACCTAAAAATGTTGGGATGGATGTTTTAGCTGGAACGATTTTGCAACAGGGATCTTTGGTTATTAAAGT
GACTGCTACTTCTGAGCAAACTGCCCTCTTTCAAATCGTTGAAATGGTAGAGCAAGATATTGGTCATAAAGCTCAGTATG
TACGAACCATTGATTCGATTGTCAAATGGTTTGTTCCGTTTGTTTTATGTTTAGCGATTGGGGTTTTTGTTTACTGCTTA
CTATTTAATCAACAAGATTTTGATCAAACCTCTTTACAATCCGGAATTATTCGTGCTGTATCAGTTTTACTGATTTCATG
TCCATGTGCTATTGGAATTGCTGTTCCTTTAGTAGAATCTCAATTACTAAATGCATTTGCTAAGCTCGGAGTCATTATTC
GCAATCGAGCTTGTTTAGCTTTACTCGGTAAAGAAACAATTTTAGTTTGTGATAAAACAGGAACTGTTACAGAAGGAAAA
TATACTGTTTTAAGTGGCTATGAAAAGCTTTCTTTAGAAGAAAAAAGTGTTTTAAAAGCGTTAGTTTCTCATTCGAATCA
CCCCATCGCTCGATCAGTTGATCAAGCTATTATTGATTTTGAAGAGAGCAACATTGAAAAAATCGAAGAGATTATCGGAA
GAGGAATTAGGGGGTATCAAGGAAAAATCCCCTATTATTTTGGATCAGCCATTTTTTTACAACAACAGGGGATATCAACT
CCTTTAATTCATTTGAGAAAAAATATGGAGGCTCAAACGACAGTCTTTTTTGCTAAGCAAAATATTTGTTTAGCTGCTAT
TCATTTGGGAGATCGTATTCAACCAGAAGTACAAACGTTGATTCAATCTTTAAAAGGGATAAAAACATTGCTATTGTCAG
GAGACTCTTCATTAGCTGTTGAAGCCGTGGCTCGATTGTGCGGATTTCAGGAATGGTTTGCAGAATATCATCCACTTCAA
AAAAGAGAATTGATAGAAAAGCTAAAAAAACAGGGAGAAATTGTGATGATGATTGGTGATGGAATCAATGACGCTCCGGC
TTTGACAGCTTCTCATATAGGCGTTGCCGTTATGTCGGCGACTGATATTTCGATTCAGGTTTCTGATATTCTTTTAACAA
CCAATCGTTTACAAATATTACAAAAAATGCATCACTTGGCTAAAAAAGGACATAAAATTATTAAGCAAAATTTATTTTGG
GCTTTTTTTTACAATTGCATTGGTTTAGGATTAGCAGTTTACGGATCGTTAACCCCACTATTTGCGGCTTTTGCCATGGT
GATGAGCAGCTTACTTGTTTTAATTAATTCTAAAAGAGTCTATTTAAATAAATAG

Upstream 100 bases:

>100_bases
AAACTCTATGACATCTGAATGTTTACTTTGTCAAAGCCCTGTTAACCTTGTCTTCTATAAAGATGGAGAAAAAACATTTT
GCTGCGCAGGGTGTCAAACT

Downstream 100 bases:

>100_bases
ATATTCATTAAATTCTTCCATTAAGATGATTGATTCTTATCAATTAAAATTACAAAAGAATTAAATTTAATTGTTTAAGG
CAGTTTATGTTCATTTCGTC

Product: putative copper-transporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MHQILATQQALNNVSEHPLFKQALKSGLIANPRLLEEINSQKIGEKETLEKLHLEIHDMWCPSCAEVIKLTLLKEWGIAY
CYVDYTTDSATIEYAPVHITKERILKLISNLGYRPNFLQDPRQQVLSRTLSLRFVIAAFFSMNIMMFAYPIYVSFFNEQA
EGYAQLFAWLSLIGALPVLTYSAWPIWKRFYTGAKVGLWGMEALVVLGVAAATGLSIYEMWRGSSYVYFDSMTVIIVFVL
LGKMIESKAKFSAKDSLVQLTRALPRRGRKKISATKNEFVSLKEIHIGDLLVVLSGEKIVLDGIVEEGEGICNESLMTGE
ALPVPKNVGMDVLAGTILQQGSLVIKVTATSEQTALFQIVEMVEQDIGHKAQYVRTIDSIVKWFVPFVLCLAIGVFVYCL
LFNQQDFDQTSLQSGIIRAVSVLLISCPCAIGIAVPLVESQLLNAFAKLGVIIRNRACLALLGKETILVCDKTGTVTEGK
YTVLSGYEKLSLEEKSVLKALVSHSNHPIARSVDQAIIDFEESNIEKIEEIIGRGIRGYQGKIPYYFGSAIFLQQQGIST
PLIHLRKNMEAQTTVFFAKQNICLAAIHLGDRIQPEVQTLIQSLKGIKTLLLSGDSSLAVEAVARLCGFQEWFAEYHPLQ
KRELIEKLKKQGEIVMMIGDGINDAPALTASHIGVAVMSATDISIQVSDILLTTNRLQILQKMHHLAKKGHKIIKQNLFW
AFFYNCIGLGLAVYGSLTPLFAAFAMVMSSLLVLINSKRVYLNK

Sequences:

>Translated_764_residues
MHQILATQQALNNVSEHPLFKQALKSGLIANPRLLEEINSQKIGEKETLEKLHLEIHDMWCPSCAEVIKLTLLKEWGIAY
CYVDYTTDSATIEYAPVHITKERILKLISNLGYRPNFLQDPRQQVLSRTLSLRFVIAAFFSMNIMMFAYPIYVSFFNEQA
EGYAQLFAWLSLIGALPVLTYSAWPIWKRFYTGAKVGLWGMEALVVLGVAAATGLSIYEMWRGSSYVYFDSMTVIIVFVL
LGKMIESKAKFSAKDSLVQLTRALPRRGRKKISATKNEFVSLKEIHIGDLLVVLSGEKIVLDGIVEEGEGICNESLMTGE
ALPVPKNVGMDVLAGTILQQGSLVIKVTATSEQTALFQIVEMVEQDIGHKAQYVRTIDSIVKWFVPFVLCLAIGVFVYCL
LFNQQDFDQTSLQSGIIRAVSVLLISCPCAIGIAVPLVESQLLNAFAKLGVIIRNRACLALLGKETILVCDKTGTVTEGK
YTVLSGYEKLSLEEKSVLKALVSHSNHPIARSVDQAIIDFEESNIEKIEEIIGRGIRGYQGKIPYYFGSAIFLQQQGIST
PLIHLRKNMEAQTTVFFAKQNICLAAIHLGDRIQPEVQTLIQSLKGIKTLLLSGDSSLAVEAVARLCGFQEWFAEYHPLQ
KRELIEKLKKQGEIVMMIGDGINDAPALTASHIGVAVMSATDISIQVSDILLTTNRLQILQKMHHLAKKGHKIIKQNLFW
AFFYNCIGLGLAVYGSLTPLFAAFAMVMSSLLVLINSKRVYLNK
>Mature_764_residues
MHQILATQQALNNVSEHPLFKQALKSGLIANPRLLEEINSQKIGEKETLEKLHLEIHDMWCPSCAEVIKLTLLKEWGIAY
CYVDYTTDSATIEYAPVHITKERILKLISNLGYRPNFLQDPRQQVLSRTLSLRFVIAAFFSMNIMMFAYPIYVSFFNEQA
EGYAQLFAWLSLIGALPVLTYSAWPIWKRFYTGAKVGLWGMEALVVLGVAAATGLSIYEMWRGSSYVYFDSMTVIIVFVL
LGKMIESKAKFSAKDSLVQLTRALPRRGRKKISATKNEFVSLKEIHIGDLLVVLSGEKIVLDGIVEEGEGICNESLMTGE
ALPVPKNVGMDVLAGTILQQGSLVIKVTATSEQTALFQIVEMVEQDIGHKAQYVRTIDSIVKWFVPFVLCLAIGVFVYCL
LFNQQDFDQTSLQSGIIRAVSVLLISCPCAIGIAVPLVESQLLNAFAKLGVIIRNRACLALLGKETILVCDKTGTVTEGK
YTVLSGYEKLSLEEKSVLKALVSHSNHPIARSVDQAIIDFEESNIEKIEEIIGRGIRGYQGKIPYYFGSAIFLQQQGIST
PLIHLRKNMEAQTTVFFAKQNICLAAIHLGDRIQPEVQTLIQSLKGIKTLLLSGDSSLAVEAVARLCGFQEWFAEYHPLQ
KRELIEKLKKQGEIVMMIGDGINDAPALTASHIGVAVMSATDISIQVSDILLTTNRLQILQKMHHLAKKGHKIIKQNLFW
AFFYNCIGLGLAVYGSLTPLFAAFAMVMSSLLVLINSKRVYLNK

Specific function: Probably involved in copper import under copper limiting conditions [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=779, Percent_Identity=26.0590500641849, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI115529486, Length=529, Percent_Identity=26.8431001890359, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI55743073, Length=510, Percent_Identity=27.2549019607843, Blast_Score=176, Evalue=7e-44,
Organism=Escherichia coli, GI1786691, Length=745, Percent_Identity=26.5771812080537, Blast_Score=235, Evalue=8e-63,
Organism=Escherichia coli, GI1789879, Length=542, Percent_Identity=27.3062730627306, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI1786914, Length=478, Percent_Identity=24.6861924686192, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI2367363, Length=521, Percent_Identity=23.0326295585413, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=515, Percent_Identity=27.1844660194175, Blast_Score=159, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6320475, Length=762, Percent_Identity=26.6404199475066, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=593, Percent_Identity=26.8128161888702, Blast_Score=180, Evalue=9e-46,
Organism=Drosophila melanogaster, GI221329854, Length=527, Percent_Identity=26.9449715370019, Blast_Score=139, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 84973; Mature: 84973

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQILATQQALNNVSEHPLFKQALKSGLIANPRLLEEINSQKIGEKETLEKLHLEIHDMW
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHC
CPSCAEVIKLTLLKEWGIAYCYVDYTTDSATIEYAPVHITKERILKLISNLGYRPNFLQD
CHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEEEEEEECHHHHHHHHHHCCCCCCCCCC
PRQQVLSRTLSLRFVIAAFFSMNIMMFAYPIYVSFFNEQAEGYAQLFAWLSLIGALPVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAWPIWKRFYTGAKVGLWGMEALVVLGVAAATGLSIYEMWRGSSYVYFDSMTVIIVFVL
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEECCHHHHHHHHH
LGKMIESKAKFSAKDSLVQLTRALPRRGRKKISATKNEFVSLKEIHIGDLLVVLSGEKIV
HHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHEEEEECCEEEEEECCEEE
LDGIVEEGEGICNESLMTGEALPVPKNVGMDVLAGTILQQGSLVIKVTATSEQTALFQIV
EECHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
EMVEQDIGHKAQYVRTIDSIVKWFVPFVLCLAIGVFVYCLLFNQQDFDQTSLQSGIIRAV
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SVLLISCPCAIGIAVPLVESQLLNAFAKLGVIIRNRACLALLGKETILVCDKTGTVTEGK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCEEEEECCCCCCCCCC
YTVLSGYEKLSLEEKSVLKALVSHSNHPIARSVDQAIIDFEESNIEKIEEIIGRGIRGYQ
EEEECCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
GKIPYYFGSAIFLQQQGISTPLIHLRKNMEAQTTVFFAKQNICLAAIHLGDRIQPEVQTL
CCCCCEECCEEEEECCCCCCHHHHHHHCCCHHHEEEEEECCCEEEEEECCCCCCHHHHHH
IQSLKGIKTLLLSGDSSLAVEAVARLCGFQEWFAEYHPLQKRELIEKLKKQGEIVMMIGD
HHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECC
GINDAPALTASHIGVAVMSATDISIQVSDILLTTNRLQILQKMHHLAKKGHKIIKQNLFW
CCCCCCCHHHHHHCEEEEEECCCEEEEEHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFYNCIGLGLAVYGSLTPLFAAFAMVMSSLLVLINSKRVYLNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MHQILATQQALNNVSEHPLFKQALKSGLIANPRLLEEINSQKIGEKETLEKLHLEIHDMW
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHC
CPSCAEVIKLTLLKEWGIAYCYVDYTTDSATIEYAPVHITKERILKLISNLGYRPNFLQD
CHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEEEEEEECHHHHHHHHHHCCCCCCCCCC
PRQQVLSRTLSLRFVIAAFFSMNIMMFAYPIYVSFFNEQAEGYAQLFAWLSLIGALPVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAWPIWKRFYTGAKVGLWGMEALVVLGVAAATGLSIYEMWRGSSYVYFDSMTVIIVFVL
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEECCHHHHHHHHH
LGKMIESKAKFSAKDSLVQLTRALPRRGRKKISATKNEFVSLKEIHIGDLLVVLSGEKIV
HHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHEEEEECCEEEEEECCEEE
LDGIVEEGEGICNESLMTGEALPVPKNVGMDVLAGTILQQGSLVIKVTATSEQTALFQIV
EECHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
EMVEQDIGHKAQYVRTIDSIVKWFVPFVLCLAIGVFVYCLLFNQQDFDQTSLQSGIIRAV
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SVLLISCPCAIGIAVPLVESQLLNAFAKLGVIIRNRACLALLGKETILVCDKTGTVTEGK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCEEEEECCCCCCCCCC
YTVLSGYEKLSLEEKSVLKALVSHSNHPIARSVDQAIIDFEESNIEKIEEIIGRGIRGYQ
EEEECCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
GKIPYYFGSAIFLQQQGISTPLIHLRKNMEAQTTVFFAKQNICLAAIHLGDRIQPEVQTL
CCCCCEECCEEEEECCCCCCHHHHHHHCCCHHHEEEEEECCCEEEEEECCCCCCHHHHHH
IQSLKGIKTLLLSGDSSLAVEAVARLCGFQEWFAEYHPLQKRELIEKLKKQGEIVMMIGD
HHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECC
GINDAPALTASHIGVAVMSATDISIQVSDILLTTNRLQILQKMHHLAKKGHKIIKQNLFW
CCCCCCCHHHHHHCEEEEEECCCEEEEEHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFYNCIGLGLAVYGSLTPLFAAFAMVMSSLLVLINSKRVYLNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8048974; 7876197 [H]