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The map label for this gene is pgi

Identifier: 46446415

GI number: 46446415

Start: 963049

End: 964662

Strand: Direct

Name: pgi

Synonym: pc0781

Alternate gene names: 46446415

Gene position: 963049-964662 (Clockwise)

Preceding gene: 46446413

Following gene: 46446416

Centisome position: 39.89

GC content: 36.0

Gene sequence:

>1614_bases
TTGGAGTTTCGCATGTCAAAAACGTCCCCATCTCATTTTTTTAATTATTCTGCTAGTAAAAAGCTTCAAGAATTAGCTAA
GCATCCTCTTGATTTAACTAAAGAACTTACTCCAGAAAGAGTAACACAATATGTCGCGGAAGCTGGTGGATTTAAACTAC
TTTACGGAACAGAAAGAGTAACAAATGATGTTTTGGCCGCGTTAAAACAATTGTCTGAAGAATCTCATGCTTTAGATAAA
ATGAATCGCATGCAAGATGGGGAGGTAATGAATTTTATAGAGAGGTTTCCTTCAGAAAATCGACCGGCATTGCACACAGC
AACAAGAGATTTATTTGACTATCCTAGGACCGCTAAAAAAGCTCAAGAAGCGGCTCAATTGGCGAAAGCTGAGCTTGAAA
AACTTCGTCAATTTTTAGAAAAAAATGATCAGAATTATCATTTTACAGATCTTGTTACAGTTGCCATTGGAGGGTCTGAT
TTAGGGCCACGAGCTCATTATCATGCTCTGGAGCACCTTTTAAAACCCGGTCATCATGTTCATTTTATTTCCAATGTAGA
TCCTGATGATGTAGCAGGTGTTTTTAGAAAAATTCCTGATTTAAAGAGAACGCTTGTTGCTGTTGTTTCAAAATCTGGCA
CAACGCTTGAAACAGCAACTAATGAAGAATTGGTGCGCGAAAAATTTAGACAGGCGGGTCTAGATCCTAAAAAACATTTT
GTTTCAATCACAATGCCTGGAACACCAATGGATAACCAAGAACAATATCTCAAAACTTTTTATATGTGGGATTGGATAGG
AGGACGTTACTCAACAACTTCCATGTGCGGAGCTTTAATGTTATCTTTTGCCTTTGGAATCAATACCTTTTGGGAATTTC
TTAAAGGTGCGCATGAAATGGATAGAATTGCTTTAGAAACCAATTTGAATAAAAATTTACCTTTATTAGCTGCCCTTTTA
GGGATTTGGAATCGCAATTTTTTAGATTACCCTACTGTGGCTTTAATTCCCTACTCTCAAGCATTATTGCGATACACTGC
TCATATTCAACAAGTAGACATGGAATCTAATGGAAAGCATATTGATCAGCAAGGGATCATGACTAACTTTCACACTGGAC
CAATTATTTGGGGTGAACCCGGGACGAACTCGCAACATTCTTTCTTTCAATTAATTCATCAAGGAACAGCGACGGTTCCC
GTGAGTATTATTGCCTTCAAAGAAAATCTTTACGGAGAGGATCTAGAATTTCAAGGTACAACTTCTCAAGAAAAGTTATT
ATCAAATCTTTTTGCTCAAAGTCTTGCTTTAGCAACAGGGCAAATCTCAGAGAACCCAAACAAAACATTTTTAGGAAATA
GACCGACAAATATTTTATTGGCTAAAAAACTTACTCCTTATACTTTAGGGGCTCTCCTTTCTTTTTTTGAAAATAAAGTG
GCTTTTCAAGGATTTATTTGGGGAATTAATTCATTTGATCAAGAAGGGGTTCAATTAGGCAAAGTTTTAGCTAATCGTTT
AATAAATGAGTTTGCTAATCAAAGAAAAAAAACAAAACCTTCTTCTTTTGCAATTGGTGAAGCTTACTTGAAACATTTAG
ATCATTTTAGCTAA

Upstream 100 bases:

>100_bases
AGTTGCATAAAACATTAGAGAATTCTTCTTAGGCATAAAATGAAAAAAGCTTTCTCAATGAATGCTTAAGAAAAGTTAGA
TAGCAACCCCTTTTTCTTAT

Downstream 100 bases:

>100_bases
TATAGATCTAAATCTCGGGTTTATGGCTTGGGCATCATTTAAGTATTAAACTTATTGTTTTGTTTATGCGAGCTATGAGT
GAAAAATAAGTGGATGGAAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MEFRMSKTSPSHFFNYSASKKLQELAKHPLDLTKELTPERVTQYVAEAGGFKLLYGTERVTNDVLAALKQLSEESHALDK
MNRMQDGEVMNFIERFPSENRPALHTATRDLFDYPRTAKKAQEAAQLAKAELEKLRQFLEKNDQNYHFTDLVTVAIGGSD
LGPRAHYHALEHLLKPGHHVHFISNVDPDDVAGVFRKIPDLKRTLVAVVSKSGTTLETATNEELVREKFRQAGLDPKKHF
VSITMPGTPMDNQEQYLKTFYMWDWIGGRYSTTSMCGALMLSFAFGINTFWEFLKGAHEMDRIALETNLNKNLPLLAALL
GIWNRNFLDYPTVALIPYSQALLRYTAHIQQVDMESNGKHIDQQGIMTNFHTGPIIWGEPGTNSQHSFFQLIHQGTATVP
VSIIAFKENLYGEDLEFQGTTSQEKLLSNLFAQSLALATGQISENPNKTFLGNRPTNILLAKKLTPYTLGALLSFFENKV
AFQGFIWGINSFDQEGVQLGKVLANRLINEFANQRKKTKPSSFAIGEAYLKHLDHFS

Sequences:

>Translated_537_residues
MEFRMSKTSPSHFFNYSASKKLQELAKHPLDLTKELTPERVTQYVAEAGGFKLLYGTERVTNDVLAALKQLSEESHALDK
MNRMQDGEVMNFIERFPSENRPALHTATRDLFDYPRTAKKAQEAAQLAKAELEKLRQFLEKNDQNYHFTDLVTVAIGGSD
LGPRAHYHALEHLLKPGHHVHFISNVDPDDVAGVFRKIPDLKRTLVAVVSKSGTTLETATNEELVREKFRQAGLDPKKHF
VSITMPGTPMDNQEQYLKTFYMWDWIGGRYSTTSMCGALMLSFAFGINTFWEFLKGAHEMDRIALETNLNKNLPLLAALL
GIWNRNFLDYPTVALIPYSQALLRYTAHIQQVDMESNGKHIDQQGIMTNFHTGPIIWGEPGTNSQHSFFQLIHQGTATVP
VSIIAFKENLYGEDLEFQGTTSQEKLLSNLFAQSLALATGQISENPNKTFLGNRPTNILLAKKLTPYTLGALLSFFENKV
AFQGFIWGINSFDQEGVQLGKVLANRLINEFANQRKKTKPSSFAIGEAYLKHLDHFS
>Mature_537_residues
MEFRMSKTSPSHFFNYSASKKLQELAKHPLDLTKELTPERVTQYVAEAGGFKLLYGTERVTNDVLAALKQLSEESHALDK
MNRMQDGEVMNFIERFPSENRPALHTATRDLFDYPRTAKKAQEAAQLAKAELEKLRQFLEKNDQNYHFTDLVTVAIGGSD
LGPRAHYHALEHLLKPGHHVHFISNVDPDDVAGVFRKIPDLKRTLVAVVSKSGTTLETATNEELVREKFRQAGLDPKKHF
VSITMPGTPMDNQEQYLKTFYMWDWIGGRYSTTSMCGALMLSFAFGINTFWEFLKGAHEMDRIALETNLNKNLPLLAALL
GIWNRNFLDYPTVALIPYSQALLRYTAHIQQVDMESNGKHIDQQGIMTNFHTGPIIWGEPGTNSQHSFFQLIHQGTATVP
VSIIAFKENLYGEDLEFQGTTSQEKLLSNLFAQSLALATGQISENPNKTFLGNRPTNILLAKKLTPYTLGALLSFFENKV
AFQGFIWGINSFDQEGVQLGKVLANRLINEFANQRKKTKPSSFAIGEAYLKHLDHFS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=487, Percent_Identity=37.782340862423, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI296080693, Length=484, Percent_Identity=36.3636363636364, Blast_Score=275, Evalue=9e-74,
Organism=Escherichia coli, GI1790457, Length=552, Percent_Identity=37.6811594202899, Blast_Score=314, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71996708, Length=499, Percent_Identity=35.4709418837675, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71996703, Length=499, Percent_Identity=35.4709418837675, Blast_Score=277, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319673, Length=541, Percent_Identity=34.7504621072089, Blast_Score=279, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24651916, Length=495, Percent_Identity=37.3737373737374, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24651914, Length=495, Percent_Identity=37.3737373737374, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17737445, Length=495, Percent_Identity=37.3737373737374, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PARUW (Q6MD44)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007780.1
- ProteinModelPortal:   Q6MD44
- STRING:   Q6MD44
- GeneID:   2779784
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0781
- NMPDR:   fig|264201.1.peg.781
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- PhylomeDB:   Q6MD44
- ProtClustDB:   PRK14095
- BioCyc:   CPRO264201:PC0781-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60650; Mature: 60650

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 386-386 ACT_SITE 501-501

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRMSKTSPSHFFNYSASKKLQELAKHPLDLTKELTPERVTQYVAEAGGFKLLYGTERV
CCCCCCCCCCHHHHCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCEEEEECCHHH
TNDVLAALKQLSEESHALDKMNRMQDGEVMNFIERFPSENRPALHTATRDLFDYPRTAKK
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHH
AQEAAQLAKAELEKLRQFLEKNDQNYHFTDLVTVAIGGSDLGPRAHYHALEHLLKPGHHV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEE
HFISNVDPDDVAGVFRKIPDLKRTLVAVVSKSGTTLETATNEELVREKFRQAGLDPKKHF
EEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHCE
VSITMPGTPMDNQEQYLKTFYMWDWIGGRYSTTSMCGALMLSFAFGINTFWEFLKGAHEM
EEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DRIALETNLNKNLPLLAALLGIWNRNFLDYPTVALIPYSQALLRYTAHIQQVDMESNGKH
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCC
IDQQGIMTNFHTGPIIWGEPGTNSQHSFFQLIHQGTATVPVSIIAFKENLYGEDLEFQGT
CCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
TSQEKLLSNLFAQSLALATGQISENPNKTFLGNRPTNILLAKKLTPYTLGALLSFFENKV
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AFQGFIWGINSFDQEGVQLGKVLANRLINEFANQRKKTKPSSFAIGEAYLKHLDHFS
HHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEFRMSKTSPSHFFNYSASKKLQELAKHPLDLTKELTPERVTQYVAEAGGFKLLYGTERV
CCCCCCCCCCHHHHCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCEEEEECCHHH
TNDVLAALKQLSEESHALDKMNRMQDGEVMNFIERFPSENRPALHTATRDLFDYPRTAKK
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHH
AQEAAQLAKAELEKLRQFLEKNDQNYHFTDLVTVAIGGSDLGPRAHYHALEHLLKPGHHV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEE
HFISNVDPDDVAGVFRKIPDLKRTLVAVVSKSGTTLETATNEELVREKFRQAGLDPKKHF
EEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHCE
VSITMPGTPMDNQEQYLKTFYMWDWIGGRYSTTSMCGALMLSFAFGINTFWEFLKGAHEM
EEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DRIALETNLNKNLPLLAALLGIWNRNFLDYPTVALIPYSQALLRYTAHIQQVDMESNGKH
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCC
IDQQGIMTNFHTGPIIWGEPGTNSQHSFFQLIHQGTATVPVSIIAFKENLYGEDLEFQGT
CCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
TSQEKLLSNLFAQSLALATGQISENPNKTFLGNRPTNILLAKKLTPYTLGALLSFFENKV
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AFQGFIWGINSFDQEGVQLGKVLANRLINEFANQRKKTKPSSFAIGEAYLKHLDHFS
HHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA