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The map label for this gene is lysC [H]

Identifier: 46446399

GI number: 46446399

Start: 944785

End: 945585

Strand: Direct

Name: lysC [H]

Synonym: pc0765

Alternate gene names: 46446399

Gene position: 944785-945585 (Clockwise)

Preceding gene: 46446388

Following gene: 46446400

Centisome position: 39.13

GC content: 37.83

Gene sequence:

>801_bases
TTGTTCGATTCATATCACCCAAAATTTATGAAAACATTAGTTATGAAATTTGGTGGGGCCTCTGTAGCTTCTCCGGAGCA
TTTTGCTCGCATTGCTGATCTAATTATTGAACGTCAATGTGTTTTCCCACGTTTAGTGATTGTTGTCAGTGCTATGGGAC
AAACGACGAACGAATTGATTAAATTAGCTCATCAGGTGCACCCAAATCCTCCTCAGCGTGAATATGATATGTTAATTAGT
GCGGGAGAGCGAATTAGTATGACTCTACTTGCTATGATCCTTTGCCGTAAAGGTAAAGACGCAGTAAGTTTTACTGGAAG
TCAATCAGGAATTTTAACTTGTTCTCAACATACTAGTGCTCATATTATTGATGTACGTCCTCAAAGGCTGATTCAGACTT
TAGAACAAGGCAAAATTGTTATAGTGGCGGGCTTTCAAGGAGTTAGTCAAGATAAAGAGGTAACAACTCTTGGAAGAGGG
GGGTCTGATACATCAGCAGTAGCAATTGGAGTGGCTTTGAAAGCTGAAAAAATAGAGTTTTATAAAGATGTGTTAGGAAT
ATATAACAAAGATCCTAAAATGTATAGCGATGCCATCTGCTATCCAACTCTTAATTATCAAGAAGCTTTGACAATTGTCA
ACCAAGGGGCCAAAGTTTTACATGCGAGAGCTATTAAACTTGCAGAGAAAAATGGCATGCCTTTGCATGTACGTTCATTT
ATTTCGAGGCATGATCAAGGAACTTGGATTACGAGTGTTGATTGTAAAAAATCGATAAATCCAGTTTATGAAATCTCTTA
A

Upstream 100 bases:

>100_bases
GGAATTTGCTTTTTGACTCTGATAAGCTAAACTAATTAAAGATCAGAAATTAGGTTCAAGTGTTTTTTATCAAAAAATAG
AATACACGTAAGATTCCTCA

Downstream 100 bases:

>100_bases
CAATAACATGAAAAAACGCTCTAAACTTACTATTACTCCTCTTTTTGAATTTTCCGAAAATGATGAAATAATGAAAAATA
ATTATCGGGAAATTATTTTA

Product: aspartate kinase II precursor

Products: NA

Alternate protein names: Aspartate kinase; ASK [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MFDSYHPKFMKTLVMKFGGASVASPEHFARIADLIIERQCVFPRLVIVVSAMGQTTNELIKLAHQVHPNPPQREYDMLIS
AGERISMTLLAMILCRKGKDAVSFTGSQSGILTCSQHTSAHIIDVRPQRLIQTLEQGKIVIVAGFQGVSQDKEVTTLGRG
GSDTSAVAIGVALKAEKIEFYKDVLGIYNKDPKMYSDAICYPTLNYQEALTIVNQGAKVLHARAIKLAEKNGMPLHVRSF
ISRHDQGTWITSVDCKKSINPVYEIS

Sequences:

>Translated_266_residues
MFDSYHPKFMKTLVMKFGGASVASPEHFARIADLIIERQCVFPRLVIVVSAMGQTTNELIKLAHQVHPNPPQREYDMLIS
AGERISMTLLAMILCRKGKDAVSFTGSQSGILTCSQHTSAHIIDVRPQRLIQTLEQGKIVIVAGFQGVSQDKEVTTLGRG
GSDTSAVAIGVALKAEKIEFYKDVLGIYNKDPKMYSDAICYPTLNYQEALTIVNQGAKVLHARAIKLAEKNGMPLHVRSF
ISRHDQGTWITSVDCKKSINPVYEIS
>Mature_266_residues
MFDSYHPKFMKTLVMKFGGASVASPEHFARIADLIIERQCVFPRLVIVVSAMGQTTNELIKLAHQVHPNPPQREYDMLIS
AGERISMTLLAMILCRKGKDAVSFTGSQSGILTCSQHTSAHIIDVRPQRLIQTLEQGKIVIVAGFQGVSQDKEVTTLGRG
GSDTSAVAIGVALKAEKIEFYKDVLGIYNKDPKMYSDAICYPTLNYQEALTIVNQGAKVLHARAIKLAEKNGMPLHVRSF
ISRHDQGTWITSVDCKKSINPVYEIS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=285, Percent_Identity=28.4210526315789, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786183, Length=295, Percent_Identity=25.7627118644068, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790455, Length=304, Percent_Identity=27.9605263157895, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 29377; Mature: 29377

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSYHPKFMKTLVMKFGGASVASPEHFARIADLIIERQCVFPRLVIVVSAMGQTTNELI
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KLAHQVHPNPPQREYDMLISAGERISMTLLAMILCRKGKDAVSFTGSQSGILTCSQHTSA
HHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCE
HIIDVRPQRLIQTLEQGKIVIVAGFQGVSQDKEVTTLGRGGSDTSAVAIGVALKAEKIEF
EEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEHHHHHHHH
YKDVLGIYNKDPKMYSDAICYPTLNYQEALTIVNQGAKVLHARAIKLAEKNGMPLHVRSF
HHHHHHHCCCCCCHHHCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
ISRHDQGTWITSVDCKKSINPVYEIS
HHHCCCCCEEEECCCHHCCCCCEECC
>Mature Secondary Structure
MFDSYHPKFMKTLVMKFGGASVASPEHFARIADLIIERQCVFPRLVIVVSAMGQTTNELI
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KLAHQVHPNPPQREYDMLISAGERISMTLLAMILCRKGKDAVSFTGSQSGILTCSQHTSA
HHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCE
HIIDVRPQRLIQTLEQGKIVIVAGFQGVSQDKEVTTLGRGGSDTSAVAIGVALKAEKIEF
EEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEHHHHHHHH
YKDVLGIYNKDPKMYSDAICYPTLNYQEALTIVNQGAKVLHARAIKLAEKNGMPLHVRSF
HHHHHHHCCCCCCHHHCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
ISRHDQGTWITSVDCKKSINPVYEIS
HHHCCCCCEEEECCCHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972; 7910936 [H]