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The map label for this gene is thrS [H]

Identifier: 46446335

GI number: 46446335

Start: 853772

End: 855433

Strand: Direct

Name: thrS [H]

Synonym: pc0701

Alternate gene names: 46446335

Gene position: 853772-855433 (Clockwise)

Preceding gene: 46446331

Following gene: 46446336

Centisome position: 35.36

GC content: 35.02

Gene sequence:

>1662_bases
ATGGGGGGAGGAGAGACTTCATACGGGTTTTATTATGATTTCATTTTCCAACAAAAAGTCGATAATAACCTTGTTTCTCT
GATTGAAGTTCACTTAAAAACTTTAATTAAAGAAAATCATCCTATCCAAGCTTTAAGTATGATGCGTGAAAATGCGCAGG
CTTTATTTGACCATCATGATCAACCTTTTTTAGCTGAGTTAGCAGGAGAAAAAGAGGAAAATATTGTTGAAATATTACAA
TTCAAACAATTTTATGGACTCTGCTCTTTTCCACTTATTTCTTCGACAGAAGAAATTGGCGTGGTTAAACTCTTAGAGTT
GGACTTTCGACAGGAAGAGAGAGAAGGGGAAACTTTGGTTGTGACACGCTTGTTGGGTACTTCTTTTCCAGATAATCAAA
AACTCAAGCAATTTTTAAAGCTATACGATAGCTATCGAAAAAAGAAAGATCATCGACAATTAGGAAGTGATTTAAATTTA
TTTAGTTTTCCAGAGAAATTAACGGCGTTAGAATGTGTTTGGCATCCTAAGGGAAACCTTTTGTTGATGCTTTTAAAAGA
GTGGGTAACCAAAGAATTTTCTAAAATCGGGAAATGGGAACCTGTTAATACTCCTTATGTGGTTAATTCTCATTTTTTTA
AATTCAATGTGGATTATTTACCGACTGTTGAGATGGGAACAGAGGAATATGTTTTTAGTCCATCTCCTTTGATTCAGCAT
CATTATCTTTTTAAACGCAAAAAGAAAGATTCTAGTGACTTACCTATTCATTTTTTTGAATGGGCGAAAAAATATGTCCT
ATCAACTCATCCTTTAAAAGAAGGATTATTCAATGCCGTTGGTTGGAGTGGAGATTTTTCTACGATCTTTTCTTCAGATG
AACAACTTAACCAAGAATTCATTTCTTCCTTGCAATTCATTGAACAAATCATTAGAATCTTTGGTTTTGAAGCCCGTTGG
TGTCTTGTCACTTCGAGACAAAAAAGTTTTAAATTTAGGCAAGAAAAGGCTGCAATTGATCGGATTGAGAAAATCCTTTC
TCTTTGTACTTTATCTTATCCTTTGCAAGATGAACACTTCGAAAGTGATTGTTTAGAAGGACCCCGACTAGAACTCAGAG
TAGCTGATGAAATTGGTCGGGAATGGGTTATATCGGCGTTGACTCTTATTTCTATTCACTATTTGAAGAAAGATAAGACT
GAAAAGCAAGAAAACGAAATAACGATTCCATTTGTTATAGTAAGGCAAATATGGGAATCACTAGATCGTTTGATAGCTTT
ATTAATTGAACGCTTTGAAGGTAGCTTTCCTTTATGGTTAGCTCCTGAACAAGTAAGAATTTTAGCAGTTGGAGAGGGCA
GCCTCTCTTATGCAAGGCAAATTGAAACTCGCTGTCGTTCTCAAGGATTGAGAGTCGGAGTTGATTTTAAAAAATCGACT
AAGTTAGGCGAAAAAATACACTTGGCGGAAAAAGAAAAAGTTCCTTATCTCCTAATTATTGGAGAGCAAGAAATTAAGCG
AAATGCGATAACCTTCCGATCAGTTGAAAAGCCTGGAAAAAGCGAATCAATTAGATTAGAGGAATTTTTAGAACAAATAC
GCCAAAAATGTGTTTGTCCAACAGTGTTGGATAATAACTATGAAGAGGAGAGACTAGATTAG

Upstream 100 bases:

>100_bases
GCCTTTTCTTCATTCAAACAAATCTTTACGTATTCAACGCCGTTCGGTGGCAGAGCTCTTGGCTTCTGTTGTTTCTCAGC
TTTTTCCTGGAGTATACTTA

Downstream 100 bases:

>100_bases
CTTGAAAGTTAATAGAGAAATACGAGCTCCAAAAGTTCGAGTCATTGATCATTTAGGTGAACAAGTAGGGATTATTCCCT
TATATGAAGCCTTGGCAATG

Product: putative threonine-tRNA ligase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MGGGETSYGFYYDFIFQQKVDNNLVSLIEVHLKTLIKENHPIQALSMMRENAQALFDHHDQPFLAELAGEKEENIVEILQ
FKQFYGLCSFPLISSTEEIGVVKLLELDFRQEEREGETLVVTRLLGTSFPDNQKLKQFLKLYDSYRKKKDHRQLGSDLNL
FSFPEKLTALECVWHPKGNLLLMLLKEWVTKEFSKIGKWEPVNTPYVVNSHFFKFNVDYLPTVEMGTEEYVFSPSPLIQH
HYLFKRKKKDSSDLPIHFFEWAKKYVLSTHPLKEGLFNAVGWSGDFSTIFSSDEQLNQEFISSLQFIEQIIRIFGFEARW
CLVTSRQKSFKFRQEKAAIDRIEKILSLCTLSYPLQDEHFESDCLEGPRLELRVADEIGREWVISALTLISIHYLKKDKT
EKQENEITIPFVIVRQIWESLDRLIALLIERFEGSFPLWLAPEQVRILAVGEGSLSYARQIETRCRSQGLRVGVDFKKST
KLGEKIHLAEKEKVPYLLIIGEQEIKRNAITFRSVEKPGKSESIRLEEFLEQIRQKCVCPTVLDNNYEEERLD

Sequences:

>Translated_553_residues
MGGGETSYGFYYDFIFQQKVDNNLVSLIEVHLKTLIKENHPIQALSMMRENAQALFDHHDQPFLAELAGEKEENIVEILQ
FKQFYGLCSFPLISSTEEIGVVKLLELDFRQEEREGETLVVTRLLGTSFPDNQKLKQFLKLYDSYRKKKDHRQLGSDLNL
FSFPEKLTALECVWHPKGNLLLMLLKEWVTKEFSKIGKWEPVNTPYVVNSHFFKFNVDYLPTVEMGTEEYVFSPSPLIQH
HYLFKRKKKDSSDLPIHFFEWAKKYVLSTHPLKEGLFNAVGWSGDFSTIFSSDEQLNQEFISSLQFIEQIIRIFGFEARW
CLVTSRQKSFKFRQEKAAIDRIEKILSLCTLSYPLQDEHFESDCLEGPRLELRVADEIGREWVISALTLISIHYLKKDKT
EKQENEITIPFVIVRQIWESLDRLIALLIERFEGSFPLWLAPEQVRILAVGEGSLSYARQIETRCRSQGLRVGVDFKKST
KLGEKIHLAEKEKVPYLLIIGEQEIKRNAITFRSVEKPGKSESIRLEEFLEQIRQKCVCPTVLDNNYEEERLD
>Mature_552_residues
GGGETSYGFYYDFIFQQKVDNNLVSLIEVHLKTLIKENHPIQALSMMRENAQALFDHHDQPFLAELAGEKEENIVEILQF
KQFYGLCSFPLISSTEEIGVVKLLELDFRQEEREGETLVVTRLLGTSFPDNQKLKQFLKLYDSYRKKKDHRQLGSDLNLF
SFPEKLTALECVWHPKGNLLLMLLKEWVTKEFSKIGKWEPVNTPYVVNSHFFKFNVDYLPTVEMGTEEYVFSPSPLIQHH
YLFKRKKKDSSDLPIHFFEWAKKYVLSTHPLKEGLFNAVGWSGDFSTIFSSDEQLNQEFISSLQFIEQIIRIFGFEARWC
LVTSRQKSFKFRQEKAAIDRIEKILSLCTLSYPLQDEHFESDCLEGPRLELRVADEIGREWVISALTLISIHYLKKDKTE
KQENEITIPFVIVRQIWESLDRLIALLIERFEGSFPLWLAPEQVRILAVGEGSLSYARQIETRCRSQGLRVGVDFKKSTK
LGEKIHLAEKEKVPYLLIIGEQEIKRNAITFRSVEKPGKSESIRLEEFLEQIRQKCVCPTVLDNNYEEERLD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=535, Percent_Identity=25.981308411215, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI38202255, Length=543, Percent_Identity=24.6777163904236, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI20070344, Length=544, Percent_Identity=23.5294117647059, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1788013, Length=549, Percent_Identity=22.9508196721311, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71984184, Length=559, Percent_Identity=23.0769230769231, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71984192, Length=559, Percent_Identity=23.0769230769231, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322112, Length=561, Percent_Identity=24.4206773618538, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24583839, Length=535, Percent_Identity=23.7383177570093, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24583842, Length=535, Percent_Identity=23.7383177570093, Blast_Score=159, Evalue=7e-39,
Organism=Drosophila melanogaster, GI28574141, Length=535, Percent_Identity=23.7383177570093, Blast_Score=159, Evalue=7e-39,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 64577; Mature: 64446

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGETSYGFYYDFIFQQKVDNNLVSLIEVHLKTLIKENHPIQALSMMRENAQALFDHHD
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
QPFLAELAGEKEENIVEILQFKQFYGLCSFPLISSTEEIGVVKLLELDFRQEEREGETLV
CCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCEEE
VTRLLGTSFPDNQKLKQFLKLYDSYRKKKDHRQLGSDLNLFSFPEKLTALECVWHPKGNL
EEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEEECCCCCC
LLMLLKEWVTKEFSKIGKWEPVNTPYVVNSHFFKFNVDYLPTVEMGTEEYVFSPSPLIQH
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECEEEEEECCCCCCEECCCCCEEECCCHHHHH
HYLFKRKKKDSSDLPIHFFEWAKKYVLSTHPLKEGLFNAVGWSGDFSTIFSSDEQLNQEF
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
ISSLQFIEQIIRIFGFEARWCLVTSRQKSFKFRQEKAAIDRIEKILSLCTLSYPLQDEHF
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ESDCLEGPRLELRVADEIGREWVISALTLISIHYLKKDKTEKQENEITIPFVIVRQIWES
HHHHCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHCCCCCHHCCCEEHHHHHHHHHHHH
LDRLIALLIERFEGSFPLWLAPEQVRILAVGEGSLSYARQIETRCRSQGLRVGVDFKKST
HHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHH
KLGEKIHLAEKEKVPYLLIIGEQEIKRNAITFRSVEKPGKSESIRLEEFLEQIRQKCVCP
CCCCCEECCHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCC
TVLDNNYEEERLD
HHHCCCCHHHCCC
>Mature Secondary Structure 
GGGETSYGFYYDFIFQQKVDNNLVSLIEVHLKTLIKENHPIQALSMMRENAQALFDHHD
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
QPFLAELAGEKEENIVEILQFKQFYGLCSFPLISSTEEIGVVKLLELDFRQEEREGETLV
CCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCEEE
VTRLLGTSFPDNQKLKQFLKLYDSYRKKKDHRQLGSDLNLFSFPEKLTALECVWHPKGNL
EEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEEECCCCCC
LLMLLKEWVTKEFSKIGKWEPVNTPYVVNSHFFKFNVDYLPTVEMGTEEYVFSPSPLIQH
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECEEEEEECCCCCCEECCCCCEEECCCHHHHH
HYLFKRKKKDSSDLPIHFFEWAKKYVLSTHPLKEGLFNAVGWSGDFSTIFSSDEQLNQEF
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
ISSLQFIEQIIRIFGFEARWCLVTSRQKSFKFRQEKAAIDRIEKILSLCTLSYPLQDEHF
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ESDCLEGPRLELRVADEIGREWVISALTLISIHYLKKDKTEKQENEITIPFVIVRQIWES
HHHHCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHCCCCCHHCCCEEHHHHHHHHHHHH
LDRLIALLIERFEGSFPLWLAPEQVRILAVGEGSLSYARQIETRCRSQGLRVGVDFKKST
HHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHH
KLGEKIHLAEKEKVPYLLIIGEQEIKRNAITFRSVEKPGKSESIRLEEFLEQIRQKCVCP
CCCCCEECCHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCC
TVLDNNYEEERLD
HHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA