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The map label for this gene is uvrC

Identifier: 46446331

GI number: 46446331

Start: 848522

End: 850354

Strand: Direct

Name: uvrC

Synonym: pc0697

Alternate gene names: 46446331

Gene position: 848522-850354 (Clockwise)

Preceding gene: 46446330

Following gene: 46446335

Centisome position: 35.14

GC content: 37.92

Gene sequence:

>1833_bases
ATGTCCTACGATCCCAAAAAAATTGACCTCTTTCCGACCCTGCCTGGCGTTTATTTAATGAAAAATGAAGAGGGAGAAGT
TTTATATGTCGGAAAAGCTAAGAATTTACGTCAAAGAGTGAAACAATATTTTGTTCCCGGTCGAGATGGGCGACTCATGA
TTCCCTACTTAGTGGCTAAAATTAACTACATTGAAACGATTGTTGTCACATCGGAAAAAGAAGCCTTATTGCTTGAAAAT
AACCTTATTAAGCAGCATAAGCCTCGCTATAACGCTTTGTTAAAAGACGATAAAAGCTATATTGCTCTCAAAATTAGCCA
AAATGATGCATGGGCCACAGTTCGTTTAGTGCGTTACAAAGGTACACCGGAGCCAGATGGCCTTTATTTCGGCCCTTATA
CTAGTGCACAAGCAGCTCGCCAAACATTAGATCTGTTAAATAGATTATTTCCTCTTAGACAGTGCTCTGATCAAGAATTT
GCAAGGCGCACACGTCCTTGTTTACTCTATCAAATGAAGCGTTGTGTAGGCCCTTGTACACAAAAATGCACTAAAGGGGA
GTATCAACAACATCTTGATCGAACAATTAAGTTTCTAAGAGGACAAAATAAAGATGTTTTAAAAGATCTTTATGAAGAAA
TGCGTCTTTTATCAGAACAGTTAGAATTTGAAAAAGCCAACCATCTCTTACGAACCATTCGATATATTGAGAAAACAATT
GAAAGTCAATATGTAGATCGCCCTTTAGGACATGATGCTGATGCGATAGGCTTATTTCGTTATGGAGAGCATGTGGTTGT
GGTCCTCATGATATTTAGAGGAGGAAAACTTGTAGGATCTCGTCATTTTGAATTTGATAATATTATTGAAGAAGATCACG
AATTGTTAACTTCTTTTCTTCTACAACATTATGAAGGCGCAACTGAAATTCCTTCAGAGATTTTATTGCCAAGTAAAATT
TCTGATGAACATCCTGTGGAAGAAATTTTGTCGGCAAGGCGGGAGCAAAAAGTTAATTTACAAATTCCTCAAAGAGGAGA
AAAAAAAGCTTTAATTGAGATTGCTCAAAAAAACGCTGAGGCGTTATTTAAAACGCAAAAAGATGAAGCCACATTACGTG
AAAAAACATTATTAGAAATGCAAGAGTTGTTATTTCTCACCAATTATCCGACACGAATCGAGTGTTTTGATAATTCTAAT
ATTGCTGGATCAGAACCCGTTTCTTCGATGGTTGCTTTTACCGATGGGCTTAAAGACAGTAAAAGATATCGCACCTATCG
TTTAAAAATTGGTTCTAAGCCTGATGACTATGCGGCAATGTATGAAGTATTAACAAGGCGTTACAAGCGGGCAAAAGAAG
AAAACGACATGCCAGATTTAGTGGTCGTGGATGGGGGAAAGGGGCAATTAAACATTGCGATTAAAGTGTTTGAAGAACTT
AATATTACCGGAGTAGACCTCCTTGGGCTGGCGAAAGAAGCTGGTAGACACGATAAAGGGATGACGGCCGAACAAGTCTT
TACCTGTTACCAAAAAGAGCCAATTCTTTTGAAGGCAAATTCTCCTATTTTATTTCTCCTCCAAAAAATTCGAGACGAAG
CGCATCGCGTGGCCATTTCTTTTCACCGTAAAAGAAGATCAAAAAAAACACTCAAAAGTGCTTTAGACGATATCCCTGGT
ATTGGACCTGCCAAAAGAAAAACTTTATTAACACATTTTGGAAGTTTAAAAAAAATTGAATTAGCCGCTGATGCAGAACT
GCGTGAAGTAAAGGGAATTTCTGCCGCCAACATTGAAGCAATCCGCACATTCTTTCAAGGAAGAAAAGAGTGA

Upstream 100 bases:

>100_bases
AAATCCAAGAAAAATTAACTGAAAGTCTCAATTCTCTTCAAAGTAGTTTTCAACAACTCGTTCAACAAATTAGGCAACAA
CAATTTTAAGGCCTTTTTGA

Downstream 100 bases:

>100_bases
TTCATTAAAAGAGCGCGGTAAGCGTATTTATTTTAAATCCAATCTTTTTAAATAGATTTTTTAGCTGACTTTAGGCGTAT
TTGCATAAAAAAATCTCAAT

Product: putative excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAKINYIETIVVTSEKEALLLEN
NLIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYKGTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEF
ARRTRPCLLYQMKRCVGPCTQKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTI
ESQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFLLQHYEGATEIPSEILLPSKI
SDEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAEALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSN
IAGSEPVSSMVAFTDGLKDSKRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEEL
NITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAISFHRKRRSKKTLKSALDDIPG
IGPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEAIRTFFQGRKE

Sequences:

>Translated_610_residues
MSYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAKINYIETIVVTSEKEALLLEN
NLIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYKGTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEF
ARRTRPCLLYQMKRCVGPCTQKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTI
ESQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFLLQHYEGATEIPSEILLPSKI
SDEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAEALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSN
IAGSEPVSSMVAFTDGLKDSKRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEEL
NITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAISFHRKRRSKKTLKSALDDIPG
IGPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEAIRTFFQGRKE
>Mature_609_residues
SYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAKINYIETIVVTSEKEALLLENN
LIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYKGTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEFA
RRTRPCLLYQMKRCVGPCTQKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTIE
SQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFLLQHYEGATEIPSEILLPSKIS
DEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAEALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSNI
AGSEPVSSMVAFTDGLKDSKRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEELN
ITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAISFHRKRRSKKTLKSALDDIPGI
GPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEAIRTFFQGRKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=598, Percent_Identity=37.7926421404682, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788037, Length=214, Percent_Identity=28.5046728971963, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PARUW (Q6MDC8)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007696.1
- ProteinModelPortal:   Q6MDC8
- STRING:   Q6MDC8
- GeneID:   2781145
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0697
- NMPDR:   fig|264201.1.peg.697
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q6MDC8
- ProtClustDB:   CLSK2762231
- BioCyc:   CPRO264201:PC0697-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70105; Mature: 69974

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAK
CCCCCCEEEECCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEHHHHHHH
INYIETIVVTSEKEALLLENNLIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYK
HHHHEEEEEECCCCEEHHHHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCEEEEEEEEEC
GTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEFARRTRPCLLYQMKRCVGPCT
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCHHH
QKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTI
HHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFL
HHHHHCCCCCCCCCHHHHHHCCCHHEEHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHH
LQHYEGATEIPSEILLPSKISDEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAE
HHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHH
ALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSNIAGSEPVSSMVAFTDGLKDS
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCC
KRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEEL
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEHHC
NITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAIS
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
FHRKRRSKKTLKSALDDIPGIGPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHHH
IRTFFQGRKE
HHHHHCCCCC
>Mature Secondary Structure 
SYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAK
CCCCCEEEECCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEHHHHHHH
INYIETIVVTSEKEALLLENNLIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYK
HHHHEEEEEECCCCEEHHHHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCEEEEEEEEEC
GTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEFARRTRPCLLYQMKRCVGPCT
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCHHH
QKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTI
HHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFL
HHHHHCCCCCCCCCHHHHHHCCCHHEEHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHH
LQHYEGATEIPSEILLPSKISDEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAE
HHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHH
ALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSNIAGSEPVSSMVAFTDGLKDS
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCC
KRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEEL
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEHHC
NITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAIS
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
FHRKRRSKKTLKSALDDIPGIGPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHHH
IRTFFQGRKE
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA