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The map label for this gene is gmk

Identifier: 46446296

GI number: 46446296

Start: 806950

End: 807543

Strand: Direct

Name: gmk

Synonym: pc0662

Alternate gene names: 46446296

Gene position: 806950-807543 (Clockwise)

Preceding gene: 46446294

Following gene: 46446297

Centisome position: 33.42

GC content: 37.21

Gene sequence:

>594_bases
ATGTTGTTGGGTGGAAAAGACAAAAAAGGTTCTTTATTTATTGTAAGCGCTCCAGCCGGAACGGGGAAAACAACTCTGGT
AAATTTATTAGTTCAAGAATTTCCAACAGTGATTGCAAGTATTTCTTACACGACAAGAGCTCCTCGTTTAGGCGAAGTCA
ACGGAAAAGATTATTACTTTATCACAGAATCTGAATTTGAAGCAAAAATAGCTGCCGCTGATTTCCTCGAATATGTTAAA
CTTTATGATACTTATTATGGTACGTCACGAGAGTGGGTTGAAATTCAAAGGCAGCTAGGTTTGCATGTTATTTTAGTGAT
TGACACACAAGGGGCATTACAACTTCAAAAGCTGTGCGAGGCCACTTTTATCTTCATTCGACCACCTTCTTTGGATGAAT
TAAAAAATAGATTGATTAACCGCCAAACTGAATCGTTAGAGATGATAGAAAAGCGGCTGGCATGTGCAGAACGTGAATTG
GAAGCTGCTCAGTATTATGATTATGAAATTATCAATGATGATCTCCAAGAAGCCTATCAGGTATTAAGAAGCATTCTAAT
TGCTGAATACCATCGTATATCTAAGAAGCTTTAA

Upstream 100 bases:

>100_bases
GAAGCAAAATAATCCATGGCGAAGCATAGTTAGGTAAATTTTTTCAATCTATTTTCTTTTTGTAGATGTGCTAAAAAAAT
CCAAATTAGGTTTACTAACT

Downstream 100 bases:

>100_bases
GAGTTAAAATAAAGGAATTAAATAATGGAAAAAAAGATTCGATTTACCAATGAAAGTTTGTCTAAAAATTTCACAAGTAA
TTTTGAGTTGGTTAATTATG

Product: putative guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MLLGGKDKKGSLFIVSAPAGTGKTTLVNLLVQEFPTVIASISYTTRAPRLGEVNGKDYYFITESEFEAKIAAADFLEYVK
LYDTYYGTSREWVEIQRQLGLHVILVIDTQGALQLQKLCEATFIFIRPPSLDELKNRLINRQTESLEMIEKRLACAEREL
EAAQYYDYEIINDDLQEAYQVLRSILIAEYHRISKKL

Sequences:

>Translated_197_residues
MLLGGKDKKGSLFIVSAPAGTGKTTLVNLLVQEFPTVIASISYTTRAPRLGEVNGKDYYFITESEFEAKIAAADFLEYVK
LYDTYYGTSREWVEIQRQLGLHVILVIDTQGALQLQKLCEATFIFIRPPSLDELKNRLINRQTESLEMIEKRLACAEREL
EAAQYYDYEIINDDLQEAYQVLRSILIAEYHRISKKL
>Mature_197_residues
MLLGGKDKKGSLFIVSAPAGTGKTTLVNLLVQEFPTVIASISYTTRAPRLGEVNGKDYYFITESEFEAKIAAADFLEYVK
LYDTYYGTSREWVEIQRQLGLHVILVIDTQGALQLQKLCEATFIFIRPPSLDELKNRLINRQTESLEMIEKRLACAEREL
EAAQYYDYEIINDDLQEAYQVLRSILIAEYHRISKKL

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=37.9679144385027, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=37.9679144385027, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=37.9679144385027, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=34.4632768361582, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI186972120, Length=178, Percent_Identity=32.0224719101124, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI186700629, Length=178, Percent_Identity=32.0224719101124, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI186700627, Length=178, Percent_Identity=32.0224719101124, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118259, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI262118255, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI4505237, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI262118263, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI119943108, Length=171, Percent_Identity=30.9941520467836, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI261862237, Length=171, Percent_Identity=30.9941520467836, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI119943106, Length=171, Percent_Identity=30.9941520467836, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=44.5026178010471, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=35.978835978836, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=35.978835978836, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71988041, Length=132, Percent_Identity=31.8181818181818, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=181, Percent_Identity=43.0939226519337, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=39.5604395604396, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077626, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007136, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI85724806, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45554481, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45554489, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640542, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362232, Length=172, Percent_Identity=29.6511627906977, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281362230, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648808, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078485, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648810, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078487, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330166, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330164, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221330162, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_PARUW (Q6MDG3)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007661.1
- ProteinModelPortal:   Q6MDG3
- SMR:   Q6MDG3
- STRING:   Q6MDG3
- GeneID:   2780165
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0662
- NMPDR:   fig|264201.1.peg.662
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q6MDG3
- ProtClustDB:   CLSK2762214
- BioCyc:   CPRO264201:PC0662-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 22554; Mature: 22554

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLGGKDKKGSLFIVSAPAGTGKTTLVNLLVQEFPTVIASISYTTRAPRLGEVNGKDYYF
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
ITESEFEAKIAAADFLEYVKLYDTYYGTSREWVEIQRQLGLHVILVIDTQGALQLQKLCE
EECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHH
ATFIFIRPPSLDELKNRLINRQTESLEMIEKRLACAERELEAAQYYDYEIINDDLQEAYQ
HEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLRSILIAEYHRISKKL
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLGGKDKKGSLFIVSAPAGTGKTTLVNLLVQEFPTVIASISYTTRAPRLGEVNGKDYYF
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
ITESEFEAKIAAADFLEYVKLYDTYYGTSREWVEIQRQLGLHVILVIDTQGALQLQKLCE
EECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHH
ATFIFIRPPSLDELKNRLINRQTESLEMIEKRLACAERELEAAQYYDYEIINDDLQEAYQ
HEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLRSILIAEYHRISKKL
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA