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The map label for this gene is tyrP_3 [H]

Identifier: 46446223

GI number: 46446223

Start: 725868

End: 727151

Strand: Direct

Name: tyrP_3 [H]

Synonym: pc0589

Alternate gene names: 46446223

Gene position: 725868-727151 (Clockwise)

Preceding gene: 46446221

Following gene: 46446224

Centisome position: 30.06

GC content: 34.74

Gene sequence:

>1284_bases
GTGGAAGACAAGGAAACGAATCCTGAAAAAGGAAGTTTAATTTCTGCAATATTCTTAGTAGCAGGAACATGCATTGGTGG
AGGAATGTTAGCACTTCCTGTATCAACAGGAATAAGCGGATTTATTCCTTCAACAATCGTAATGGGATGCTGTTGGATTG
CGATGACTTTGTCAGCATTATTGTTATTAGAAGTGAATTTATGGATGAAGGAAGGCGCGCATGTGATTACTATGTCTTCC
ACCATTTTAGGTCCGGTAGGCCGTGTGATTAGTTGGATTCTCTTTTTATTTATCTCTTATGCTTCTATTGTGGCTTATAC
ATCTGCTGGAGGATCGTTGGTTAGAGATGTAGCCCCTTCTTTATTGGGAATGTCTATTTCGAAAGAATGGGGATGCTTAA
TTTTTATCGTTTGCTTTGGAGGAATTATTTACTTTGGAAGTCGTATTGTGGGAAAAGTAAATGCGATTTTTTTTGTTGCG
ATGATTGTGGCTTATTTAGCTTTAATCAGTACTGGATTGTCTGAAGTGAAATTAGAAATGCTTGGACATCGTCGTTGGTC
AACATCATTTTTAGCGATTCCTATTTTATTAACGACATTTAGTTTTCAAACAATGTTACCTAGTTTGACTCCTTATCTAA
AAAGGAATGCGATAGCATTACGTTGGGCTATTATTGGAGGAACAACTTTAACTTTTTTTGTTTATTTGATTTGGCAGTTT
TTAGTTCTTGGAGTCATTCCTCTTTTTGGACCAAATAGCCTTTTAAAAGCTTTAGAAGTAGGTGAACCTGTAACTCAATT
CGTTCGACAACATGTGCAAAGCTCTTGGGTTTCTAGTTTGGCCGAATATTTTGGATTTTTTGCTCTTGTTACTTCTTTTT
TAGGAATAGCTTTAGGTTTGTTCGATTTTTTGTCTGATGGTTTAAAAATAAAAAAGCAAGGGGTAGGAAAGATTGTTTTA
GGTTTATTGATCGTAATTCCCACATTTATTTTTTCTGCTTATTTTGAACGAATTTTCTTGCTTGCTTTAGATACTTCTGG
AGGGTTTGGTGATTCTATTTTAAATGGAATTATGCCTGTATTAATGGTTTGGATTGGCCGCTATTATCTTCATTTTCCCA
ATGAAAATCGCGTTCCTGGTGGAAAACCGTTACTTTTATTTGTCTTCGCTTTCTTTTTGACTTCACTGATTATTGAAATT
TTAATTCATACAGGATTTATTTGTTCCATTTTTGAAGCTTGTCAAATCATGTTAAATCAACAACAATACGGTATTAGCTT
TTAA

Upstream 100 bases:

>100_bases
AAGCAAAAGTTTAGCAAAAATTGAATGTTAAAAGAAGAATTAAAAGTTCAGATTAAAGTAATATCCATCACCAATCACTT
TGAAAATAATAGGAGCGCAA

Downstream 100 bases:

>100_bases
TAAAGGATGGTTATTTATGGGATTTGGTCTTGCTTTCAAAGCATTTATAAAAGCGTTTAAAGATCCTCAAAAAACAGAGG
AGTTTTTAAAAGACAACTCT

Product: putative aromatic amino acid-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEDKETNPEKGSLISAIFLVAGTCIGGGMLALPVSTGISGFIPSTIVMGCCWIAMTLSALLLLEVNLWMKEGAHVITMSS
TILGPVGRVISWILFLFISYASIVAYTSAGGSLVRDVAPSLLGMSISKEWGCLIFIVCFGGIIYFGSRIVGKVNAIFFVA
MIVAYLALISTGLSEVKLEMLGHRRWSTSFLAIPILLTTFSFQTMLPSLTPYLKRNAIALRWAIIGGTTLTFFVYLIWQF
LVLGVIPLFGPNSLLKALEVGEPVTQFVRQHVQSSWVSSLAEYFGFFALVTSFLGIALGLFDFLSDGLKIKKQGVGKIVL
GLLIVIPTFIFSAYFERIFLLALDTSGGFGDSILNGIMPVLMVWIGRYYLHFPNENRVPGGKPLLLFVFAFFLTSLIIEI
LIHTGFICSIFEACQIMLNQQQYGISF

Sequences:

>Translated_427_residues
MEDKETNPEKGSLISAIFLVAGTCIGGGMLALPVSTGISGFIPSTIVMGCCWIAMTLSALLLLEVNLWMKEGAHVITMSS
TILGPVGRVISWILFLFISYASIVAYTSAGGSLVRDVAPSLLGMSISKEWGCLIFIVCFGGIIYFGSRIVGKVNAIFFVA
MIVAYLALISTGLSEVKLEMLGHRRWSTSFLAIPILLTTFSFQTMLPSLTPYLKRNAIALRWAIIGGTTLTFFVYLIWQF
LVLGVIPLFGPNSLLKALEVGEPVTQFVRQHVQSSWVSSLAEYFGFFALVTSFLGIALGLFDFLSDGLKIKKQGVGKIVL
GLLIVIPTFIFSAYFERIFLLALDTSGGFGDSILNGIMPVLMVWIGRYYLHFPNENRVPGGKPLLLFVFAFFLTSLIIEI
LIHTGFICSIFEACQIMLNQQQYGISF
>Mature_427_residues
MEDKETNPEKGSLISAIFLVAGTCIGGGMLALPVSTGISGFIPSTIVMGCCWIAMTLSALLLLEVNLWMKEGAHVITMSS
TILGPVGRVISWILFLFISYASIVAYTSAGGSLVRDVAPSLLGMSISKEWGCLIFIVCFGGIIYFGSRIVGKVNAIFFVA
MIVAYLALISTGLSEVKLEMLGHRRWSTSFLAIPILLTTFSFQTMLPSLTPYLKRNAIALRWAIIGGTTLTFFVYLIWQF
LVLGVIPLFGPNSLLKALEVGEPVTQFVRQHVQSSWVSSLAEYFGFFALVTSFLGIALGLFDFLSDGLKIKKQGVGKIVL
GLLIVIPTFIFSAYFERIFLLALDTSGGFGDSILNGIMPVLMVWIGRYYLHFPNENRVPGGKPLLLFVFAFFLTSLIIEI
LIHTGFICSIFEACQIMLNQQQYGISF

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=405, Percent_Identity=31.6049382716049, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1790145, Length=386, Percent_Identity=25.9067357512953, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789552, Length=381, Percent_Identity=25.4593175853018, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46760; Mature: 46760

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKETNPEKGSLISAIFLVAGTCIGGGMLALPVSTGISGFIPSTIVMGCCWIAMTLSAL
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHH
LLLEVNLWMKEGAHVITMSSTILGPVGRVISWILFLFISYASIVAYTSAGGSLVRDVAPS
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLGMSISKEWGCLIFIVCFGGIIYFGSRIVGKVNAIFFVAMIVAYLALISTGLSEVKLEM
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LGHRRWSTSFLAIPILLTTFSFQTMLPSLTPYLKRNAIALRWAIIGGTTLTFFVYLIWQF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHH
LVLGVIPLFGPNSLLKALEVGEPVTQFVRQHVQSSWVSSLAEYFGFFALVTSFLGIALGL
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDFLSDGLKIKKQGVGKIVLGLLIVIPTFIFSAYFERIFLLALDTSGGFGDSILNGIMPV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
LMVWIGRYYLHFPNENRVPGGKPLLLFVFAFFLTSLIIEILIHTGFICSIFEACQIMLNQ
HHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QQYGISF
HHCCCCC
>Mature Secondary Structure
MEDKETNPEKGSLISAIFLVAGTCIGGGMLALPVSTGISGFIPSTIVMGCCWIAMTLSAL
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHH
LLLEVNLWMKEGAHVITMSSTILGPVGRVISWILFLFISYASIVAYTSAGGSLVRDVAPS
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLGMSISKEWGCLIFIVCFGGIIYFGSRIVGKVNAIFFVAMIVAYLALISTGLSEVKLEM
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LGHRRWSTSFLAIPILLTTFSFQTMLPSLTPYLKRNAIALRWAIIGGTTLTFFVYLIWQF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHH
LVLGVIPLFGPNSLLKALEVGEPVTQFVRQHVQSSWVSSLAEYFGFFALVTSFLGIALGL
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDFLSDGLKIKKQGVGKIVLGLLIVIPTFIFSAYFERIFLLALDTSGGFGDSILNGIMPV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
LMVWIGRYYLHFPNENRVPGGKPLLLFVFAFFLTSLIIEILIHTGFICSIFEACQIMLNQ
HHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QQYGISF
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]