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The map label for this gene is nuoL [H]

Identifier: 46446204

GI number: 46446204

Start: 702735

End: 704621

Strand: Direct

Name: nuoL [H]

Synonym: pc0570

Alternate gene names: 46446204

Gene position: 702735-704621 (Clockwise)

Preceding gene: 46446203

Following gene: 46446205

Centisome position: 29.11

GC content: 36.57

Gene sequence:

>1887_bases
ATGTGGCAAATGGTCGGACTCGGTCTTTTTTTACCTTTAATAGGTTTTTTGATTTTATTTACAAATTCTCAGCGACTCAG
TCGATCTACGACATCTTTTATCGGTTGCAGTACGATTTTATTAGCCTTTCTGATTTTTTTAGGAGAACTTTATTTTTATG
TTCATGCGGGAATGAATTCTCAAACATTTCCTTTATATCAATGGTTAACATTAAATGGGATCCAAGTGAATTTCAGTTGG
CACCTTGATTCACTTTCCTTATTAATGACCCTAATCATTACGGGAGTTGGATTTTTGATTCACCTATACTCTGTGGGTTA
TATGGATCATGAAAAGGATTTTACCCGCTATTTTGCTTGTTTGAATTTTTTTATTTTTGCAATGTTGCTACTCGTGTTAG
CGGGTGATTTATTAATGCTTTTTATTGGTTGGGAAGGTGTTGGACTGGCTTCTTATCTTTTGATTGGATTTTGGTATCAG
AAGCCATCTGCAGCAAAAGCAGCAACTAAGGCTTTTGTTGTGAATCGAATTGGAGATTTAGGTTTTTTATTAGGATTATT
ATTAACGCTTCATACATTTGGAACGACTGATATTGCTTCGATTTCACAATTAGCTAAGCAGACTTTTTCAATCGGAGCTC
CTATTATCACTGTCATGACTTTGCTTTATTTTTGGGGAGCGACAGGGAAGTCTGCACAATTGCCACTCTATCACTGGCTT
CCAGATGCGATGGAAGGCCCAACTCCTGTTTCTGCATTAATTCATGCTGCTACAATGGTAACAGCGGGAATTTATTTGAT
TGTTCGAACTCACACTTTGTTTGACTTATCTCCATTAACTCTGCATGTTGTTGGAATAGTAGGGGGAATGACAGCTCTTT
TTGCAGGGCTTTGTGCCTTAGCTCAAACAGATTTAAAACGAGTCCTCGCCTATTCGACAGTGAGCCAGCTTGGCTTAATG
TTTTTAGCTTGCGGGATTGGAGCTTACTATGCAGCAATGTTTCACTTGACTATTCACGCATTTGTGAAGGCACTTCTTTT
TCTTTCTGCCGGGAATGTTGTTCACATGATGTATGACACAACTGCATTAGAAAAGATGGGAGGATTATCAAAAATCTTCA
CTAAAACGCGATGGTTATTTTTAATAGGAGCTTTATCTTTAGCTGGAGTTTTTCCGTTTGCTGGATTCTTTAGTAAAGAT
CTTATCTTAGAATTGGGGTATTTATCGGGTTCTCATTTGCTTTTTAGTATGGGTTTAGTAGCTTCTCTTTTAACGGGTGT
GTACATGCTACGGGTTTATTGTTTAACATTTCACGGCGAACCCCGTTCTACTCAACAAGAACTTAGTCAAGTTCAAGAAG
CGCCCGCTATGATGGTAATTCCTGTGTCTATTTTAGGTTTACTCTCAATAGTTGGGGGATTTTTAGGTTTCAGGTTCTAC
TCTACTCCTGCTTTAATAAATTTTTTAGAGGAGATCGGAATTAGCTCTATAGAAAAAAATCTTAGTACCGGTCTTCACTT
ATCTGCGACAGGTTTAATAGCTATGTTAGGATCGATAATTGGTGTTATTATGACTGCATTTATTTACACACGCTATTATA
AAAGTCTTGGAAATTCTATTATTTTTTTGAAAAATTCTTTTTATGTCGAAAAGCTTTATCGAAGCTTAATTGTCAATCCC
TTAAGAATTTTAGCTTCTTTTATTGTAGGTAAAGTAGAAGCACATGCCATTAACGGCTCTCTTTTATTGGCAACAAATGT
TGTTCAAAAAACAGCTGGATTGTTACAGAAATTTCAAAATGGCCAAGTACGTTCATATATTGCTTGGATGGTAACAGGGG
CTGGTATATTGATTGTTTATTTTATTATTGAGGGATTCCATGCCTAA

Upstream 100 bases:

>100_bases
GCTGCAGCTGAAGCTGCTGTCGGCCTTGCTATTATCATTAATATGTTTAGATCAAAGCAAGTTGTTGACGTTGATCAATA
TAATTTGCTGAGGGGTTGAT

Downstream 100 bases:

>100_bases
TTTGTTTTGGTTATTTTTAATACCTTTTGTCTCTTCGATTTTAATAGGAATCCTGCCAATTAATGAGAAAAAACATTTAA
AATGGGCTTCATTGGGATTG

Product: putative NADH-ubiquinone oxidoreductase chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MWQMVGLGLFLPLIGFLILFTNSQRLSRSTTSFIGCSTILLAFLIFLGELYFYVHAGMNSQTFPLYQWLTLNGIQVNFSW
HLDSLSLLMTLIITGVGFLIHLYSVGYMDHEKDFTRYFACLNFFIFAMLLLVLAGDLLMLFIGWEGVGLASYLLIGFWYQ
KPSAAKAATKAFVVNRIGDLGFLLGLLLTLHTFGTTDIASISQLAKQTFSIGAPIITVMTLLYFWGATGKSAQLPLYHWL
PDAMEGPTPVSALIHAATMVTAGIYLIVRTHTLFDLSPLTLHVVGIVGGMTALFAGLCALAQTDLKRVLAYSTVSQLGLM
FLACGIGAYYAAMFHLTIHAFVKALLFLSAGNVVHMMYDTTALEKMGGLSKIFTKTRWLFLIGALSLAGVFPFAGFFSKD
LILELGYLSGSHLLFSMGLVASLLTGVYMLRVYCLTFHGEPRSTQQELSQVQEAPAMMVIPVSILGLLSIVGGFLGFRFY
STPALINFLEEIGISSIEKNLSTGLHLSATGLIAMLGSIIGVIMTAFIYTRYYKSLGNSIIFLKNSFYVEKLYRSLIVNP
LRILASFIVGKVEAHAINGSLLLATNVVQKTAGLLQKFQNGQVRSYIAWMVTGAGILIVYFIIEGFHA

Sequences:

>Translated_628_residues
MWQMVGLGLFLPLIGFLILFTNSQRLSRSTTSFIGCSTILLAFLIFLGELYFYVHAGMNSQTFPLYQWLTLNGIQVNFSW
HLDSLSLLMTLIITGVGFLIHLYSVGYMDHEKDFTRYFACLNFFIFAMLLLVLAGDLLMLFIGWEGVGLASYLLIGFWYQ
KPSAAKAATKAFVVNRIGDLGFLLGLLLTLHTFGTTDIASISQLAKQTFSIGAPIITVMTLLYFWGATGKSAQLPLYHWL
PDAMEGPTPVSALIHAATMVTAGIYLIVRTHTLFDLSPLTLHVVGIVGGMTALFAGLCALAQTDLKRVLAYSTVSQLGLM
FLACGIGAYYAAMFHLTIHAFVKALLFLSAGNVVHMMYDTTALEKMGGLSKIFTKTRWLFLIGALSLAGVFPFAGFFSKD
LILELGYLSGSHLLFSMGLVASLLTGVYMLRVYCLTFHGEPRSTQQELSQVQEAPAMMVIPVSILGLLSIVGGFLGFRFY
STPALINFLEEIGISSIEKNLSTGLHLSATGLIAMLGSIIGVIMTAFIYTRYYKSLGNSIIFLKNSFYVEKLYRSLIVNP
LRILASFIVGKVEAHAINGSLLLATNVVQKTAGLLQKFQNGQVRSYIAWMVTGAGILIVYFIIEGFHA
>Mature_628_residues
MWQMVGLGLFLPLIGFLILFTNSQRLSRSTTSFIGCSTILLAFLIFLGELYFYVHAGMNSQTFPLYQWLTLNGIQVNFSW
HLDSLSLLMTLIITGVGFLIHLYSVGYMDHEKDFTRYFACLNFFIFAMLLLVLAGDLLMLFIGWEGVGLASYLLIGFWYQ
KPSAAKAATKAFVVNRIGDLGFLLGLLLTLHTFGTTDIASISQLAKQTFSIGAPIITVMTLLYFWGATGKSAQLPLYHWL
PDAMEGPTPVSALIHAATMVTAGIYLIVRTHTLFDLSPLTLHVVGIVGGMTALFAGLCALAQTDLKRVLAYSTVSQLGLM
FLACGIGAYYAAMFHLTIHAFVKALLFLSAGNVVHMMYDTTALEKMGGLSKIFTKTRWLFLIGALSLAGVFPFAGFFSKD
LILELGYLSGSHLLFSMGLVASLLTGVYMLRVYCLTFHGEPRSTQQELSQVQEAPAMMVIPVSILGLLSIVGGFLGFRFY
STPALINFLEEIGISSIEKNLSTGLHLSATGLIAMLGSIIGVIMTAFIYTRYYKSLGNSIIFLKNSFYVEKLYRSLIVNP
LRILASFIVGKVEAHAINGSLLLATNVVQKTAGLLQKFQNGQVRSYIAWMVTGAGILIVYFIIEGFHA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=412, Percent_Identity=40.2912621359223, Blast_Score=280, Evalue=4e-75,
Organism=Escherichia coli, GI1788614, Length=627, Percent_Identity=40.1913875598086, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788829, Length=488, Percent_Identity=31.9672131147541, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=31.700288184438, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788827, Length=426, Percent_Identity=29.81220657277, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788613, Length=346, Percent_Identity=27.4566473988439, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI2367154, Length=424, Percent_Identity=23.8207547169811, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI145693160, Length=375, Percent_Identity=25.8666666666667, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68881; Mature: 68881

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWQMVGLGLFLPLIGFLILFTNSQRLSRSTTSFIGCSTILLAFLIFLGELYFYVHAGMNS
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QTFPLYQWLTLNGIQVNFSWHLDSLSLLMTLIITGVGFLIHLYSVGYMDHEKDFTRYFAC
CCCCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LNFFIFAMLLLVLAGDLLMLFIGWEGVGLASYLLIGFWYQKPSAAKAATKAFVVNRIGDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GFLLGLLLTLHTFGTTDIASISQLAKQTFSIGAPIITVMTLLYFWGATGKSAQLPLYHWL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHCC
PDAMEGPTPVSALIHAATMVTAGIYLIVRTHTLFDLSPLTLHVVGIVGGMTALFAGLCAL
CHHCCCCCHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AQTDLKRVLAYSTVSQLGLMFLACGIGAYYAAMFHLTIHAFVKALLFLSAGNVVHMMYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
TALEKMGGLSKIFTKTRWLFLIGALSLAGVFPFAGFFSKDLILELGYLSGSHLLFSMGLV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ASLLTGVYMLRVYCLTFHGEPRSTQQELSQVQEAPAMMVIPVSILGLLSIVGGFLGFRFY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHH
STPALINFLEEIGISSIEKNLSTGLHLSATGLIAMLGSIIGVIMTAFIYTRYYKSLGNSI
CHHHHHHHHHHHCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
IFLKNSFYVEKLYRSLIVNPLRILASFIVGKVEAHAINGSLLLATNVVQKTAGLLQKFQN
EEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEECCCEEEHHHHHHHHHHHHHHHCC
GQVRSYIAWMVTGAGILIVYFIIEGFHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWQMVGLGLFLPLIGFLILFTNSQRLSRSTTSFIGCSTILLAFLIFLGELYFYVHAGMNS
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QTFPLYQWLTLNGIQVNFSWHLDSLSLLMTLIITGVGFLIHLYSVGYMDHEKDFTRYFAC
CCCCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LNFFIFAMLLLVLAGDLLMLFIGWEGVGLASYLLIGFWYQKPSAAKAATKAFVVNRIGDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GFLLGLLLTLHTFGTTDIASISQLAKQTFSIGAPIITVMTLLYFWGATGKSAQLPLYHWL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHCC
PDAMEGPTPVSALIHAATMVTAGIYLIVRTHTLFDLSPLTLHVVGIVGGMTALFAGLCAL
CHHCCCCCHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AQTDLKRVLAYSTVSQLGLMFLACGIGAYYAAMFHLTIHAFVKALLFLSAGNVVHMMYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
TALEKMGGLSKIFTKTRWLFLIGALSLAGVFPFAGFFSKDLILELGYLSGSHLLFSMGLV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ASLLTGVYMLRVYCLTFHGEPRSTQQELSQVQEAPAMMVIPVSILGLLSIVGGFLGFRFY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHH
STPALINFLEEIGISSIEKNLSTGLHLSATGLIAMLGSIIGVIMTAFIYTRYYKSLGNSI
CHHHHHHHHHHHCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
IFLKNSFYVEKLYRSLIVNPLRILASFIVGKVEAHAINGSLLLATNVVQKTAGLLQKFQN
EEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEECCCEEEHHHHHHHHHHHHHHHCC
GQVRSYIAWMVTGAGILIVYFIIEGFHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA