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The map label for this gene is map [H]

Identifier: 46446180

GI number: 46446180

Start: 679625

End: 680521

Strand: Direct

Name: map [H]

Synonym: pc0546

Alternate gene names: 46446180

Gene position: 679625-680521 (Clockwise)

Preceding gene: 46446179

Following gene: 46446183

Centisome position: 28.15

GC content: 36.57

Gene sequence:

>897_bases
ATGCAGCAAATTTACAAGCAAAATTTTATTCGCGCAGGAGAATTAGCAAGTCAAGTTCGTGCGTATGGAAAAAGCCTTAT
AAAAAAAGGAGCTTCCTATAAAGACGTAATGGACAAAATTTCAGCGAAAATTTTTGAATTGGGAGCTAAACCTGCTTTTC
CTCCTCAAATGGCTTTAAATCATGTGGCGGCACATTATTTGATTTATCCGGGTGAAGACGTCATTTTCTCTGATCAAGTA
ATTAAACTTGATGTTGGTGTGTGTTATAAAGGAGCTATCGGTGATTGCGCAGTGACAGTTGATTTGTCGGATAAATATCA
AAAACTTATCCAAGCTGTAGAAGAAGCACTTTTGAATGCCGAACAAATAGTTAAGGTTGGATTACCTGTGCGGGAAATTG
GTTATACGATTGATCAAACCATTTCTTCTTATGGTTTTAAAGCTGTAAAAAATTTATCTGGGCATGGGTTAGGGCCTCAT
AAAATTCACACTTCGCCTATAATACCCAATTATGATAATCATTCTAAAGCGGTTGTTAAGCCAGGCATGACTTTTGCGAT
AGAACCTTTTGCAACAGATGGGGAAGGATTAATTTATGAAGAAGGAAAAGCGACTATATTTGCTTTTACTTCCTGGAGAC
CCGTTCGTTCCGAAATAGCTCGTTTAGTTCTAAATAAAGTAAAAACATTTAATGGTCTTCCTTTTTCTATTCACAATTTA
TTAGATGCACAATTCTCTCTATTAGAGGTGGAAACAGGACTGGCGGAACTATTACGATTTGGAGTGATTGCTGAATACGG
TCCATTGATTGAAGAAAAAAATGGAATTGTAGCTCAAGCTGAAAACTCTGTGCTAGTTGATGAACATGGAAAAGTTTTTA
TCACGACTCGTCTATAA

Upstream 100 bases:

>100_bases
ATTTTATTTTCAAATTTCCATTGAATTTAATTATCTTCTAATGATAGGAGACGGCATATTTGAATTTGTAAAAACCAGAA
ATTAGACAAGAAAATTAAGT

Downstream 100 bases:

>100_bases
ACTTGAAATTAGGATAATCGAAGGGCATTAATTCGTTAAGAGCATGTTCGATATTTGTTTGTTTCACTCTTTCTGCTTTT
CCTTGATCAATGAGCTGTTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQQIYKQNFIRAGELASQVRAYGKSLIKKGASYKDVMDKISAKIFELGAKPAFPPQMALNHVAAHYLIYPGEDVIFSDQV
IKLDVGVCYKGAIGDCAVTVDLSDKYQKLIQAVEEALLNAEQIVKVGLPVREIGYTIDQTISSYGFKAVKNLSGHGLGPH
KIHTSPIIPNYDNHSKAVVKPGMTFAIEPFATDGEGLIYEEGKATIFAFTSWRPVRSEIARLVLNKVKTFNGLPFSIHNL
LDAQFSLLEVETGLAELLRFGVIAEYGPLIEEKNGIVAQAENSVLVDEHGKVFITTRL

Sequences:

>Translated_298_residues
MQQIYKQNFIRAGELASQVRAYGKSLIKKGASYKDVMDKISAKIFELGAKPAFPPQMALNHVAAHYLIYPGEDVIFSDQV
IKLDVGVCYKGAIGDCAVTVDLSDKYQKLIQAVEEALLNAEQIVKVGLPVREIGYTIDQTISSYGFKAVKNLSGHGLGPH
KIHTSPIIPNYDNHSKAVVKPGMTFAIEPFATDGEGLIYEEGKATIFAFTSWRPVRSEIARLVLNKVKTFNGLPFSIHNL
LDAQFSLLEVETGLAELLRFGVIAEYGPLIEEKNGIVAQAENSVLVDEHGKVFITTRL
>Mature_298_residues
MQQIYKQNFIRAGELASQVRAYGKSLIKKGASYKDVMDKISAKIFELGAKPAFPPQMALNHVAAHYLIYPGEDVIFSDQV
IKLDVGVCYKGAIGDCAVTVDLSDKYQKLIQAVEEALLNAEQIVKVGLPVREIGYTIDQTISSYGFKAVKNLSGHGLGPH
KIHTSPIIPNYDNHSKAVVKPGMTFAIEPFATDGEGLIYEEGKATIFAFTSWRPVRSEIARLVLNKVKTFNGLPFSIHNL
LDAQFSLLEVETGLAELLRFGVIAEYGPLIEEKNGIVAQAENSVLVDEHGKVFITTRL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=308, Percent_Identity=26.9480519480519, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI164420681, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786364, Length=199, Percent_Identity=29.6482412060301, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17544396, Length=307, Percent_Identity=28.0130293159609, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71996291, Length=143, Percent_Identity=34.2657342657343, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319380, Length=318, Percent_Identity=27.9874213836478, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323273, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137568, Length=302, Percent_Identity=29.1390728476821, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21355531, Length=196, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583427, Length=194, Percent_Identity=26.2886597938144, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32753; Mature: 32753

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQIYKQNFIRAGELASQVRAYGKSLIKKGASYKDVMDKISAKIFELGAKPAFPPQMALN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HVAAHYLIYPGEDVIFSDQVIKLDVGVCYKGAIGDCAVTVDLSDKYQKLIQAVEEALLNA
HHHHHEEEECCCCEEECCCEEEEEECEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCH
EQIVKVGLPVREIGYTIDQTISSYGFKAVKNLSGHGLGPHKIHTSPIIPNYDNHSKAVVK
HHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCEEEC
PGMTFAIEPFATDGEGLIYEEGKATIFAFTSWRPVRSEIARLVLNKVKTFNGLPFSIHNL
CCCEEEEECCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LDAQFSLLEVETGLAELLRFGVIAEYGPLIEEKNGIVAQAENSVLVDEHGKVFITTRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEEEECC
>Mature Secondary Structure
MQQIYKQNFIRAGELASQVRAYGKSLIKKGASYKDVMDKISAKIFELGAKPAFPPQMALN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HVAAHYLIYPGEDVIFSDQVIKLDVGVCYKGAIGDCAVTVDLSDKYQKLIQAVEEALLNA
HHHHHEEEECCCCEEECCCEEEEEECEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCH
EQIVKVGLPVREIGYTIDQTISSYGFKAVKNLSGHGLGPHKIHTSPIIPNYDNHSKAVVK
HHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCEEEC
PGMTFAIEPFATDGEGLIYEEGKATIFAFTSWRPVRSEIARLVLNKVKTFNGLPFSIHNL
CCCEEEEECCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LDAQFSLLEVETGLAELLRFGVIAEYGPLIEEKNGIVAQAENSVLVDEHGKVFITTRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA