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The map label for this gene is lpxA [H]

Identifier: 46446037

GI number: 46446037

Start: 540487

End: 541335

Strand: Direct

Name: lpxA [H]

Synonym: pc0403

Alternate gene names: 46446037

Gene position: 540487-541335 (Clockwise)

Preceding gene: 46446036

Following gene: 46446038

Centisome position: 22.39

GC content: 38.63

Gene sequence:

>849_bases
ATGAAAAGTTCTTGTCAAATACACCCAACAGCTATTATTGCGCCTGGAGTGGTTATCGGAGAAAATGTCGTCATTGAACC
TTATGTTGTGATTGCTTCACCTCATGTGATTTTAGAAGATGATGTTGTTATTAAATCTCATACTTATATTGATGGTTACA
CAACCATTGGAGCAGGGACCATTATTTATCCGATGGCAAGTATCGGAACGAAAACACAAGATTTGAAATTTCAAGGTGAA
AGAACATTCGTCAAGATTGGTAAAAATTGTGAGATACGGGAATTTGTCACGATCAATTCATCTTGCCAAGAAGGATCAGT
AGTAGAAGTGGGGGACAATTGCCTCATTATGGCTTATTGCCACGTTGCCCATAATTGCGTCGTTGGAAATCGAGTGATTA
TGAGTAATAATGCTACATTAGCAGGACATGTAATTGTGGAAGATTATGCTGTGATTGGAGGTATGACTCCTATCCATCAG
TTTGTTCGAATTGGACGCAATGCAATGGTTGGAGGAATGAGTCGTGTGACTCATGATATCCCTCCATTTACAATTGGAGC
TGGAATTCCTTATAAATTTGGGGGATTAAATATTGTTGGATTGAAAAGACAGGGATATACTCTAGAAGTTCGGCAAGAAT
TGAGTAAAGCTTTTAAGCTTCTTTATCGTTCAGGTTTTCGTATGCAAGAAGCACTTAATCAAATTGAACAAGAATTAAAG
CCGCTTCCCGAAATTCAACATTTTGTCAACTTTTGTCGTTTGACAAAAAGGGGTTTAATGTGCCTTCAGGCGGAAGAAGA
GGGATTGAATTTGGAAGAACCCACTGAGCCTCTAAATGCAAGCAAGTAG

Upstream 100 bases:

>100_bases
ATTGCAGCCGAGGCTGAAATAGGCTTTGTGTTTGTAGACAAAAGTCAAATTTAATACACATCTCAAAAAATTAAAATATT
TTAAGTTAAGTGAATGTTGC

Downstream 100 bases:

>100_bases
TGAGAAATAGAAAAATGAAGGTTATTTTTTTTGGTACTCCTCTTTTTGCTGCGCAAGTTCTAGAATTCCTTTTGCAAAAT
CAGGTGGAAGTGGTCGCTGT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKSSCQIHPTAIIAPGVVIGENVVIEPYVVIASPHVILEDDVVIKSHTYIDGYTTIGAGTIIYPMASIGTKTQDLKFQGE
RTFVKIGKNCEIREFVTINSSCQEGSVVEVGDNCLIMAYCHVAHNCVVGNRVIMSNNATLAGHVIVEDYAVIGGMTPIHQ
FVRIGRNAMVGGMSRVTHDIPPFTIGAGIPYKFGGLNIVGLKRQGYTLEVRQELSKAFKLLYRSGFRMQEALNQIEQELK
PLPEIQHFVNFCRLTKRGLMCLQAEEEGLNLEEPTEPLNASK

Sequences:

>Translated_282_residues
MKSSCQIHPTAIIAPGVVIGENVVIEPYVVIASPHVILEDDVVIKSHTYIDGYTTIGAGTIIYPMASIGTKTQDLKFQGE
RTFVKIGKNCEIREFVTINSSCQEGSVVEVGDNCLIMAYCHVAHNCVVGNRVIMSNNATLAGHVIVEDYAVIGGMTPIHQ
FVRIGRNAMVGGMSRVTHDIPPFTIGAGIPYKFGGLNIVGLKRQGYTLEVRQELSKAFKLLYRSGFRMQEALNQIEQELK
PLPEIQHFVNFCRLTKRGLMCLQAEEEGLNLEEPTEPLNASK
>Mature_282_residues
MKSSCQIHPTAIIAPGVVIGENVVIEPYVVIASPHVILEDDVVIKSHTYIDGYTTIGAGTIIYPMASIGTKTQDLKFQGE
RTFVKIGKNCEIREFVTINSSCQEGSVVEVGDNCLIMAYCHVAHNCVVGNRVIMSNNATLAGHVIVEDYAVIGGMTPIHQ
FVRIGRNAMVGGMSRVTHDIPPFTIGAGIPYKFGGLNIVGLKRQGYTLEVRQELSKAFKLLYRSGFRMQEALNQIEQELK
PLPEIQHFVNFCRLTKRGLMCLQAEEEGLNLEEPTEPLNASK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=261, Percent_Identity=45.2107279693487, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1786376, Length=243, Percent_Identity=26.3374485596708, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 31019; Mature: 31019

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSCQIHPTAIIAPGVVIGENVVIEPYVVIASPHVILEDDVVIKSHTYIDGYTTIGAGT
CCCCCCCCCEEEEECCEEECCCEEECCEEEEECCEEEEECCEEEEEEEEECCEEECCCCE
IIYPMASIGTKTQDLKFQGERTFVKIGKNCEIREFVTINSSCQEGSVVEVGDNCLIMAYC
EEEEHHHCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEEH
HVAHNCVVGNRVIMSNNATLAGHVIVEDYAVIGGMTPIHQFVRIGRNAMVGGMSRVTHDI
HHHHCEEECCEEEEECCCEEEEEEEEECHHHHCCCHHHHHHHHHCCCHHHCCHHHHHHCC
PPFTIGAGIPYKFGGLNIVGLKRQGYTLEVRQELSKAFKLLYRSGFRMQEALNQIEQELK
CCEEECCCCCEEECCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
PLPEIQHFVNFCRLTKRGLMCLQAEEEGLNLEEPTEPLNASK
CCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSSCQIHPTAIIAPGVVIGENVVIEPYVVIASPHVILEDDVVIKSHTYIDGYTTIGAGT
CCCCCCCCCEEEEECCEEECCCEEECCEEEEECCEEEEECCEEEEEEEEECCEEECCCCE
IIYPMASIGTKTQDLKFQGERTFVKIGKNCEIREFVTINSSCQEGSVVEVGDNCLIMAYC
EEEEHHHCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEEH
HVAHNCVVGNRVIMSNNATLAGHVIVEDYAVIGGMTPIHQFVRIGRNAMVGGMSRVTHDI
HHHHCEEECCEEEEECCCEEEEEEEEECHHHHCCCHHHHHHHHHCCCHHHCCHHHHHHCC
PPFTIGAGIPYKFGGLNIVGLKRQGYTLEVRQELSKAFKLLYRSGFRMQEALNQIEQELK
CCEEECCCCCEEECCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
PLPEIQHFVNFCRLTKRGLMCLQAEEEGLNLEEPTEPLNASK
CCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA