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The map label for this gene is lpxD

Identifier: 45659285

GI number: 45659285

Start: 4243955

End: 4245070

Strand: Reverse

Name: lpxD

Synonym: LIC13469

Alternate gene names: 45659285

Gene position: 4245070-4243955 (Counterclockwise)

Preceding gene: 45659292

Following gene: 45659284

Centisome position: 99.25

GC content: 37.54

Gene sequence:

>1116_bases
ATGACGATCCAACTTGTTTGTTTCTCCGTGTATCCACAAAAATTAAACGAGGGAAATATGCCCCAAATTAAATTATCAGA
GCTAGCAAAAAAAATTAATGAATCTAAAATTGTAAATACTCAAATTCCGGACGAGGTGGTAGTAAATAAAATTGCCACTC
TGTCTCCGGGAGAGAAGAATTCTCTAAGTTTTCTTTCTCATAAGAAAATGTTAAGCGAAGCCAAAAAAACTCTTTCCAGT
GTGATACTAACCACCGAAGAATTTGCAAAAGAATTATCCATCCCTTGTATAGTAGTTTCCAATCCGGAGCTCAGCCTTGC
AGAAGTTTTAAATCTTCTTTATCCACCCTATGTTCCTGCGGGAAAAATATCTTCCTCAGCTATCATTCATCCTACTGCAA
AGTTGGGCGTCGGAGTAACCATTGGAGAATTTGTAGTAGTTGGAGAAAATTCTGTAATTGGTTCAAATACTTATTTGGAA
GACGGCGTTAAAATTTCTAGAAACGTAATCATCGGAGAAGATTCTCATATTGGTCCAAACTCTTCGATTCAACACGGAGT
TATCATTGGAAAAAGGTTTATCTGTTCCGGAAATTGTTCGATTGGCGGAGACGGTTTTAAATTTGTTACCGAAAAAGGTA
AACATCATAAGATTCCTCAAGTAGGTGGAGTAAGAATTGGAGACGATGTGGAAATCGGCTCCTTATGTACAATTGATCGT
GGTGGTTTGGAAGATACGATCATTGGAGACGGTTGCAAATTTGATAATATGGTTCACGTTGCACACAACTGCATACTCGG
AAAAAATATAATTATTGCAGGTCAAAGTGGTGTTGCAGGTAGTACTACCGTAGAAGACGATGTGATCATAGGCGGTGCAT
GTGCGGTTTCGGACCATCTTCATGTTCCTGCGGGAACAATTCTTGCCGGAGGAAGTTCCTTAAGAAATTCTCCTAAGAAA
AAAGAAATTTTTGTAGGTTGGGATTACGGTTTAACATTTGCTGAATTTCAAAAGGTTCGTGTCAATATTCATAATTTAGT
GAACTTTCAAAAGTGGGCCAAAAGAATCAAAGAATTGGAAAAACATGCTGGAATTAAAATTGAAGAAAAGGATTGA

Upstream 100 bases:

>100_bases
GAGAGCATTTCGTCAAACGGGATATTTAGAGTGTATTTACGGTAAAGTTGTAGTTCTTATAACTTGATAACTTTTCAAAG
AGATCATTATCTTTTTTTGA

Downstream 100 bases:

>100_bases
GCTTGACATTGCTTTAATTCGATAGACATTCTTTTCTTCACACACTTTTGGAGGATTCCCTTGTATTCCCGAGCAAACGA
AGATAACCCGGAAAATAAAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTIQLVCFSVYPQKLNEGNMPQIKLSELAKKINESKIVNTQIPDEVVVNKIATLSPGEKNSLSFLSHKKMLSEAKKTLSS
VILTTEEFAKELSIPCIVVSNPELSLAEVLNLLYPPYVPAGKISSSAIIHPTAKLGVGVTIGEFVVVGENSVIGSNTYLE
DGVKISRNVIIGEDSHIGPNSSIQHGVIIGKRFICSGNCSIGGDGFKFVTEKGKHHKIPQVGGVRIGDDVEIGSLCTIDR
GGLEDTIIGDGCKFDNMVHVAHNCILGKNIIIAGQSGVAGSTTVEDDVIIGGACAVSDHLHVPAGTILAGGSSLRNSPKK
KEIFVGWDYGLTFAEFQKVRVNIHNLVNFQKWAKRIKELEKHAGIKIEEKD

Sequences:

>Translated_371_residues
MTIQLVCFSVYPQKLNEGNMPQIKLSELAKKINESKIVNTQIPDEVVVNKIATLSPGEKNSLSFLSHKKMLSEAKKTLSS
VILTTEEFAKELSIPCIVVSNPELSLAEVLNLLYPPYVPAGKISSSAIIHPTAKLGVGVTIGEFVVVGENSVIGSNTYLE
DGVKISRNVIIGEDSHIGPNSSIQHGVIIGKRFICSGNCSIGGDGFKFVTEKGKHHKIPQVGGVRIGDDVEIGSLCTIDR
GGLEDTIIGDGCKFDNMVHVAHNCILGKNIIIAGQSGVAGSTTVEDDVIIGGACAVSDHLHVPAGTILAGGSSLRNSPKK
KEIFVGWDYGLTFAEFQKVRVNIHNLVNFQKWAKRIKELEKHAGIKIEEKD
>Mature_370_residues
TIQLVCFSVYPQKLNEGNMPQIKLSELAKKINESKIVNTQIPDEVVVNKIATLSPGEKNSLSFLSHKKMLSEAKKTLSSV
ILTTEEFAKELSIPCIVVSNPELSLAEVLNLLYPPYVPAGKISSSAIIHPTAKLGVGVTIGEFVVVGENSVIGSNTYLED
GVKISRNVIIGEDSHIGPNSSIQHGVIIGKRFICSGNCSIGGDGFKFVTEKGKHHKIPQVGGVRIGDDVEIGSLCTIDRG
GLEDTIIGDGCKFDNMVHVAHNCILGKNIIIAGQSGVAGSTTVEDDVIIGGACAVSDHLHVPAGTILAGGSSLRNSPKKK
EIFVGWDYGLTFAEFQKVRVNIHNLVNFQKWAKRIKELEKHAGIKIEEKD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=355, Percent_Identity=30.1408450704225, Blast_Score=168, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 39841; Mature: 39710

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00101 HEXAPEP_TRANSFERASES ; PS00268 CECROPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQLVCFSVYPQKLNEGNMPQIKLSELAKKINESKIVNTQIPDEVVVNKIATLSPGEKN
CEEEEEEEEECHHHCCCCCCCEEEHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCC
SLSFLSHKKMLSEAKKTLSSVILTTEEFAKELSIPCIVVSNPELSLAEVLNLLYPPYVPA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCC
GKISSSAIIHPTAKLGVGVTIGEFVVVGENSVIGSNTYLEDGVKISRNVIIGEDSHIGPN
CCCCCCEEECCHHHHCCCEEECCEEEECCCCEECCCCCCCCCCEEECEEEECCCCCCCCC
SSIQHGVIIGKRFICSGNCSIGGDGFKFVTEKGKHHKIPQVGGVRIGDDVEIGSLCTIDR
CCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEECC
GGLEDTIIGDGCKFDNMVHVAHNCILGKNIIIAGQSGVAGSTTVEDDVIIGGACAVSDHL
CCCCCEEECCCCCCCCCHHHHHHEEECCEEEEECCCCCCCCCCCCCCEEECCEEEECCCC
HVPAGTILAGGSSLRNSPKKKEIFVGWDYGLTFAEFQKVRVNIHNLVNFQKWAKRIKELE
CCCCCEEEECCHHHCCCCCCCEEEEEECCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHH
KHAGIKIEEKD
HHCCCEEECCC
>Mature Secondary Structure 
TIQLVCFSVYPQKLNEGNMPQIKLSELAKKINESKIVNTQIPDEVVVNKIATLSPGEKN
EEEEEEEEECHHHCCCCCCCEEEHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCC
SLSFLSHKKMLSEAKKTLSSVILTTEEFAKELSIPCIVVSNPELSLAEVLNLLYPPYVPA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCC
GKISSSAIIHPTAKLGVGVTIGEFVVVGENSVIGSNTYLEDGVKISRNVIIGEDSHIGPN
CCCCCCEEECCHHHHCCCEEECCEEEECCCCEECCCCCCCCCCEEECEEEECCCCCCCCC
SSIQHGVIIGKRFICSGNCSIGGDGFKFVTEKGKHHKIPQVGGVRIGDDVEIGSLCTIDR
CCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEECC
GGLEDTIIGDGCKFDNMVHVAHNCILGKNIIIAGQSGVAGSTTVEDDVIIGGACAVSDHL
CCCCCEEECCCCCCCCCHHHHHHEEECCEEEEECCCCCCCCCCCCCCEEECCEEEECCCC
HVPAGTILAGGSSLRNSPKKKEIFVGWDYGLTFAEFQKVRVNIHNLVNFQKWAKRIKELE
CCCCCEEEECCHHHCCCCCCCEEEEEECCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHH
KHAGIKIEEKD
HHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA