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The map label for this gene is 45659226

Identifier: 45659226

GI number: 45659226

Start: 4180311

End: 4181270

Strand: Reverse

Name: 45659226

Synonym: LIC13409

Alternate gene names: NA

Gene position: 4181270-4180311 (Counterclockwise)

Preceding gene: 45659228

Following gene: 45659225

Centisome position: 97.76

GC content: 31.04

Gene sequence:

>960_bases
ATGAACGAGAAAGTAAATTTCAAAAAAACAATTTTGGTAACCGGTGGTAGTGGTTCCTTGGGGTTGGTGCTTGTTCCTGA
ATTACTCAAAAGTTATAGAGTAATTTGTATTGGAAGAAAAATTTCTTCTTTTCCGGATACGATTCGATTTCATTCTAATT
TTATTTTTTACGAAGTGGATCTTGAAGACGATTCCGATTTTTCGATCCGAGAAAAGCCGGAATTTATTATTCATCTTGCG
GGAAAAGTCAGCGGCCAGGCTTTTACCTTGGAAGAATATAAAAAAGGGAATGAACTTTCAACTCGAAAGGTTCTTCAATT
TGCTTCTAAAAATCGTACGACTAAAATTTTATTTTCTAGCTCTTCTTCGGTTTATGGTTTTTCGGATCGACCCGTTACAG
AAACTTCTGCGTTAAACGGAAATACTTTTTATGCGATTTCAAAAATAGAATGTGAATTTCTCGTGAAGAAATCTAAAAAT
CCTTTTGTGATTTTAAGAATTGCTTCGGTTTACGGTCCTACTAATAAAAGTTTTCTAAATAAACTCTTAAAGTTGTTTCA
ATATGGGATTTTACTTTATTCTGGAAATCCTAATTTCAAAAAATCTGTTGTTCACTCTTGCGATGTTGTGGAGGCTATTT
TAATCGTATTAAAAAAATGGAATCAAGCTTCCGGAAAAATATTTAACGTCGCTTATCCTAAGGCTTTGAGTTTGGAAGAC
ATAGAATTTCTTTTTTCAAAATTAAATCCAAAGAAGTTTTTTCTTAAATTGAAACTTAAAGGTATAATATTATTTTTATT
GAATATAGTAAATATATTATTATCTAAATTGACTAAAAAGAAAATCAATTTAGAATACATTCAGGAGTCTTCGGTTATAG
ATTCTGGTCGAATCCAAAAAGAACTGGGTTTTCGGTTCAAAACGGATTTCGAAAAAGGGATTGGATCTATTTTAAAGTAA

Upstream 100 bases:

>100_bases
AGCACAACTATCGTTTTTGTTTTTACTCTGTCGAGAGTAAAAATCGAAACAACTTTTAAAAAATTCTTCTTTATACTTGT
AAAAGTATCACGGTGGTCTC

Downstream 100 bases:

>100_bases
TCAATTTGAATCATTCACAAAAATTACTACATCTCATCTCAAAAATACTTTATTTTTGCTTAAAATGCCAATCATTCTAA
GATTTTTTTGAAATAGCTTC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNEKVNFKKTILVTGGSGSLGLVLVPELLKSYRVICIGRKISSFPDTIRFHSNFIFYEVDLEDDSDFSIREKPEFIIHLA
GKVSGQAFTLEEYKKGNELSTRKVLQFASKNRTTKILFSSSSSVYGFSDRPVTETSALNGNTFYAISKIECEFLVKKSKN
PFVILRIASVYGPTNKSFLNKLLKLFQYGILLYSGNPNFKKSVVHSCDVVEAILIVLKKWNQASGKIFNVAYPKALSLED
IEFLFSKLNPKKFFLKLKLKGIILFLLNIVNILLSKLTKKKINLEYIQESSVIDSGRIQKELGFRFKTDFEKGIGSILK

Sequences:

>Translated_319_residues
MNEKVNFKKTILVTGGSGSLGLVLVPELLKSYRVICIGRKISSFPDTIRFHSNFIFYEVDLEDDSDFSIREKPEFIIHLA
GKVSGQAFTLEEYKKGNELSTRKVLQFASKNRTTKILFSSSSSVYGFSDRPVTETSALNGNTFYAISKIECEFLVKKSKN
PFVILRIASVYGPTNKSFLNKLLKLFQYGILLYSGNPNFKKSVVHSCDVVEAILIVLKKWNQASGKIFNVAYPKALSLED
IEFLFSKLNPKKFFLKLKLKGIILFLLNIVNILLSKLTKKKINLEYIQESSVIDSGRIQKELGFRFKTDFEKGIGSILK
>Mature_319_residues
MNEKVNFKKTILVTGGSGSLGLVLVPELLKSYRVICIGRKISSFPDTIRFHSNFIFYEVDLEDDSDFSIREKPEFIIHLA
GKVSGQAFTLEEYKKGNELSTRKVLQFASKNRTTKILFSSSSSVYGFSDRPVTETSALNGNTFYAISKIECEFLVKKSKN
PFVILRIASVYGPTNKSFLNKLLKLFQYGILLYSGNPNFKKSVVHSCDVVEAILIVLKKWNQASGKIFNVAYPKALSLED
IEFLFSKLNPKKFFLKLKLKGIILFLLNIVNILLSKLTKKKINLEYIQESSVIDSGRIQKELGFRFKTDFEKGIGSILK

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=248, Percent_Identity=28.2258064516129, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 36136; Mature: 36136

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKVNFKKTILVTGGSGSLGLVLVPELLKSYRVICIGRKISSFPDTIRFHSNFIFYEVD
CCCCCCEEEEEEEECCCCCEEEEEHHHHHHCCEEEEEECCCCCCCCCEEEECCEEEEEEE
LEDDSDFSIREKPEFIIHLAGKVSGQAFTLEEYKKGNELSTRKVLQFASKNRTTKILFSS
ECCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEC
SSSVYGFSDRPVTETSALNGNTFYAISKIECEFLVKKSKNPFVILRIASVYGPTNKSFLN
CCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHH
KLLKLFQYGILLYSGNPNFKKSVVHSCDVVEAILIVLKKWNQASGKIFNVAYPKALSLED
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
IEFLFSKLNPKKFFLKLKLKGIILFLLNIVNILLSKLTKKKINLEYIQESSVIDSGRIQK
HHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
ELGFRFKTDFEKGIGSILK
HHCCEEECCHHHHHHHHCC
>Mature Secondary Structure
MNEKVNFKKTILVTGGSGSLGLVLVPELLKSYRVICIGRKISSFPDTIRFHSNFIFYEVD
CCCCCCEEEEEEEECCCCCEEEEEHHHHHHCCEEEEEECCCCCCCCCEEEECCEEEEEEE
LEDDSDFSIREKPEFIIHLAGKVSGQAFTLEEYKKGNELSTRKVLQFASKNRTTKILFSS
ECCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEC
SSSVYGFSDRPVTETSALNGNTFYAISKIECEFLVKKSKNPFVILRIASVYGPTNKSFLN
CCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHH
KLLKLFQYGILLYSGNPNFKKSVVHSCDVVEAILIVLKKWNQASGKIFNVAYPKALSLED
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
IEFLFSKLNPKKFFLKLKLKGIILFLLNIVNILLSKLTKKKINLEYIQESSVIDSGRIQK
HHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
ELGFRFKTDFEKGIGSILK
HHCCEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]