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The map label for this gene is mtaP

Identifier: 45659216

GI number: 45659216

Start: 4167417

End: 4168280

Strand: Reverse

Name: mtaP

Synonym: LIC13399

Alternate gene names: 45659216

Gene position: 4168280-4167417 (Counterclockwise)

Preceding gene: 45659217

Following gene: 45659211

Centisome position: 97.45

GC content: 37.15

Gene sequence:

>864_bases
ATGTCGTATAACGTTAGAGTGGCTATCATTGGTGGAACTGGACTTTATAGCTTGGAAGGAATGGAATTAATCGAAGAAAT
TTTTCCTGACACTCCTTGGGGTAAACCTTCTGATAAAATTAAGATCGGTAAATACAAAGGAAAATTGATTGCGTTCTTAC
CTAGGCACGGAATTGGACATTTTCTTTCTCCACCTGAAGTCCCAAATCATGCAAATATATGCGCTCTAAAACAACTCGGC
GTTGAAGAAATTGTTGCATTTAGTTCGGTTGGAAGTTTGAGAGAAGAAATCAAACCTCTCGATTTTGTTTTACCGTCTCA
GATTATTGATCGTACTCGTTTTAGAAATTCTACTTATTTTGGAAATGGAGTTGTGGCACATGCTCCTTTCGCTGAACCTT
TTTCGCCTAACCTAAGTAAAAGAATCGCACAAACTGCTAAAAAAATCGGTTTAGAAATTCATTTGGATAAAACCTTGGTT
TGTATGGAAGGCCCTTTGTTTTCTACTAAGGCGGAGTCTCATCTTTATCGTTCTTGGGGTGCTGACATTATCAATATGAC
TGTTCTTCCGGAAGCAAAACTTGCTCGTGAAGCTGAAATTGCATATCAGATGATTTGTATGTCCACTGATTATGATTGTT
GGAGAGAAGGAGAAGAATCCGTCACGGTAGAAATGGTAATTGCAAATTTGACTAAAAATGCAGAGACAGCTAAAAAACTT
CTTTCTGAATTGATTCATGTACTTGGAAATGGAGATGATCTAAGTCTGAAAAATAGTACACGTTATTCGATCATTACAGC
TCCTGAAAAAAGAAACCCAGAGACGGTAAAAAAACTGAGAGTACTTTTTCCGGAATACTTTTAA

Upstream 100 bases:

>100_bases
AATTGTTTTCGTAAAAGCAGTTCCGATTTACATTTTGAGTACAATTTTTAAAACTGTCCCTGAATAAAATCTGAAAACTT
TCTCTTTAGGGAGTGGAATC

Downstream 100 bases:

>100_bases
TCTAAGTTTTAAAATTTCAAAAAACGAATTAATTCTATTGCGGTTCTATACAATAAATTTCTAATCTAATAATTACAAAA
CGACGATTTTATATAAAAAT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLG
VEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLV
CMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
LSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF

Sequences:

>Translated_287_residues
MSYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLG
VEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLV
CMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
LSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF
>Mature_286_residues
SYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGV
EEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVC
MEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLL
SELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA)

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family

Homologues:

Organism=Homo sapiens, GI47132622, Length=270, Percent_Identity=45.1851851851852, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71980569, Length=274, Percent_Identity=37.5912408759124, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323045, Length=307, Percent_Identity=47.8827361563518, Blast_Score=264, Evalue=1e-71,
Organism=Drosophila melanogaster, GI20130079, Length=253, Percent_Identity=38.7351778656126, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI221459247, Length=257, Percent_Identity=31.5175097276265, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNP_LEPIC (Q72LZ4)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_003302.1
- ProteinModelPortal:   Q72LZ4
- SMR:   Q72LZ4
- GeneID:   2771325
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC13399
- NMPDR:   fig|267671.1.peg.3302
- HOGENOM:   HBG286690
- OMA:   VVPDQFI
- ProtClustDB:   CLSK575197
- BioCyc:   LINT-130-01:LINT-130-01-003302-MONOMER
- BioCyc:   LINT267671:LIC_13399-MONOMER
- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099
- PANTHER:   PTHR11904
- TIGRFAMs:   TIGR01694

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =2.4.2.28

Molecular weight: Translated: 32069; Mature: 31938

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGH
CCCEEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCC
FLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYF
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCCCEE
GNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWG
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCHHHHHHHHHHC
ADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
CCEEEEEECCCHHHHHHHHHHHHHEEECCCCHHHHCCCCCEEEEEEEEHHHCCHHHHHHH
LSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF
HHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGH
CCEEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCC
FLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYF
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCCCEE
GNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWG
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCHHHHHHHHHHC
ADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
CCEEEEEECCCHHHHHHHHHHHHHEEECCCCHHHHCCCCCEEEEEEEEHHHCCHHHHHHH
LSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF
HHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA