| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is cysG
Identifier: 45659187
GI number: 45659187
Start: 4131267
End: 4131875
Strand: Reverse
Name: cysG
Synonym: LIC13368
Alternate gene names: 45659187
Gene position: 4131875-4131267 (Counterclockwise)
Preceding gene: 45659188
Following gene: 45659186
Centisome position: 96.6
GC content: 34.48
Gene sequence:
>609_bases ATGAGTCGTAAGTATCCGGCTTTTCTTAATTTAGAAAATAAGAATGTTCTGTTAATTGGTGGAGGAAAAGTCGCCTTAGA AAAGCTTCCTCATCTGATCGATTCCGGTGCAAAAATTACCTTGGTCACTTTAGAAACTTGTAAAGAAGTAGCACAAATTT TAGAAAAACATCCAGAAATTAAAGTAGAATATAGATCTGTAGAATTTACGGATCTTCAGGGAAGAGCCCTCGTTTTTTCC GCGACGAACGATACGGATTTAAATAGGAGACTCAGTGACTATGCCCATTCTTGGAAAATTTGGATTAATTGTTCCGACGA TCCAACTAACTGTGATTTTTATTCTGCTGCAGTTTTGGATAGAGGTCCGATTCGTGTTGCAATTTCTACGGAGGGAAATT TTGCAGGAATCTCCGGAGTTGTAAAAACTACTTTAGAGGAATTGATTCCCGATGAACACGAAGAAGAATTTAAAGAACTT ATGTTATTAAGAAAAGAATTAAAGTCTATTTTACCAAACCAAGAACGTAGAAGAAAAGTTCTTAAAGATTTGTTACAAAC TCTCAAAGATGATTATTTTAGAATTCCAATCGATTCAAAAAGAATATAA
Upstream 100 bases:
>100_bases GTTCGATTTTTGGAAAATAAGAAATTGACTTCGACCTTTTCTCAGTTTTCGAAAGAATCTTTTTTAGGGCAAATTTCTTC CGAGATCCAAGGAGGAAAGA
Downstream 100 bases:
>100_bases CGAAATTATAAACTCGAAAAAGGAAAAATCCAAACTATGTCAGAAGCAAAAGAACTATCACCCGTCGAAGATATAAAGTT AAACTCCAATAATCTAAGAG
Product: siroheme synthetase
Products: NA
Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]
Number of amino acids: Translated: 202; Mature: 201
Protein sequence:
>202_residues MSRKYPAFLNLENKNVLLIGGGKVALEKLPHLIDSGAKITLVTLETCKEVAQILEKHPEIKVEYRSVEFTDLQGRALVFS ATNDTDLNRRLSDYAHSWKIWINCSDDPTNCDFYSAAVLDRGPIRVAISTEGNFAGISGVVKTTLEELIPDEHEEEFKEL MLLRKELKSILPNQERRRKVLKDLLQTLKDDYFRIPIDSKRI
Sequences:
>Translated_202_residues MSRKYPAFLNLENKNVLLIGGGKVALEKLPHLIDSGAKITLVTLETCKEVAQILEKHPEIKVEYRSVEFTDLQGRALVFS ATNDTDLNRRLSDYAHSWKIWINCSDDPTNCDFYSAAVLDRGPIRVAISTEGNFAGISGVVKTTLEELIPDEHEEEFKEL MLLRKELKSILPNQERRRKVLKDLLQTLKDDYFRIPIDSKRI >Mature_201_residues SRKYPAFLNLENKNVLLIGGGKVALEKLPHLIDSGAKITLVTLETCKEVAQILEKHPEIKVEYRSVEFTDLQGRALVFSA TNDTDLNRRLSDYAHSWKIWINCSDDPTNCDFYSAAVLDRGPIRVAISTEGNFAGISGVVKTTLEELIPDEHEEEFKELM LLRKELKSILPNQERRRKVLKDLLQTLKDDYFRIPIDSKRI
Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si
COG id: COG1648
COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the precorrin methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1789768, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=1e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000878 - InterPro: IPR014777 - InterPro: IPR014776 - InterPro: IPR006366 - InterPro: IPR016040 - InterPro: IPR019478 - InterPro: IPR006367 - InterPro: IPR003043 [H]
Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]
EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]
Molecular weight: Translated: 23100; Mature: 22969
Theoretical pI: Translated: 6.53; Mature: 6.53
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.0 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 0.5 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRKYPAFLNLENKNVLLIGGGKVALEKLPHLIDSGAKITLVTLETCKEVAQILEKHPEI CCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCE KVEYRSVEFTDLQGRALVFSATNDTDLNRRLSDYAHSWKIWINCSDDPTNCDFYSAAVLD EEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCEEEHHEEC RGPIRVAISTEGNFAGISGVVKTTLEELIPDEHEEEFKELMLLRKELKSILPNQERRRKV CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH LKDLLQTLKDDYFRIPIDSKRI HHHHHHHHHCCEEECCCCCCCC >Mature Secondary Structure SRKYPAFLNLENKNVLLIGGGKVALEKLPHLIDSGAKITLVTLETCKEVAQILEKHPEI CCCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCE KVEYRSVEFTDLQGRALVFSATNDTDLNRRLSDYAHSWKIWINCSDDPTNCDFYSAAVLD EEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCEEEHHEEC RGPIRVAISTEGNFAGISGVVKTTLEELIPDEHEEEFKELMLLRKELKSILPNQERRRKV CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH LKDLLQTLKDDYFRIPIDSKRI HHHHHHHHHCCEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA