Click here to switch to the map view.

The map label for this gene is neuB

Identifier: 45658022

GI number: 45658022

Start: 2626541

End: 2627575

Strand: Reverse

Name: neuB

Synonym: LIC12173

Alternate gene names: NA

Gene position: 2627575-2626541 (Counterclockwise)

Preceding gene: 45658023

Following gene: 45658021

Centisome position: 61.43

GC content: 34.98

Gene sequence:

>1035_bases
ATGAGAAAATTATATCAAAATGAAAATTACAATATGAATACTTTAATTATTGCCGAAGCAGGGGTAAATCATAATGGAGA
TATGAATATCGCAGAGAAATTGATTAACGTTGCGTTTGATGCAGGCGTGGATATAGTAAAATTTCAGACGTTTCATGCAA
CCGAACTAGCCTCGAATTTTGCGAAAAAAGCTGATTATCAAATATCTAATATGCAAGAAGGTGGAACACAGGTTTCAATG
TTGAAAAAATTGGAACTTTCGGTTCAAGACCATTTTCGATTGATTGAAATTTGTAAAAAAAAGAATATTCAGTTTCTTTC
AACTGCTTTTGATTTAAAAAGTATCGACCTTTTAATCGAACTTGGTTTATCGTTATGGAAAATTCCAAGCGGTGAAATAA
CAAATTATCCTTATCTGAAAAAGATCGGTGAATTGAATCAGAAAATTATTCTTTCCACGGGAATGGCAAATTTAGGTGAG
ATTGAATCAGCATTGAATGTATTAATTAATTCCGGCTCATCCCTCGAAAATATTACGATTTTACATTGTACAACCGAGTA
TCCGGCTCCATTTCATGAAGTTAATCTTTATGCAATGGAAACTTTAAAATCTGCGTTCCGGGCAAAAGTAGGTTATTCTG
ATCACACTGTAGGAATCGAAGTTGCGATTGCAGCGGTTGCTCTTGGTGCTACAGTGATTGAAAAGCATTTTACACTAGAT
AAAAATTTACCAGGTCCCGATCATAAGGCTTCTCTTGAACCGAACGAGCTTAAAACGATGGTCTCCTCAATTCGTAATAT
AGAGAAATCTATGGGAGACGGAATTAAAAAACCAAGTAGCAGTGAAAGAAAGAACATCCCCATAGCAAGGAAATCAATTG
TAGCTACTCGTAATATTTCAAAAGGAGAAATTTTTTCCGAATCGAATATTACAACAAAAAGACCAGGAGATGGACTGTCT
CCTATGAATTGGGATATGGTAATCGGAAAGCAAGCTAGAAGAGATTTCCAGATCGATGAATTGATCGAGTTATGA

Upstream 100 bases:

>100_bases
TCTTTCATAGGGAGTGGGACTATTATTCGTGAGGGAGTTCATATCGGAAAAAAATGTCTCGTTGGTATGGGCTCCAAAAT
ATTGAAGAACATTTCTGATC

Downstream 100 bases:

>100_bases
AAAGGAAAATTTGTGTTATTACTGGCACTCGTGCTGACTACGGTCTGCTTCGTTGGTTGATTTTGGAAATTTCAAAATCT
TCTAAACTTGACTTACAAAT

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRKLYQNENYNMNTLIIAEAGVNHNGDMNIAEKLINVAFDAGVDIVKFQTFHATELASNFAKKADYQISNMQEGGTQVSM
LKKLELSVQDHFRLIEICKKKNIQFLSTAFDLKSIDLLIELGLSLWKIPSGEITNYPYLKKIGELNQKIILSTGMANLGE
IESALNVLINSGSSLENITILHCTTEYPAPFHEVNLYAMETLKSAFRAKVGYSDHTVGIEVAIAAVALGATVIEKHFTLD
KNLPGPDHKASLEPNELKTMVSSIRNIEKSMGDGIKKPSSSERKNIPIARKSIVATRNISKGEIFSESNITTKRPGDGLS
PMNWDMVIGKQARRDFQIDELIEL

Sequences:

>Translated_344_residues
MRKLYQNENYNMNTLIIAEAGVNHNGDMNIAEKLINVAFDAGVDIVKFQTFHATELASNFAKKADYQISNMQEGGTQVSM
LKKLELSVQDHFRLIEICKKKNIQFLSTAFDLKSIDLLIELGLSLWKIPSGEITNYPYLKKIGELNQKIILSTGMANLGE
IESALNVLINSGSSLENITILHCTTEYPAPFHEVNLYAMETLKSAFRAKVGYSDHTVGIEVAIAAVALGATVIEKHFTLD
KNLPGPDHKASLEPNELKTMVSSIRNIEKSMGDGIKKPSSSERKNIPIARKSIVATRNISKGEIFSESNITTKRPGDGLS
PMNWDMVIGKQARRDFQIDELIEL
>Mature_344_residues
MRKLYQNENYNMNTLIIAEAGVNHNGDMNIAEKLINVAFDAGVDIVKFQTFHATELASNFAKKADYQISNMQEGGTQVSM
LKKLELSVQDHFRLIEICKKKNIQFLSTAFDLKSIDLLIELGLSLWKIPSGEITNYPYLKKIGELNQKIILSTGMANLGE
IESALNVLINSGSSLENITILHCTTEYPAPFHEVNLYAMETLKSAFRAKVGYSDHTVGIEVAIAAVALGATVIEKHFTLD
KNLPGPDHKASLEPNELKTMVSSIRNIEKSMGDGIKKPSSSERKNIPIARKSIVATRNISKGEIFSESNITTKRPGDGLS
PMNWDMVIGKQARRDFQIDELIEL

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=336, Percent_Identity=32.7380952380952, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21357081, Length=355, Percent_Identity=32.6760563380282, Blast_Score=171, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 38200; Mature: 38200

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLYQNENYNMNTLIIAEAGVNHNGDMNIAEKLINVAFDAGVDIVKFQTFHATELASNF
CCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHH
AKKADYQISNMQEGGTQVSMLKKLELSVQDHFRLIEICKKKNIQFLSTAFDLKSIDLLIE
HHHCCCCHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
LGLSLWKIPSGEITNYPYLKKIGELNQKIILSTGMANLGEIESALNVLINSGSSLENITI
HCHHHEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEE
LHCTTEYPAPFHEVNLYAMETLKSAFRAKVGYSDHTVGIEVAIAAVALGATVIEKHFTLD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KNLPGPDHKASLEPNELKTMVSSIRNIEKSMGDGIKKPSSSERKNIPIARKSIVATRNIS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
KGEIFSESNITTKRPGDGLSPMNWDMVIGKQARRDFQIDELIEL
CCCEECCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCHHHHHCC
>Mature Secondary Structure
MRKLYQNENYNMNTLIIAEAGVNHNGDMNIAEKLINVAFDAGVDIVKFQTFHATELASNF
CCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHH
AKKADYQISNMQEGGTQVSMLKKLELSVQDHFRLIEICKKKNIQFLSTAFDLKSIDLLIE
HHHCCCCHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
LGLSLWKIPSGEITNYPYLKKIGELNQKIILSTGMANLGEIESALNVLINSGSSLENITI
HCHHHEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEE
LHCTTEYPAPFHEVNLYAMETLKSAFRAKVGYSDHTVGIEVAIAAVALGATVIEKHFTLD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KNLPGPDHKASLEPNELKTMVSSIRNIEKSMGDGIKKPSSSERKNIPIARKSIVATRNIS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
KGEIFSESNITTKRPGDGLSPMNWDMVIGKQARRDFQIDELIEL
CCCEECCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]