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The map label for this gene is creC [H]

Identifier: 45657758

GI number: 45657758

Start: 2292172

End: 2293497

Strand: Reverse

Name: creC [H]

Synonym: LIC11895

Alternate gene names: 45657758

Gene position: 2293497-2292172 (Counterclockwise)

Preceding gene: 45657759

Following gene: 45657757

Centisome position: 53.62

GC content: 34.31

Gene sequence:

>1326_bases
ATGGAAGCAGTGGAAGAATCGTTGAATGATACGGCTCATCTTTTGGCTTCTTTATTAGAAAGAGAATTTTCCCAAAAAAA
CGATTCTTTAGAAAAAATAAGCGAACGAATTCTTTCCCCAGTGATGCGGACTACAACGGAAAGAGATTTGAATTCTAAAA
TTTTTGAAATTACTAAAAAGAAAGTAGATCTGCAACTCTATGTTACAGATGAACGTGGAATCGTAATTTATGATTCGGAA
AAACTAAAAAAAGGACAGGACTATTCTAAAAAGAACGACGTATATCTCACCTTACAAGGAAAATATGGAGCCAGGTCTAG
TTTGTTATTTGGTTCCGAAAAAGGATTATTTGTAGCAGCCCCGATCCGAAAGTCTGGAAAAATAATCGGTGTACTTACGG
TGATCAAACCCAAAAAAAGTTTGATTCCTTTTATAGAATCCGCTCGAAAAAAATTTTGGAATTTAAGTTTGTATGTAGCT
CTTTCTATAATTATTTTGTTTATTAGTATTTTATATTTTTTGTTTTCACCGATTCGAAAATTATCTGAATATATTTCAGC
TTTGAGATTTCAAAAACGAGTTCCTTTCCCGAAAATCAGTGTACCCGAAATTAGAGGATTGGGGGAAGAGATGGACAGAT
TGTTTCGGGAACTTGCAGGAAAAGAATACGTGGAAAATTATGTACAATCCATGACTCACGAAATTAAAAGCCCACTTTCT
TCTCTACTTGCTTCTTCTGAGTTGATTATCGAAAATCCGGATCGTTTAGAATCTTTAGTTTCTAATATTCAATTAGAAGG
AAGAAGAATCCAAACAATTTTAGAAAAACTTTTAGAACTTAGTTCTTTAGAAAATCAATCTCAGTTGGAAAAAAAACTGA
ACCTCAATTTACAAGACGTGGTTCAAGAGACGGTTGCTTCTTCTATTTCGGAAGCGGTCCGAAAAAAAATACGTTTCAGA
GAGTTAACCGAAACCGTGTATGTGGAAGGGAATTTTTTCTTTTTAGGAATGGCTCTTAGAAATTTAGTTCAGAACGCATT
GGATTTTTCAAATCCAGGTTCAGAAATTACGGTTCGTTGTGGTAAAGAAAATGGATTTCCTTTTTTAGAAGTAGAAGATT
CTGGTCCTGGAATTCCATCTTATGCTTTGGAAAGAATTTTTGAGAAATTCTATTCTTTGCCTCGTCCTGATACTGGTCGT
AAAAGCTCTGGATTGGGGTTAGCATTTGTAAGAGAAATTGCAAAATTACACGATGCGGACTTGGAGGTAAAAAACGGAAC
TTCAACGGGTGTAATTGCTAGGATTTGTTTCAAAACAATTTTTTAA

Upstream 100 bases:

>100_bases
TGAGTCTTTTGATCCGAATTGTAATCGGTTTTTTTTTGCCTTCTTTATCGGTTATTATTACTTTGTAGATAAAATCGAAG
AATCGATTCGGCCACGTTAT

Downstream 100 bases:

>100_bases
TAAGAAAACAAGTTTTAACTAACGTGAGTTCAACGTAAAAAAACTGAGCGAATCCCATAACCAACCTTACAAGTATTTGG
ATCTCAATATAAATCTGTCG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MEAVEESLNDTAHLLASLLEREFSQKNDSLEKISERILSPVMRTTTERDLNSKIFEITKKKVDLQLYVTDERGIVIYDSE
KLKKGQDYSKKNDVYLTLQGKYGARSSLLFGSEKGLFVAAPIRKSGKIIGVLTVIKPKKSLIPFIESARKKFWNLSLYVA
LSIIILFISILYFLFSPIRKLSEYISALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSPLS
SLLASSELIIENPDRLESLVSNIQLEGRRIQTILEKLLELSSLENQSQLEKKLNLNLQDVVQETVASSISEAVRKKIRFR
ELTETVYVEGNFFFLGMALRNLVQNALDFSNPGSEITVRCGKENGFPFLEVEDSGPGIPSYALERIFEKFYSLPRPDTGR
KSSGLGLAFVREIAKLHDADLEVKNGTSTGVIARICFKTIF

Sequences:

>Translated_441_residues
MEAVEESLNDTAHLLASLLEREFSQKNDSLEKISERILSPVMRTTTERDLNSKIFEITKKKVDLQLYVTDERGIVIYDSE
KLKKGQDYSKKNDVYLTLQGKYGARSSLLFGSEKGLFVAAPIRKSGKIIGVLTVIKPKKSLIPFIESARKKFWNLSLYVA
LSIIILFISILYFLFSPIRKLSEYISALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSPLS
SLLASSELIIENPDRLESLVSNIQLEGRRIQTILEKLLELSSLENQSQLEKKLNLNLQDVVQETVASSISEAVRKKIRFR
ELTETVYVEGNFFFLGMALRNLVQNALDFSNPGSEITVRCGKENGFPFLEVEDSGPGIPSYALERIFEKFYSLPRPDTGR
KSSGLGLAFVREIAKLHDADLEVKNGTSTGVIARICFKTIF
>Mature_441_residues
MEAVEESLNDTAHLLASLLEREFSQKNDSLEKISERILSPVMRTTTERDLNSKIFEITKKKVDLQLYVTDERGIVIYDSE
KLKKGQDYSKKNDVYLTLQGKYGARSSLLFGSEKGLFVAAPIRKSGKIIGVLTVIKPKKSLIPFIESARKKFWNLSLYVA
LSIIILFISILYFLFSPIRKLSEYISALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSPLS
SLLASSELIIENPDRLESLVSNIQLEGRRIQTILEKLLELSSLENQSQLEKKLNLNLQDVVQETVASSISEAVRKKIRFR
ELTETVYVEGNFFFLGMALRNLVQNALDFSNPGSEITVRCGKENGFPFLEVEDSGPGIPSYALERIFEKFYSLPRPDTGR
KSSGLGLAFVREIAKLHDADLEVKNGTSTGVIARICFKTIF

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=450, Percent_Identity=34.4444444444444, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=30.4498269896194, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=31.3364055299539, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=274, Percent_Identity=28.1021897810219, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=25.4295532646048, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=293, Percent_Identity=25.938566552901, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994928, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=339, Percent_Identity=23.3038348082596, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=213, Percent_Identity=23.4741784037559, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=210, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50030; Mature: 50030

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVEESLNDTAHLLASLLEREFSQKNDSLEKISERILSPVMRTTTERDLNSKIFEITKK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVDLQLYVTDERGIVIYDSEKLKKGQDYSKKNDVYLTLQGKYGARSSLLFGSEKGLFVAA
HEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCEEEEC
PIRKSGKIIGVLTVIKPKKSLIPFIESARKKFWNLSLYVALSIIILFISILYFLFSPIRK
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEYISALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSPLS
HHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SLLASSELIIENPDRLESLVSNIQLEGRRIQTILEKLLELSSLENQSQLEKKLNLNLQDV
HHHCCCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
VQETVASSISEAVRKKIRFRELTETVYVEGNFFFLGMALRNLVQNALDFSNPGSEITVRC
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
GKENGFPFLEVEDSGPGIPSYALERIFEKFYSLPRPDTGRKSSGLGLAFVREIAKLHDAD
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
LEVKNGTSTGVIARICFKTIF
CEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEAVEESLNDTAHLLASLLEREFSQKNDSLEKISERILSPVMRTTTERDLNSKIFEITKK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVDLQLYVTDERGIVIYDSEKLKKGQDYSKKNDVYLTLQGKYGARSSLLFGSEKGLFVAA
HEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCEEEEC
PIRKSGKIIGVLTVIKPKKSLIPFIESARKKFWNLSLYVALSIIILFISILYFLFSPIRK
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEYISALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSPLS
HHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SLLASSELIIENPDRLESLVSNIQLEGRRIQTILEKLLELSSLENQSQLEKKLNLNLQDV
HHHCCCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
VQETVASSISEAVRKKIRFRELTETVYVEGNFFFLGMALRNLVQNALDFSNPGSEITVRC
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
GKENGFPFLEVEDSGPGIPSYALERIFEKFYSLPRPDTGRKSSGLGLAFVREIAKLHDAD
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
LEVKNGTSTGVIARICFKTIF
CEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]