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The map label for this gene is argH

Identifier: 45657703

GI number: 45657703

Start: 2235872

End: 2237284

Strand: Reverse

Name: argH

Synonym: LIC11840

Alternate gene names: 45657703

Gene position: 2237284-2235872 (Counterclockwise)

Preceding gene: 45657704

Following gene: 45657702

Centisome position: 52.31

GC content: 36.09

Gene sequence:

>1413_bases
ATGACTGAAAAAGAAAAAAAACTTTGGGGTGGAAGATTTCAAGAAAACGCATCTTCGATTTTAGAAAGGATCGGACAATC
CATATCCTTCGATCATAAACTTTATAAAGAGGATATTCAAGGAAGTATAGCTCATGCTAGGATGTTAAAACAGATCGGAA
TTTTAAATTCAGAAGAATTGTCTAAAATAGAAATCGCTCTCGCACAGATTAAAACCGAATTAGAAGAAGGAAAATTCGAA
TTCAAATCGGAACTAGAAGACATTCATATGCATATAGAGTTTCGTCTAACGGAATTAATAGGTGAAACCGGAAAAAAATT
ACATACTGCACGATCTAGAAATGATCAAGTTACTCAAGACGTAAGACTTTATATTTTAAATCAAGGAAAAGAAATTCTTA
AATCCATCATAAATCTTAGATCCTCTCTTTATCAAAAAGCAAAACAGAGTTTGGACGTAATTATACCCGGTTATACCCAT
TTACAAATAGCACAACCCATTCGCGCGTCCCAATATCTCCTTTCTTGGTTTTGGGCCTTGGAAAGAGATCAGGAATTTTT
TCGTTTTGCGTTTAAGGCTTCGGAGGAATTAGCTCTAGGTTCTGGAGCAATGGCGGGAGTTAACTATCCGACTGATAGGG
AATTTTTGAAAAAAGAATTAGGACTTTCTAAAGTATCCCCGAATTCTATGGACGGAGTTTCCAGTAGGGACCATATTTTA
GAATTCTTATTTGCATGTACTCAGTTAATGATCCACGTTTCTAGAATTTGTGAAGATATAATTCTTTATTCTTCTCAAGA
ATTTGGAATTTTAAAACTACCAGATTCCCTTACAACCGGTTCTTCTATCATGCCTCAGAAAAAAAATCCTGATATTGCAG
AACTCATTCGTGGAAAATCGGGAAGGGTAATTGGGAATTTAAATCATCTTTTAGTAATGCTAAAAGGTTTACCTTCCACA
TACAACCGAGATTTGCAAGAAGATAAATTAGCTCTGTTTGATTCGATCGAAACTGTTCAGATTAGTTTAGAGGGAATTCG
AGAGATGATTGAAGGTTGGATCTGGATTCCCGAAAGGGCAGAGGTTTCCCTAAAAAATGGATTTGCGACCGCGACGGATC
TCGCTGACTTTCTCGTAAACGAGAAGAAAATTCCTTTTCGAACGGCTCATGAACTCGTAGGAACTCTTGTTGGAGTTTGT
GTAAAACAAAAAAAGACATTGTTCGATTTACCTGAATCGGATCGAGTTTCGATTTCGAAATATTTTGTAGGAAAGGAATA
TGAGGATGCGGTCTCTCTCTCTCTTTCTGCGGATAAAAAAATTTCTTATGGAGGAACTTCTAAAAAAAGACAGGAAGAGC
AGTTAAAAATTGCGCTGGATTCTTTGAAGGAAGCAGAAAGATTGTTTTTATGA

Upstream 100 bases:

>100_bases
AAATCACCGAAGAAGAATTAGAAGTTTTGAAAAACTGGATTCAAAACCTGGAAGAAGAGTATCAGAAAGAGTAATCAAAA
ATAATCTGGTAAAGATCATC

Downstream 100 bases:

>100_bases
GAATTATTTTTGGAATATTAACGCTTGTTTGTTGTTTAACGTGTAATCGAAATCCATTTACTCAAACCAAATACCAACCG
GAAGTTTATACTATTTCTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTEKEKKLWGGRFQENASSILERIGQSISFDHKLYKEDIQGSIAHARMLKQIGILNSEELSKIEIALAQIKTELEEGKFE
FKSELEDIHMHIEFRLTELIGETGKKLHTARSRNDQVTQDVRLYILNQGKEILKSIINLRSSLYQKAKQSLDVIIPGYTH
LQIAQPIRASQYLLSWFWALERDQEFFRFAFKASEELALGSGAMAGVNYPTDREFLKKELGLSKVSPNSMDGVSSRDHIL
EFLFACTQLMIHVSRICEDIILYSSQEFGILKLPDSLTTGSSIMPQKKNPDIAELIRGKSGRVIGNLNHLLVMLKGLPST
YNRDLQEDKLALFDSIETVQISLEGIREMIEGWIWIPERAEVSLKNGFATATDLADFLVNEKKIPFRTAHELVGTLVGVC
VKQKKTLFDLPESDRVSISKYFVGKEYEDAVSLSLSADKKISYGGTSKKRQEEQLKIALDSLKEAERLFL

Sequences:

>Translated_470_residues
MTEKEKKLWGGRFQENASSILERIGQSISFDHKLYKEDIQGSIAHARMLKQIGILNSEELSKIEIALAQIKTELEEGKFE
FKSELEDIHMHIEFRLTELIGETGKKLHTARSRNDQVTQDVRLYILNQGKEILKSIINLRSSLYQKAKQSLDVIIPGYTH
LQIAQPIRASQYLLSWFWALERDQEFFRFAFKASEELALGSGAMAGVNYPTDREFLKKELGLSKVSPNSMDGVSSRDHIL
EFLFACTQLMIHVSRICEDIILYSSQEFGILKLPDSLTTGSSIMPQKKNPDIAELIRGKSGRVIGNLNHLLVMLKGLPST
YNRDLQEDKLALFDSIETVQISLEGIREMIEGWIWIPERAEVSLKNGFATATDLADFLVNEKKIPFRTAHELVGTLVGVC
VKQKKTLFDLPESDRVSISKYFVGKEYEDAVSLSLSADKKISYGGTSKKRQEEQLKIALDSLKEAERLFL
>Mature_469_residues
TEKEKKLWGGRFQENASSILERIGQSISFDHKLYKEDIQGSIAHARMLKQIGILNSEELSKIEIALAQIKTELEEGKFEF
KSELEDIHMHIEFRLTELIGETGKKLHTARSRNDQVTQDVRLYILNQGKEILKSIINLRSSLYQKAKQSLDVIIPGYTHL
QIAQPIRASQYLLSWFWALERDQEFFRFAFKASEELALGSGAMAGVNYPTDREFLKKELGLSKVSPNSMDGVSSRDHILE
FLFACTQLMIHVSRICEDIILYSSQEFGILKLPDSLTTGSSIMPQKKNPDIAELIRGKSGRVIGNLNHLLVMLKGLPSTY
NRDLQEDKLALFDSIETVQISLEGIREMIEGWIWIPERAEVSLKNGFATATDLADFLVNEKKIPFRTAHELVGTLVGVCV
KQKKTLFDLPESDRVSISKYFVGKEYEDAVSLSLSADKKISYGGTSKKRQEEQLKIALDSLKEAERLFL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=41.8300653594771, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=41.8300653594771, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=39.6514161220044, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=38.7799564270153, Blast_Score=288, Evalue=1e-77,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=40.2654867256637, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1787896, Length=339, Percent_Identity=24.188790560472, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17553882, Length=239, Percent_Identity=28.4518828451883, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=472, Percent_Identity=40.2542372881356, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6324993, Length=213, Percent_Identity=28.6384976525822, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221473854, Length=460, Percent_Identity=36.9565217391304, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI78706858, Length=460, Percent_Identity=36.9565217391304, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_LEPIC (Q72RA8)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001789.1
- ProteinModelPortal:   Q72RA8
- SMR:   Q72RA8
- GeneID:   2772690
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11840
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   LINT267671:LIC_11840-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 53353; Mature: 53222

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKEKKLWGGRFQENASSILERIGQSISFDHKLYKEDIQGSIAHARMLKQIGILNSEEL
CCCCHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SKIEIALAQIKTELEEGKFEFKSELEDIHMHIEFRLTELIGETGKKLHTARSRNDQVTQD
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VRLYILNQGKEILKSIINLRSSLYQKAKQSLDVIIPGYTHLQIAQPIRASQYLLSWFWAL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEHHHCHHHHHHHHHHHHHHH
ERDQEFFRFAFKASEELALGSGAMAGVNYPTDREFLKKELGLSKVSPNSMDGVSSRDHIL
HCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
EFLFACTQLMIHVSRICEDIILYSSQEFGILKLPDSLTTGSSIMPQKKNPDIAELIRGKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCC
GRVIGNLNHLLVMLKGLPSTYNRDLQEDKLALFDSIETVQISLEGIREMIEGWIWIPERA
CCEEECHHHHHHHHHCCCCHHCCCHHHHHHHHHCCHHHEEHHHHHHHHHHHCEEECCCCC
EVSLKNGFATATDLADFLVNEKKIPFRTAHELVGTLVGVCVKQKKTLFDLPESDRVSISK
CEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHH
YFVGKEYEDAVSLSLSADKKISYGGTSKKRQEEQLKIALDSLKEAERLFL
HCCCCCHHHHHEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKEKKLWGGRFQENASSILERIGQSISFDHKLYKEDIQGSIAHARMLKQIGILNSEEL
CCCHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SKIEIALAQIKTELEEGKFEFKSELEDIHMHIEFRLTELIGETGKKLHTARSRNDQVTQD
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VRLYILNQGKEILKSIINLRSSLYQKAKQSLDVIIPGYTHLQIAQPIRASQYLLSWFWAL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEHHHCHHHHHHHHHHHHHHH
ERDQEFFRFAFKASEELALGSGAMAGVNYPTDREFLKKELGLSKVSPNSMDGVSSRDHIL
HCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
EFLFACTQLMIHVSRICEDIILYSSQEFGILKLPDSLTTGSSIMPQKKNPDIAELIRGKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCC
GRVIGNLNHLLVMLKGLPSTYNRDLQEDKLALFDSIETVQISLEGIREMIEGWIWIPERA
CCEEECHHHHHHHHHCCCCHHCCCHHHHHHHHHCCHHHEEHHHHHHHHHHHCEEECCCCC
EVSLKNGFATATDLADFLVNEKKIPFRTAHELVGTLVGVCVKQKKTLFDLPESDRVSISK
CEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHH
YFVGKEYEDAVSLSLSADKKISYGGTSKKRQEEQLKIALDSLKEAERLFL
HCCCCCHHHHHEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA