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The map label for this gene is ppiB

Identifier: 45657702

GI number: 45657702

Start: 2235000

End: 2235875

Strand: Reverse

Name: ppiB

Synonym: LIC11839

Alternate gene names: 45657702

Gene position: 2235875-2235000 (Counterclockwise)

Preceding gene: 45657703

Following gene: 45657701

Centisome position: 52.27

GC content: 35.84

Gene sequence:

>876_bases
ATGAGAATTATTTTTGGAATATTAACGCTTGTTTGTTGTTTAACGTGTAATCGAAATCCATTTACTCAAACCAAATACCA
ACCGGAAGTTTATACTATTTCTTCCGTAGTGGTCCCAAAACCGGATACTGCAGTTGTTCCTTTGCCTGAAAAACCTGGTA
TCTACGCAATATTTTTGACTACTCAAGGAACGATGGTGCTTGAATTGTTCGATAAGGACGCTCCTAAAACAGTTCAGAAT
TTTATTGATCTTGCTCAGGGTGAAAAAGAATTTTTATCTAGAAACGGACAAAAAGTAAAAAAACCTTTTTATGACGGTTT
GACCTTTCATAGGGTGATTGAAAATTTTATGATTCAAGGAGGTTGTCCGAACGGAGACGGAACGGGGGGGCCAGGTTATC
GTTTTGAAGATGAAATCAACGGAAAATCACTTGGGCTTGATCAAGTAAAAGCGGGAGAATCTCCTTACTATCAATATCAA
TTGCAAAAAGTTGTAGCAAACGAACTTCAAATTAAAAATAGGGAAGAGGCAGAAACCAAAAGAGAATTGATTGAAAAAGC
GTTTGAAGACGCTAAAAAATTATCCGTTTTAGAAATTCTTTTTAGAACTGGATACAAATATAATGAAATTTTAAAGTCTC
ATAAAGCAGTTAAAGGATCTCTGGCAATGGCAAATGCCGGACCTAATACGAATGGTTCTCAATTTTTTATCAACCAAGTG
GATACACCTCATTTAGATGGGCTTCATACCGTTTTTGGACAACTTGTAACTGGAGAAGACGTAGTGGATAAAATCGTAAA
GACTGGTAACTCTAAAACTACGATTAAAAAGGTGCTTATCGTAGATAAAAGAAACGTAACTACAACTCCACAATGA

Upstream 100 bases:

>100_bases
CGGATAAAAAAATTTCTTATGGAGGAACTTCTAAAAAAAGACAGGAAGAGCAGTTAAAAATTGCGCTGGATTCTTTGAAG
GAAGCAGAAAGATTGTTTTT

Downstream 100 bases:

>100_bases
CTTTTGCAAAGGATAAAACTCAGGCAAAAAATTACTTAGCAGTGATTCATGAACTGGCAAATTATGTGTCTGGTTCTAGC
ACTGGTCGTATTTTAGAATG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MRIIFGILTLVCCLTCNRNPFTQTKYQPEVYTISSVVVPKPDTAVVPLPEKPGIYAIFLTTQGTMVLELFDKDAPKTVQN
FIDLAQGEKEFLSRNGQKVKKPFYDGLTFHRVIENFMIQGGCPNGDGTGGPGYRFEDEINGKSLGLDQVKAGESPYYQYQ
LQKVVANELQIKNREEAETKRELIEKAFEDAKKLSVLEILFRTGYKYNEILKSHKAVKGSLAMANAGPNTNGSQFFINQV
DTPHLDGLHTVFGQLVTGEDVVDKIVKTGNSKTTIKKVLIVDKRNVTTTPQ

Sequences:

>Translated_291_residues
MRIIFGILTLVCCLTCNRNPFTQTKYQPEVYTISSVVVPKPDTAVVPLPEKPGIYAIFLTTQGTMVLELFDKDAPKTVQN
FIDLAQGEKEFLSRNGQKVKKPFYDGLTFHRVIENFMIQGGCPNGDGTGGPGYRFEDEINGKSLGLDQVKAGESPYYQYQ
LQKVVANELQIKNREEAETKRELIEKAFEDAKKLSVLEILFRTGYKYNEILKSHKAVKGSLAMANAGPNTNGSQFFINQV
DTPHLDGLHTVFGQLVTGEDVVDKIVKTGNSKTTIKKVLIVDKRNVTTTPQ
>Mature_291_residues
MRIIFGILTLVCCLTCNRNPFTQTKYQPEVYTISSVVVPKPDTAVVPLPEKPGIYAIFLTTQGTMVLELFDKDAPKTVQN
FIDLAQGEKEFLSRNGQKVKKPFYDGLTFHRVIENFMIQGGCPNGDGTGGPGYRFEDEINGKSLGLDQVKAGESPYYQYQ
LQKVVANELQIKNREEAETKRELIEKAFEDAKKLSVLEILFRTGYKYNEILKSHKAVKGSLAMANAGPNTNGSQFFINQV
DTPHLDGLHTVFGQLVTGEDVVDKIVKTGNSKTTIKKVLIVDKRNVTTTPQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031987, Length=65, Percent_Identity=58.4615384615385, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7706339, Length=94, Percent_Identity=41.4893617021277, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI14277126, Length=82, Percent_Identity=41.4634146341463, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17565860, Length=65, Percent_Identity=63.0769230769231, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=76, Percent_Identity=51.3157894736842, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=89, Percent_Identity=43.8202247191011, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=63, Percent_Identity=52.3809523809524, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=63, Percent_Identity=52.3809523809524, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=76, Percent_Identity=48.6842105263158, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=90, Percent_Identity=44.4444444444444, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=58, Percent_Identity=60.3448275862069, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=80, Percent_Identity=50, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=76, Percent_Identity=50, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=74, Percent_Identity=51.3513513513513, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=76, Percent_Identity=46.0526315789474, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323246, Length=42, Percent_Identity=66.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=277, Percent_Identity=28.158844765343, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45549139, Length=65, Percent_Identity=55.3846153846154, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32429; Mature: 32429

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFGILTLVCCLTCNRNPFTQTKYQPEVYTISSVVVPKPDTAVVPLPEKPGIYAIFLT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCEEEEEEE
TQGTMVLELFDKDAPKTVQNFIDLAQGEKEFLSRNGQKVKKPFYDGLTFHRVIENFMIQG
CCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCC
GCPNGDGTGGPGYRFEDEINGKSLGLDQVKAGESPYYQYQLQKVVANELQIKNREEAETK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
RELIEKAFEDAKKLSVLEILFRTGYKYNEILKSHKAVKGSLAMANAGPNTNGSQFFINQV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECC
DTPHLDGLHTVFGQLVTGEDVVDKIVKTGNSKTTIKKVLIVDKRNVTTTPQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MRIIFGILTLVCCLTCNRNPFTQTKYQPEVYTISSVVVPKPDTAVVPLPEKPGIYAIFLT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCEEEEEEE
TQGTMVLELFDKDAPKTVQNFIDLAQGEKEFLSRNGQKVKKPFYDGLTFHRVIENFMIQG
CCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCC
GCPNGDGTGGPGYRFEDEINGKSLGLDQVKAGESPYYQYQLQKVVANELQIKNREEAETK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
RELIEKAFEDAKKLSVLEILFRTGYKYNEILKSHKAVKGSLAMANAGPNTNGSQFFINQV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECC
DTPHLDGLHTVFGQLVTGEDVVDKIVKTGNSKTTIKKVLIVDKRNVTTTPQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]