Definition Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession NC_005823
Length 4,277,185

Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 45657694

GI number: 45657694

Start: 2226964

End: 2228775

Strand: Reverse

Name: guaA

Synonym: LIC11831

Alternate gene names: 45657694

Gene position: 2228775-2226964 (Counterclockwise)

Preceding gene: 45657697

Following gene: 45657692

Centisome position: 52.11

GC content: 36.64

Gene sequence:

>1812_bases
ATGGTTATCCATAAAAAAATCGCCGTGGTTGATTTTGGCGGACAATATGCTCATTTAATTGCTTCTAGAATTAGAAGACT
TGGGGCATATACGGAAATTCTTTCTAACGAAGAACCTATTTCTAATTATCAAAAGTATTCAGGTATCATTCTTTCCGGTG
GTCCGGAAAGCGTTTATGAGCCAAATTCTCCTACCGTTACAACTAGAATTTTTGATTTAGGAATTCCTATACTTGGAATC
TGTTACGGTCATCAACTTATTATGAAATTATTAGGCGGTGTTGTAGAACGTTCTGGAACTGGAGAATACGGTCCTGCTTC
TCTACAACTTCATGGAACCAATGGAAATTCTATTTTGAAAAATTTCGTAGGTGGGGAGCAGGTTTGGATGAACCACGCGG
ATGAAGTTGTAAAACTTCCAGAAGGTTTTTCTAAAATTGCTTTTTCTAAAGATTGCGGTTATGCGGTTGTTGCAAATTCA
TCTAAGAAAATTTTTGGAATTCAGTTTCATGCAGAAGTTAGTCATAGCGAAAAAGGTTCGGTTCTTTTAGATAATTTCAT
TCAAATTTGTGGGGTTTCTAAAACTTGGGGAATCGATCAGTTTTTAAAAGAAAAAATCAAAGAGATTCAAGAAACAGTTA
AACAAGAACAGAAAATTTTTATGCTCGTTTCTGGAGGTGTGGATTCTACGGTTTCTTACCTTCTTTTGTGTAAGGCTCTT
GGTGCTGAAAGAGTTTTAGGTTTTTTGATTGATACTGGTTTTATGAGAAAAGACGAAGTTGTTTCTCTTCAAAAAAAATT
AACTTTTCAGAATATTCACCTAACAGTGAGAGACGAATCCTCTCTTTTTTATAAAAGTTTAAAAGATAAATCCGATCCGG
AAGAAAAAAGAAAAATTGTAGGTAATTTATTTTTAGAAGCGAGAGATCGTGCTGTAAAAGATTTAGATCTGGAATACGGA
GATTGGCTTTTAGGTCAAGGTACTATTTATCCGGATACGATCGAATCTGGTGGAACCAAACATTCGCATACCATTAAAAC
GCATCACAATCGGGTAGAAGCGATTCAAAAACTGATTGAACAAGGAAAAGTAATAGAACCGATTCGGGATCTTTATAAAG
ACGAGGTAAGGGATTTAGGTGTCCTTCTGGGTTTGGAATCGGAATGGGTAGGGCGTCATCCGTTTCCAGGACCGGGGCTT
GTGGTTCGTATGCTCGCAGTAGAAAAAAAAGGAACCGATAAGGATCAGTTGGAAATTGATTCCTATCTTTCGACCCAAGA
TGGGTTGTCCGGAAAAATTCTTCCGATTGCAAGTGTGGGTGTCAAAGGAGACAGAAGGTCTTATGCCAATTGTGTTGTGT
TAAACGACATTGAAACAGATTGGAACACTTTAGATCGTGTAGCTACTCATCTTTCAAACCGATTTTCTTTTATCAATCGA
GTGGTTCTTTTACCTTTTGAATCGGATCTTAAAAAATGGAACTTTCAATTTACTGGAATGCAGTTAGATAAAAAATGTTC
GGACTTACTCCGTGAAGCTGATTTTACAGTTGAATCCGTGATTCGTAAATTGGGACTTTATAATAAAATCTGGCAGATGC
CTGTGGTTTTACTTCCGATTGGAGAAAAGGAGAATGAAAAAAGTATCGTCCTTCGTCCTGTAGAATCTCAAGAAGCGATG
ACTGCTAATTTTTTTAGGATGGAACGTTCTGTTTTACAAGAAATTAAAATAGAAGTTCTAAAAATTCCTGAAATTCGTTA
TCTATTTTTTGATCTCACGAACAAACCTCCCGGAACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
CGTTTTCATGGACAATTTCCTTGATAACCAGATTTTTTGATCTTGTAATTGCGAAAATTCTTTTTCCCGAATCGATAGCA
AAGTCCAGAAGAGGCTTGAA

Downstream 100 bases:

>100_bases
TTGATTCAATTATTTTAATGTAGATTCGATTTAAAAATTGAGAGAAAATTTTAAGCGCGTTCAGAAAACAGATGAACTTT
GCTTCGTTGAAAGATTAGAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MVIHKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPISNYQKYSGIILSGGPESVYEPNSPTVTTRIFDLGIPILGI
CYGHQLIMKLLGGVVERSGTGEYGPASLQLHGTNGNSILKNFVGGEQVWMNHADEVVKLPEGFSKIAFSKDCGYAVVANS
SKKIFGIQFHAEVSHSEKGSVLLDNFIQICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSLKDKSDPEEKRKIVGNLFLEARDRAVKDLDLEYG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEQGKVIEPIRDLYKDEVRDLGVLLGLESEWVGRHPFPGPGL
VVRMLAVEKKGTDKDQLEIDSYLSTQDGLSGKILPIASVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINR
VVLLPFESDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVLLPIGEKENEKSIVLRPVESQEAM
TANFFRMERSVLQEIKIEVLKIPEIRYLFFDLTNKPPGTIEWE

Sequences:

>Translated_603_residues
MVIHKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPISNYQKYSGIILSGGPESVYEPNSPTVTTRIFDLGIPILGI
CYGHQLIMKLLGGVVERSGTGEYGPASLQLHGTNGNSILKNFVGGEQVWMNHADEVVKLPEGFSKIAFSKDCGYAVVANS
SKKIFGIQFHAEVSHSEKGSVLLDNFIQICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSLKDKSDPEEKRKIVGNLFLEARDRAVKDLDLEYG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEQGKVIEPIRDLYKDEVRDLGVLLGLESEWVGRHPFPGPGL
VVRMLAVEKKGTDKDQLEIDSYLSTQDGLSGKILPIASVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINR
VVLLPFESDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVLLPIGEKENEKSIVLRPVESQEAM
TANFFRMERSVLQEIKIEVLKIPEIRYLFFDLTNKPPGTIEWE
>Mature_603_residues
MVIHKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPISNYQKYSGIILSGGPESVYEPNSPTVTTRIFDLGIPILGI
CYGHQLIMKLLGGVVERSGTGEYGPASLQLHGTNGNSILKNFVGGEQVWMNHADEVVKLPEGFSKIAFSKDCGYAVVANS
SKKIFGIQFHAEVSHSEKGSVLLDNFIQICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSLKDKSDPEEKRKIVGNLFLEARDRAVKDLDLEYG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEQGKVIEPIRDLYKDEVRDLGVLLGLESEWVGRHPFPGPGL
VVRMLAVEKKGTDKDQLEIDSYLSTQDGLSGKILPIASVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINR
VVLLPFESDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVLLPIGEKENEKSIVLRPVESQEAM
TANFFRMERSVLQEIKIEVLKIPEIRYLFFDLTNKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=673, Percent_Identity=35.8098068350669, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=36.6602687140115, Blast_Score=302, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71992717, Length=694, Percent_Identity=32.7089337175792, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI133901714, Length=694, Percent_Identity=32.7089337175792, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI71992710, Length=694, Percent_Identity=32.7089337175792, Blast_Score=325, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323873, Length=506, Percent_Identity=40.3162055335968, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI281365319, Length=672, Percent_Identity=34.2261904761905, Blast_Score=350, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_LEPIC (Q72RB7)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001780.1
- ProteinModelPortal:   Q72RB7
- SMR:   Q72RB7
- GeneID:   2771690
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11831
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BioCyc:   LINT-130-01:LINT-130-01-001780-MONOMER
- BioCyc:   LINT267671:LIC_11831-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 67914; Mature: 67914

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 81-81 ACT_SITE 170-170 ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MVIHKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPISNYQKYSGIILSGGPESVYE
CEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCCCCCC
PNSPTVTTRIFDLGIPILGICYGHQLIMKLLGGVVERSGTGEYGPASLQLHGTNGNSILK
CCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
NFVGGEQVWMNHADEVVKLPEGFSKIAFSKDCGYAVVANSSKKIFGIQFHAEVSHSEKGS
HHCCCHHHHHCCHHHHHCCCCCHHHHEECCCCCEEEEECCCCEEEEEEEEEECCCCCCCC
VLLDNFIQICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLCKAL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHH
GAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSLKDKSDPEEKRKIV
CHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEEEEEEECCHHHHHHHHCCCCCHHHHHHHH
GNLFLEARDRAVKDLDLEYGDWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIE
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QGKVIEPIRDLYKDEVRDLGVLLGLESEWVGRHPFPGPGLVVRMLAVEKKGTDKDQLEID
CCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
SYLSTQDGLSGKILPIASVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINR
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCE
VVLLPFESDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVLLPI
EEEEECHHHHHHCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHCCCEEEEEC
GEKENEKSIVLRPVESQEAMTANFFRMERSVLQEIKIEVLKIPEIRYLFFDLTNKPPGTI
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCC
EWE
CCC
>Mature Secondary Structure
MVIHKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPISNYQKYSGIILSGGPESVYE
CEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCCCCCC
PNSPTVTTRIFDLGIPILGICYGHQLIMKLLGGVVERSGTGEYGPASLQLHGTNGNSILK
CCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
NFVGGEQVWMNHADEVVKLPEGFSKIAFSKDCGYAVVANSSKKIFGIQFHAEVSHSEKGS
HHCCCHHHHHCCHHHHHCCCCCHHHHEECCCCCEEEEECCCCEEEEEEEEEECCCCCCCC
VLLDNFIQICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLCKAL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHH
GAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSLKDKSDPEEKRKIV
CHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEEEEEEECCHHHHHHHHCCCCCHHHHHHHH
GNLFLEARDRAVKDLDLEYGDWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIE
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QGKVIEPIRDLYKDEVRDLGVLLGLESEWVGRHPFPGPGLVVRMLAVEKKGTDKDQLEID
CCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
SYLSTQDGLSGKILPIASVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINR
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCE
VVLLPFESDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVLLPI
EEEEECHHHHHHCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHCCCEEEEEC
GEKENEKSIVLRPVESQEAMTANFFRMERSVLQEIKIEVLKIPEIRYLFFDLTNKPPGTI
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCC
EWE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA