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The map label for this gene is mutY

Identifier: 45657486

GI number: 45657486

Start: 1975744

End: 1976871

Strand: Direct

Name: mutY

Synonym: LIC11614

Alternate gene names: 45657486

Gene position: 1975744-1976871 (Clockwise)

Preceding gene: 45657485

Following gene: 45657487

Centisome position: 46.19

GC content: 34.57

Gene sequence:

>1128_bases
GTGAAATTAAATAAGAACTCAATCGATCCGAAACTTATCTTGGAACTTAGGAAAAATCTACTTTCTTGGTTTCATAAAAA
CAAAAGAGAACTACCGTTTAGAATTAATAAAAACGCATATAGAATTTGGGTGAGCGAGATTATGCTTCAGCAAACTCGGG
TCACTGCGATGCTTCCGATTTATGAAACTTTTTTAAAAAGATTTCCAGATCCGAACTCATTGAGCGAAGCTTCAGAAGAA
GAAGTGATGAAATATTGGAAAGGACTCGGATATTATTCTAGGGCTAAAAATTTAAAAAAAGGAGCTAGGCTTCTCGTCGA
AAAATACCAAAGTCGTTTTCCTGAAAATTATGAAGAGGCACTTTTAATTCCGGGAGTAGGGAGTTATACTGCTTCTGCCG
TTTTGTCGATCGCCTATGGAAAACCTCATGCAGTTTTAGACGGAAATGTAAAACGAGTTTTATCTAGATTATTTTTGGTT
GAGTCTGACCCTAGCTTAACTTCGACTAACCAAACCCTTGCGGATCTAGCAAAAGAATTTTTAACCCCACAATCTCCAGG
AGATCATAACGAAGCTGTAATGGAATTAGGAGCTCTCGTTTGTGTTCCGATTCCAAATTGTTCTGCTTGTCCATTACAAA
ATCATTGTGAAGCAAGATCTGTAGGAAAAGAAAAAGAAATCCCTGCCTCTAAGTCCGTAGAGAATTGGATAGATCTGGAT
CTCAATTTTCTTTTTTTGAAATCAGAAGATAAAGTTCTTTTGGTGAAATATACAACTCGAAGATTTTTTAAAACGATCTA
TTCTTTGCCGTTTCGATTAGAAGGAAAACATCCCTATGAAAAGGACGAATGGATAGAGGAATTATTTGAAGATTCTAGAA
TCGTTCCAAATTTTCTGCAAACAAAACATTCGATTACTAATCACAGGATTAGATTGAAATTTTGTGACCTATATGAGAAA
AACATTTCTAAAGTTGAAAAAAATCTGAAAAAAAATAAACACATAGAATTTAAATGGGTGCCAGAGTCAGAACTTAAAGA
AGAATTTCCTTCTTCCATTTCCGGTAAACTAATTAAACTCAGAAATAAAAACAAAAAACAACCAGAACTTCCGGTGGGAA
AATTATGA

Upstream 100 bases:

>100_bases
TTTAGAATTAATGCTTAATAAAATACTAAATTATGATTTTCTGAAGATCAATTTTTTTTACTGAGTGTTCCAATCAATTC
TTTTTTAAAACCAAATTACA

Downstream 100 bases:

>100_bases
AAATTAAATCTACTTCGGAATTTGTAAAAGAATTACAAATACAAAATGAACTTTTAATTATTGAAGAAGAAGTAGATCCA
ATATTAGAATTAGCTGAAAT

Product: A/G specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPIYETFLKRFPDPNSLSEASEE
EVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEALLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLV
ESDPSLTSTNQTLADLAKEFLTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLD
LNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQTKHSITNHRIRLKFCDLYEK
NISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKLRNKNKKQPELPVGKL

Sequences:

>Translated_375_residues
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPIYETFLKRFPDPNSLSEASEE
EVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEALLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLV
ESDPSLTSTNQTLADLAKEFLTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLD
LNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQTKHSITNHRIRLKFCDLYEK
NISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKLRNKNKKQPELPVGKL
>Mature_375_residues
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPIYETFLKRFPDPNSLSEASEE
EVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEALLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLV
ESDPSLTSTNQTLADLAKEFLTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLD
LNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQTKHSITNHRIRLKFCDLYEK
NISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKLRNKNKKQPELPVGKL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=242, Percent_Identity=42.5619834710744, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI115298654, Length=242, Percent_Identity=42.5619834710744, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI115298652, Length=242, Percent_Identity=42.5619834710744, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI115298650, Length=242, Percent_Identity=42.5619834710744, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI6912520, Length=238, Percent_Identity=42.8571428571429, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI190358497, Length=238, Percent_Identity=42.8571428571429, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1789331, Length=258, Percent_Identity=37.984496124031, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787920, Length=149, Percent_Identity=28.8590604026846, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43518; Mature: 43518

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPI
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
YETFLKRFPDPNSLSEASEEEVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEA
HHHHHHHCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHE
LLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLVESDPSLTSTNQTLADLAKEF
EEECCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLD
CCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCC
LNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQ
EEEEEEECCCCEEEEEHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHH
TKHSITNHRIRLKFCDLYEKNISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKL
HHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHCCCEEEE
RNKNKKQPELPVGKL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPI
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
YETFLKRFPDPNSLSEASEEEVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEA
HHHHHHHCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHE
LLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLVESDPSLTSTNQTLADLAKEF
EEECCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLD
CCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCC
LNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQ
EEEEEEECCCCEEEEEHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHH
TKHSITNHRIRLKFCDLYEKNISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKL
HHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHCCCEEEE
RNKNKKQPELPVGKL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]