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The map label for this gene is accA2

Identifier: 45657390

GI number: 45657390

Start: 1874272

End: 1875939

Strand: Direct

Name: accA2

Synonym: LIC11517

Alternate gene names: 45657390

Gene position: 1874272-1875939 (Clockwise)

Preceding gene: 45657389

Following gene: 45657391

Centisome position: 43.82

GC content: 42.03

Gene sequence:

>1668_bases
TTGAAAGGTTCTCTCATGTCCGAAGCAAAGTATTCCCTGGAAAATCCATTTCAATCCACTTCCGAACCTGAAGTTCTTAA
GCCCCGTGGTCTTTATGAAGAAGCAAATGAGTTGGGAAAAGAACTACTCAACAAACCTCTTTTAGGCGGTGGAGTCGATA
GGATTTTAGTTCAACATTCCAAAGATAGGATGACCGTCTGGGAAAGGATTAAGGTGCTTACGGATCAAGAACCCAATATT
CTCTATCAAAACTGGGGAAAAAGTTTAGACGGAGCTTCTTTAGTTACAGGGATTCTAAACATCAATGGTAGAGACGTGGC
CGTCTACGGTCACGATTTTACTCTTCGCGCGGGTTCGATGGATGCTACCAACGGAAGTAAACTTGCAAGACTGATTTATA
TGGCAGGAGAACACGGTATTCCTCTGATTGGTATGAACGATTCCGCAGGAGCTTATGTTCCCGCCGGAGTGGGAGGACTG
GACGGATATAGCGAGGCGTTTACCGCACTTCGTAAGATCAGCGGAGTAGTTCCTAGTTTGATGCTTATGTTTGGGTTCAA
TGCGGGTGGGGGAGCTTATCTTCCGCGTCAGGGATCTTTTATGATTCAGTGTGACAATACCTTCTTTGGTTTAACTGGTC
CCGGAGTCGTTAAATCGGTATTAGGTGAAGATATTTCCGCAGATGATTTAGGAGGTCCCAAGGTTCACGGACAGAGCGGC
GTAGTGGATATTGTTACCGGGGACGAGTTGGGTTCTTTGAGAACCGCTCTTCGTTTACTTTCTTATCTTCCAGATAACAA
TCATTCCTTTGCTCCTTTTCATGCTACTTCCGATCCTACCAATAGATTTATCTACGAAGAAGAAATTTTATTTAAGAAAA
CATTCAATTCTCCTACTGGAATGAATACTCCTTTTGACATCACTTTGTATCTGCAAAATATTTGCGATCATGGTCAATAT
TTCGAAATCCAAGGACAACGTTCTAGAAACTTGGTGACTGCTTTCGGAAGAATTGGAGGACACGTTGTCGCTTTTGTTGC
CAATAACTCTGCGGTTTCTTCCGGACAGATAGACATTGGTGCGGCGAGAAAAGGAACTAGATTTATTCGATTCTGCAACC
TTTATAATATTCCAATCGTTTTTTTAGAAGACACGACTGGGTTTTTACCCGGAAAAGAGCAGGAACAAAACGGAATTGTA
CTCGAAGGAAGAAAACTTTTAGATTCTATCATAGACATTCGTACACCTCGTTTAACATTGATTATTCGAAATGCTTTCGG
AGGTGCTTACGCTTGTTTTAATTCTTATCACACCGGGGCGGATATGGTGTTTGCGCTTCCGACTGCTAGAATTGCGGTGA
TGGGTCCGGCCGGAAAAGACTACGTTTATAAGGACGAGGTTTCTTCTATTCAAAAAGAATATCAGGAAAATGTAAAGAAG
GGAATGTCTGAAAAAGAAGCCATCGTAATTCGAGATAAAAAACTTCAGACACTTTCTACTCAATACGAAAAAGAACTGAT
GAATCCTAAAGAAGCTCTTTCTCTCGGTTCCGTTTCTAGAATTGTCCTTCCTGGAACGACCAGAAATATTCTTTTCCAAA
ATCTGGATTATTTAATCCGACATTATAAACCGGCTCCGTTGTCCGGACCTCAAAGGGAGTTTGAGTAA

Upstream 100 bases:

>100_bases
ACTCTAGAATCCGCTATAAAATAGTTTCTCTTCTCACATTCGACTCGAATTTAACTTTCCCGAGAATCCTTTCTTTAAAA
ACTGGATTTATTTTATTCCA

Downstream 100 bases:

>100_bases
TCTAACATGATCGACTTTCAGAACAATCGTATTCAATTTCATCAGTCCAGTTCTCCTTGGATCCGTTCTTTTTCTTTGGA
ATCGATCAAATGTCTGATCG

Product: acetyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKGSLMSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHSKDRMTVWERIKVLTDQEPNI
LYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSMDATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGL
DGYSEAFTALRKISGVVPSLMLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSG
VVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTGMNTPFDITLYLQNICDHGQY
FEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIGAARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIV
LEGRKLLDSIIDIRTPRLTLIIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKK
GMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIRHYKPAPLSGPQREFE

Sequences:

>Translated_555_residues
MKGSLMSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHSKDRMTVWERIKVLTDQEPNI
LYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSMDATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGL
DGYSEAFTALRKISGVVPSLMLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSG
VVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTGMNTPFDITLYLQNICDHGQY
FEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIGAARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIV
LEGRKLLDSIIDIRTPRLTLIIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKK
GMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIRHYKPAPLSGPQREFE
>Mature_555_residues
MKGSLMSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHSKDRMTVWERIKVLTDQEPNI
LYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSMDATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGL
DGYSEAFTALRKISGVVPSLMLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSG
VVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTGMNTPFDITLYLQNICDHGQY
FEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIGAARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIV
LEGRKLLDSIIDIRTPRLTLIIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKK
GMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIRHYKPAPLSGPQREFE

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=530, Percent_Identity=33.7735849056604, Blast_Score=286, Evalue=5e-77,
Organism=Homo sapiens, GI295821216, Length=550, Percent_Identity=32.5454545454545, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=27.3921200750469, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI38679971, Length=317, Percent_Identity=26.1829652996845, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679974, Length=317, Percent_Identity=26.1829652996845, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679960, Length=317, Percent_Identity=26.1829652996845, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679977, Length=317, Percent_Identity=26.1829652996845, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679967, Length=317, Percent_Identity=26.1829652996845, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI134142062, Length=365, Percent_Identity=25.2054794520548, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=33.59375, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI25147359, Length=512, Percent_Identity=33.59375, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17552936, Length=529, Percent_Identity=26.8431001890359, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323863, Length=354, Percent_Identity=21.4689265536723, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586065, Length=554, Percent_Identity=27.0758122743682, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI161076407, Length=317, Percent_Identity=24.6056782334385, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24586460, Length=317, Percent_Identity=24.6056782334385, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24586458, Length=317, Percent_Identity=24.6056782334385, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161076409, Length=317, Percent_Identity=24.6056782334385, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 60838; Mature: 60838

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSLMSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHS
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
KDRMTVWERIKVLTDQEPNILYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSM
CCHHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHEECCCCEEEEECCCEEEECCCC
DATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSL
CCCCHHHHEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSG
HHHHCCCCCCCCCCCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCCCCCCCCEECCCCC
VVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTG
EEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEEHHHHHEEECCCCCCC
MNTPFDITLYLQNICDHGQYFEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIG
CCCCEEEEEEEHHHHCCCCEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCEEEC
AARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIVLEGRKLLDSIIDIRTPRLTL
CCCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEE
IIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKK
EEEECCCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHC
GMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIR
CCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
HYKPAPLSGPQREFE
HCCCCCCCCCCCCCC
>Mature Secondary Structure
MKGSLMSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHS
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
KDRMTVWERIKVLTDQEPNILYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSM
CCHHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHEECCCCEEEEECCCEEEECCCC
DATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSL
CCCCHHHHEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSG
HHHHCCCCCCCCCCCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCCCCCCCCEECCCCC
VVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTG
EEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEEHHHHHEEECCCCCCC
MNTPFDITLYLQNICDHGQYFEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIG
CCCCEEEEEEEHHHHCCCCEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCEEEC
AARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIVLEGRKLLDSIIDIRTPRLTL
CCCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEE
IIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKK
EEEECCCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHC
GMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIR
CCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
HYKPAPLSGPQREFE
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]