Click here to switch to the map view.

The map label for this gene is erg10

Identifier: 45657191

GI number: 45657191

Start: 1618309

End: 1619466

Strand: Direct

Name: erg10

Synonym: LIC11311

Alternate gene names: 45657191

Gene position: 1618309-1619466 (Clockwise)

Preceding gene: 45657187

Following gene: 45657192

Centisome position: 37.84

GC content: 38.43

Gene sequence:

>1158_bases
TTGATTTTCAATCTCACAATTTTTAAAAACATAGACCCGATGTATTCATCTGCTTTTATTATTGATTCTGAACTCAGTCA
TTTTGGAAAGACTGAACTTGATTATCATTCTCTTTCTTATCAAACAGCAATTCAACTTTTGGAAAGAAATTCTGAGTTTG
AACCTCAGTTTCTTATTTTTGCAGCGATGGCTCCGGAACGTTATACGGGAGAGGTGTTTGTTTCTGCTCGGATCAAAGAA
AGTCTTGGTTTGAAAAATTTATTTACGATTCGCACAGAGACTGCTTCTTCTTCCGGTGCAAGTGCTCTTCATACCGCTGT
TTATTTACTTCGTTCTGGAGCGTTTCAAAGAGGAATTATAATTGCTACCGAAGTGATGAGTCGTCTTGAAAGAGAAGAGA
ACAATCTTCTTTTAGGAAGTGTTTTATCGGAACGACAAAAAGGTTTTGCTATGTCCATGGCTCAAGGAGGAGGAATGATC
GCTACACGTTATCTGCAACAGTACGGATATGATCGTAGGGATCTTTATTTACTTTCTAAAAAGTTACACGATAACGGACT
TAAAAACGAAAAGGCCCATATCAAAAAAAATATTACAGAAGTAGAATATTTTAATTCTCCTGTATTTACAAGTCCACTTT
GTCTTTACGATATTTCTCCTCTTTCCGATGGAAGTTGTGCGGTTTTACTGAGTTCCGAAAAAACAAAATCTTCTCGATCT
TTAGAAATACGTGGAATTGGGCACGGGATCGGAAATCTTTCCAATCCGCCGGGAGATTTAAGTTTTAGCTCTAGTGTAAC
CGCGTTTCAAGGCGCATACAAAGAGGCAAATTTAAAACCGGAGCAGATTCAAATTGCAGAGTTGCACGACGCTTTTACAC
CTTTTGAGTTGATAGGAGCAGAGGATGCGAAACTTTTTCCGAGAGGTTCTGCATTGCGTTATGTGAAAGAGGGAAAAACT
CATCCAGAAGGACAACTTCCTATCAACGCATCGGGAGGTTTAAAAACCAGAGGTCATCCAGTGGGAGTTTCTGGGCTGGC
ACAAATTGCTGAATTACAAAGTTGGATGTTTAAAAAAGAACGTTTTCAAAACGGTTTGGCTCTTTCTATCGGAGGTTTGG
GTGTGAATAATTTTGCTACGATTCTTTCTAAAGTTTAA

Upstream 100 bases:

>100_bases
CTCCTTGTGATCATTTCAGTATAAAAATCATTCTTAATTTTGCAAGGATAGTTTATAAACATGGATGAAAAGTCGTCTTA
CTTGTGTTATTTAATTTTTT

Downstream 100 bases:

>100_bases
AACGGAATTGAACGTGAACGAAAAAATACTTTTGATTCAAACCGCTTTTTTAGGAGATTTGATTTTAACGACTTCTTTCT
TTAGAGAAGTCAAAAAAAAA

Product: acetyl-CoA C-acyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIFNLTIFKNIDPMYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIFAAMAPERYTGEVFVSARIKE
SLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGIIIATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMI
ATRYLQQYGYDRRDLYLLSKKLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRS
LEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGAEDAKLFPRGSALRYVKEGKT
HPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKERFQNGLALSIGGLGVNNFATILSKV

Sequences:

>Translated_385_residues
MIFNLTIFKNIDPMYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIFAAMAPERYTGEVFVSARIKE
SLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGIIIATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMI
ATRYLQQYGYDRRDLYLLSKKLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRS
LEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGAEDAKLFPRGSALRYVKEGKT
HPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKERFQNGLALSIGGLGVNNFATILSKV
>Mature_385_residues
MIFNLTIFKNIDPMYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIFAAMAPERYTGEVFVSARIKE
SLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGIIIATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMI
ATRYLQQYGYDRRDLYLLSKKLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRS
LEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGAEDAKLFPRGSALRYVKEGKT
HPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKERFQNGLALSIGGLGVNNFATILSKV

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI302344760, Length=318, Percent_Identity=24.8427672955975, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923233, Length=318, Percent_Identity=24.8427672955975, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI302344767, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI302344762, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537653, Length=319, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921506, Length=310, Percent_Identity=26.1290322580645, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585051, Length=310, Percent_Identity=26.7741935483871, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42381; Mature: 42381

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFNLTIFKNIDPMYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIF
CEEEEEEECCCCCHHHCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
AAMAPERYTGEVFVSARIKESLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGII
EEECCCCCCCEEEEEEEHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
IATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMIATRYLQQYGYDRRDLYLLSK
EHHHHHHHHHHHCCCEEEHHHHHHHHCCCEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHH
KLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRS
HHHCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCC
LEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGA
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHCCCCCHHHEEHHHHHCCCCCHHEECC
EDAKLFPRGSALRYVKEGKTHPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKE
CCCCCCCCCCHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RFQNGLALSIGGLGVNNFATILSKV
HHCCCCEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure
MIFNLTIFKNIDPMYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIF
CEEEEEEECCCCCHHHCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEE
AAMAPERYTGEVFVSARIKESLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGII
EEECCCCCCCEEEEEEEHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
IATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMIATRYLQQYGYDRRDLYLLSK
EHHHHHHHHHHHCCCEEEHHHHHHHHCCCEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHH
KLHDNGLKNEKAHIKKNITEVEYFNSPVFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRS
HHHCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCC
LEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGA
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHCCCCCHHHEEHHHHHCCCCCHHEECC
EDAKLFPRGSALRYVKEGKTHPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKE
CCCCCCCCCCHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RFQNGLALSIGGLGVNNFATILSKV
HHCCCCEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]