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The map label for this gene is ephD [H]

Identifier: 45656888

GI number: 45656888

Start: 1218493

End: 1219404

Strand: Direct

Name: ephD [H]

Synonym: LIC11000

Alternate gene names: 45656888

Gene position: 1218493-1219404 (Clockwise)

Preceding gene: 45656886

Following gene: 45656889

Centisome position: 28.49

GC content: 33.55

Gene sequence:

>912_bases
ATGAATAATAGGAGAATCGAAAGTTTGAAATATACATATTTAGAAAATCAAAAAGTGAAACTGTTTCTCTCTTATTCAGA
AACGGATTCTAAGAATGTGATTCTATTTGTTCACGGTTATCCGGATACACATAAAACTTGGGATTTACAGGTCAATGTTT
TGAAGGAAAAATTTACATTAGGTGCAATTGATCTAAGAGGGTCTGGAAGATCTTCTAAGCCCTCAGAACAATCTGAATAT
AACTATACAATGATTCTTTCTGATTTATTGGAGGCGATTCGTTTTCTTTCCAAAGATAAAAAAGTTCATTTAGTCGGTCA
CGACTGGGGAGCCGCGCTTGGTTGGTTATTTATTAGTGATTTTGAATATTCTAAATATGTAAGTTCTTTTACTGCTATTT
CCGGCCCTCATCCTTGGCTTGCTGGAAAAAGGATAATAGACGACTTATTCAGTTTTGATTTAAGTAATTGGAGTAAGGTG
ATCGATCAGGGTTTTCGTTCTTGGTATATATGGTTTTTTCAAATTCCTGTATTACCGGAACTCATTTGGCAAAACTTTGG
CGAATCGATTTACAAATGGATCATGGATTGGGGCGGGGTTCCTAAAAAAGATTCTCTAAGGAAAGTGAATAAAAACGATA
TTTATAACTCTACTATTGCTCCCATTAATTTGTTCCGAGAATTATTATTTGGTAAAACGGTCATTTCGTCTCCTTCTCAT
ATTAAAGTTCCAGTGCAGTTAATTGTTCCTCAAAAAGATTTTATCGTTTTACCGGAAGTCTACGAAAACTCTTACGATTA
TGTTGAAAAATTAGAAATTCATAAAATACCATCCAATCATTGGGTTCACAGAGAACAACCAGACTTAGTAACTGAACTCA
TTCAAAAGTTTGTTTTTAAATATTCCATCTAA

Upstream 100 bases:

>100_bases
GAATTTAAAAGTGTTACTGATCTCTATAAAATTGAGTACTGTTAATTTTATCACAAAACGCTGGTTCCATACAAAATATT
AGGTACTTTATTATATAGTT

Downstream 100 bases:

>100_bases
GACAAAATGGCGCCCCTTCTGGGCTTGAAAACGTGGGTTAGATGCAAGAAACAAGAAAACCAACAGAAGGAACTAAAGTG
AAAAGAAAGGTATGTAGGAA

Product: short-chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNNRRIESLKYTYLENQKVKLFLSYSETDSKNVILFVHGYPDTHKTWDLQVNVLKEKFTLGAIDLRGSGRSSKPSEQSEY
NYTMILSDLLEAIRFLSKDKKVHLVGHDWGAALGWLFISDFEYSKYVSSFTAISGPHPWLAGKRIIDDLFSFDLSNWSKV
IDQGFRSWYIWFFQIPVLPELIWQNFGESIYKWIMDWGGVPKKDSLRKVNKNDIYNSTIAPINLFRELLFGKTVISSPSH
IKVPVQLIVPQKDFIVLPEVYENSYDYVEKLEIHKIPSNHWVHREQPDLVTELIQKFVFKYSI

Sequences:

>Translated_303_residues
MNNRRIESLKYTYLENQKVKLFLSYSETDSKNVILFVHGYPDTHKTWDLQVNVLKEKFTLGAIDLRGSGRSSKPSEQSEY
NYTMILSDLLEAIRFLSKDKKVHLVGHDWGAALGWLFISDFEYSKYVSSFTAISGPHPWLAGKRIIDDLFSFDLSNWSKV
IDQGFRSWYIWFFQIPVLPELIWQNFGESIYKWIMDWGGVPKKDSLRKVNKNDIYNSTIAPINLFRELLFGKTVISSPSH
IKVPVQLIVPQKDFIVLPEVYENSYDYVEKLEIHKIPSNHWVHREQPDLVTELIQKFVFKYSI
>Mature_303_residues
MNNRRIESLKYTYLENQKVKLFLSYSETDSKNVILFVHGYPDTHKTWDLQVNVLKEKFTLGAIDLRGSGRSSKPSEQSEY
NYTMILSDLLEAIRFLSKDKKVHLVGHDWGAALGWLFISDFEYSKYVSSFTAISGPHPWLAGKRIIDDLFSFDLSNWSKV
IDQGFRSWYIWFFQIPVLPELIWQNFGESIYKWIMDWGGVPKKDSLRKVNKNDIYNSTIAPINLFRELLFGKTVISSPSH
IKVPVQLIVPQKDFIVLPEVYENSYDYVEKLEIHKIPSNHWVHREQPDLVTELIQKFVFKYSI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=301, Percent_Identity=24.2524916943522, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI218777840, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI13376164, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17554012, Length=301, Percent_Identity=25.9136212624585, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562298, Length=277, Percent_Identity=26.3537906137184, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: NA

Molecular weight: Translated: 35541; Mature: 35541

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRRIESLKYTYLENQKVKLFLSYSETDSKNVILFVHGYPDTHKTWDLQVNVLKEKFTL
CCCCCCHHEEEEEECCCEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEEEEEHHHHEE
GAIDLRGSGRSSKPSEQSEYNYTMILSDLLEAIRFLSKDKKVHLVGHDWGAALGWLFISD
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHEEC
FEYSKYVSSFTAISGPHPWLAGKRIIDDLFSFDLSNWSKVIDQGFRSWYIWFFQIPVLPE
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEEEHHHHHH
LIWQNFGESIYKWIMDWGGVPKKDSLRKVNKNDIYNSTIAPINLFRELLFGKTVISSPSH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHCCCCC
IKVPVQLIVPQKDFIVLPEVYENSYDYVEKLEIHKIPSNHWVHREQPDLVTELIQKFVFK
EEEEEEEEECCCCEEECCHHHCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHH
YSI
CCC
>Mature Secondary Structure
MNNRRIESLKYTYLENQKVKLFLSYSETDSKNVILFVHGYPDTHKTWDLQVNVLKEKFTL
CCCCCCHHEEEEEECCCEEEEEEEECCCCCCEEEEEEECCCCCCCEEEEEEEEEHHHHEE
GAIDLRGSGRSSKPSEQSEYNYTMILSDLLEAIRFLSKDKKVHLVGHDWGAALGWLFISD
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHEEC
FEYSKYVSSFTAISGPHPWLAGKRIIDDLFSFDLSNWSKVIDQGFRSWYIWFFQIPVLPE
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEEEHHHHHH
LIWQNFGESIYKWIMDWGGVPKKDSLRKVNKNDIYNSTIAPINLFRELLFGKTVISSPSH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHCCCCC
IKVPVQLIVPQKDFIVLPEVYENSYDYVEKLEIHKIPSNHWVHREQPDLVTELIQKFVFK
EEEEEEEEECCCCEEECCHHHCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHH
YSI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]