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The map label for this gene is fadE25 [H]

Identifier: 45656858

GI number: 45656858

Start: 1169606

End: 1170862

Strand: Direct

Name: fadE25 [H]

Synonym: LIC10970

Alternate gene names: 45656858

Gene position: 1169606-1170862 (Clockwise)

Preceding gene: 45656857

Following gene: 45656859

Centisome position: 27.35

GC content: 41.69

Gene sequence:

>1257_bases
TTGGTTTTTTCCTTTATATTTTGGTTTGATCTAATCACTGTAAAAAAAAAAGTAGGATTAGAATATTCTCTTAAGATAAG
AAGGGCAAAACCGATGTACCAGGAATTTACCGAACAACAGCTCGAGATCAGAGACCAGATTCGCAATTTCGTGAAAAAAG
AAATTACTCATGAAGTCGCTATCCACTGGGACGAAGAAAATAAACACCCAGAAGAACTCATCAATCGTATGCGAAAAGAA
CTAGGAGTGAATGGTTTAACCATTCCCGAAGAATACGGTGGTTGGGGACTTGGTTCTGTTGAACAGTGTCTTGTAACTGA
AGAGCTTTCCAGAGGATGTCTCGGAATATCTCTTTGTTTTGGTTATACGGGCCTCGGAATTCTTCCAATTCTAAAAGGTG
CTTCTCATGAGCAGAAGAAAAAATGGCTACAACCTGTGGTCGATGGAGAATACGGAGTATCTTTCTGTCTTTCCGAGCCT
GGTGCAGGATCAGACGTTCCTGGAATGAGTACTACAGCTGTAAAGAAAGGTGATAAGTGGGTTATCAACGGCACTAAACA
GTGGATTACAGGTGGAGGTAGTGCAGGAGCTTATACAGTATTTGCATATACTGATAAAGGAAGAGGAACTAGGGGAGTAA
GTTGTTTCTACGTAAAGAGAGACACTCCAGGACTGACCGTTGGTAAAAAAGAAGATAAACTTGGAATCCGTGCTTCCGAT
ACTCGTCAGATCATCTTTGAAGATTGTGCGGTAGAAGAAGCGAATATGATCGGAAAAGAAAATTTAGGATTTATTTATGC
GCTTCAAACATTAAACGCATCTCGCCCTTACGTTGCGGCGATGGGAGTGGGGGTTGCTCAAGCGGCTCTTGATTACGCTT
CCAAATATGCAAGACAAAGGGAGCAGTTCGGATCTAAGATTTCTAGTTTCCAGGCGGTGCAGCATATGCTTGCGGATATG
TCCATTGGTCTAGAAACTTCTCGTCAAGTTACTTATCTCGCGGCGAGAATGTCCGACGCAGATGATCCTAGACTTCCAAA
ATATTCTGCAATTGCAAAGGCTCACGCATCTGAAACCGCGATGAAATGTGCTTTAGATGCGGTTCAAATTTTCGGAGGAT
ACGGTTATACAAAAGAATATCCAGTCGAAAAATTAATGAGAGACGCGAAAATTCTTTGTATCTTTGAAGGAACAACTCAG
ATTCAGAAAAACGAGATTGCCGCTTATGTAATTCGTGAGGCAGCATCCGCTAAATAA

Upstream 100 bases:

>100_bases
CTTTGAAATTTTAGAAGGAACTTGTTTTAAAAAGATTTTTGAGAACCTGAAAAGTTTCCAACATGGAATGAATAAAAAAA
AATAAAAAACAAACAGATCA

Downstream 100 bases:

>100_bases
GAAAATTAGAATTTTTGAAAGTATGTTCCGATTGGGACAATTTGAGAAAATTGAATCTGGACTGAAACGAAAGTTTAAAA
GTTTGGATCAGAGAGACAGG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVAIHWDEENKHPEELINRMRKE
LGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEP
GAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASD
TRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQREQFGSKISSFQAVQHMLADM
SIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQ
IQKNEIAAYVIREAASAK

Sequences:

>Translated_418_residues
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVAIHWDEENKHPEELINRMRKE
LGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEP
GAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASD
TRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQREQFGSKISSFQAVQHMLADM
SIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQ
IQKNEIAAYVIREAASAK
>Mature_418_residues
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVAIHWDEENKHPEELINRMRKE
LGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEP
GAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASD
TRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQREQFGSKISSFQAVQHMLADM
SIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQ
IQKNEIAAYVIREAASAK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=372, Percent_Identity=44.8924731182796, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI187960098, Length=372, Percent_Identity=44.8924731182796, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI4557233, Length=389, Percent_Identity=42.159383033419, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=39.8950131233596, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=36.8279569892473, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI226958414, Length=367, Percent_Identity=37.6021798365123, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=35.8778625954198, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=33.3333333333333, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI76496475, Length=371, Percent_Identity=33.9622641509434, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557235, Length=371, Percent_Identity=33.9622641509434, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=30, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=30.6068601583113, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=31.1977715877437, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI38505218, Length=332, Percent_Identity=27.710843373494, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI48976061, Length=392, Percent_Identity=22.9591836734694, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI211971008, Length=392, Percent_Identity=22.9591836734694, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081958, Length=368, Percent_Identity=30.4347826086957, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=28.1914893617021, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082384, Length=322, Percent_Identity=23.2919254658385, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=45.0402144772118, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=41.9270833333333, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=43.9473684210526, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=39.1534391534392, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=38.28125, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=37.9032258064516, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=35.6164383561644, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=38.3512544802867, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=40.8695652173913, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=385, Percent_Identity=30.1298701298701, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=397, Percent_Identity=29.4710327455919, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=29.6495956873315, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=32.3943661971831, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=33.469387755102, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=29.0220820189274, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=27.1276595744681, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=356, Percent_Identity=26.9662921348315, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=184, Percent_Identity=30.9782608695652, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=47.9784366576819, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI21356377, Length=382, Percent_Identity=42.4083769633508, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=38.8888888888889, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=39.0374331550802, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI21355753, Length=373, Percent_Identity=37.5335120643432, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=34.7826086956522, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24652780, Length=339, Percent_Identity=23.3038348082596, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 46341; Mature: 46341

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVA
CEEHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCF
EEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEHHHHH
GYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEPGAGSDVPGMSTTAVKKGDKW
HHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCEE
VINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASD
EECCCHHEECCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCC
TRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQR
CHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVA
CEEHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCF
EEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEHHHHH
GYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEPGAGSDVPGMSTTAVKKGDKW
HHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHCCCCCEE
VINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASD
EECCCHHEECCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCC
TRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQR
CHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]