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The map label for this gene is tktA

Identifier: 45656802

GI number: 45656802

Start: 1096630

End: 1097496

Strand: Direct

Name: tktA

Synonym: LIC10913

Alternate gene names: 45656802

Gene position: 1096630-1097496 (Clockwise)

Preceding gene: 45656801

Following gene: 45656804

Centisome position: 25.64

GC content: 38.52

Gene sequence:

>867_bases
TTGAGGTTGGGAATTGCATCATCTTATTCGCTTAGGAAAAATATGAACGAGATCAAAGAAATTAAGAACTTTGCAAATGA
ACTCAGAAAGAGTGTAATCAAAATGGTAACCGCTGCAAATTCGGGCCATCCAGGCGGTCCCTTAGGTCTTGCTGATATTT
ATGCGGTTTTATATAAGAAAATCTTAAATCATAAACCTTCCGATCCGGATTGGGAAGAAAGGGATCGTTTGATTCTTTCC
AACGGTCACGTATGTGCGATTCGTTATGCGGCTATGGCTCATTCCGGTTATTTTCCTTTAGAAGATTTGATGACCTTTCG
CAAATTGGGAAGTAAACTTCAAGGTCACCCCTCTACCCGTTATATGAACGGCATCGAAAGCTCTTCTGGTTCTTTGGGTC
AAGGACTTTCTGTTTCCGTTGGCCTTGCACTGGGTGCTAGATTCAAAAAACAAAATCATAAAATTTATACCTGTATCTCT
GACGGAGAATGTGGCGAAGGAATGACCTGGGAAGCAGCTCAATCCGCTGTACACTATAAATTAGACAATCTGATTGCTTT
TATGGATAAGAATGGAATTCAGATTGATGGTTTTACAAAAGACGTGATGAATCTAGAGCCTCTAAAAGAAAAATTTATTT
CTTTTGGTTGGAACGTTTTGGAAGCAGATGGTCATGATGTAGAACAAATTATCTCCGCATTTGAAAAAGCAAAACTTCAT
AAAGGATCTCCTACGATTATTCTTTTTAAAACTGTACTTGGAAAAGGTGTTTCTTTTATGGAGAATAATCCGGGATGGCA
CGGGACCCCTCCTAAACCGGAAGAAGAAAAAAAAGCTCTCGAAGAATTATCTACAATTTCTATTTAA

Upstream 100 bases:

>100_bases
GAAAGCTACACTATATTTTCCTTCCTCTATACACTGCTATTTTCCTTTCCGGTTTGGTATTGTTTCGTTCTTCGAACTGA
CCTTATTCCGGCATCCTGTT

Downstream 100 bases:

>100_bases
AGAAATTTCTCTTAATTGTCGTTAGGTGAGATTTTGGGTTGGCACTTTCTTTGAAAGTGCTTCGTTCAATAGATTTTAAT
ATAAGATTTTTATTATAGAT

Product: transketolase subunit alpha protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MRLGIASSYSLRKNMNEIKEIKNFANELRKSVIKMVTAANSGHPGGPLGLADIYAVLYKKILNHKPSDPDWEERDRLILS
NGHVCAIRYAAMAHSGYFPLEDLMTFRKLGSKLQGHPSTRYMNGIESSSGSLGQGLSVSVGLALGARFKKQNHKIYTCIS
DGECGEGMTWEAAQSAVHYKLDNLIAFMDKNGIQIDGFTKDVMNLEPLKEKFISFGWNVLEADGHDVEQIISAFEKAKLH
KGSPTIILFKTVLGKGVSFMENNPGWHGTPPKPEEEKKALEELSTISI

Sequences:

>Translated_288_residues
MRLGIASSYSLRKNMNEIKEIKNFANELRKSVIKMVTAANSGHPGGPLGLADIYAVLYKKILNHKPSDPDWEERDRLILS
NGHVCAIRYAAMAHSGYFPLEDLMTFRKLGSKLQGHPSTRYMNGIESSSGSLGQGLSVSVGLALGARFKKQNHKIYTCIS
DGECGEGMTWEAAQSAVHYKLDNLIAFMDKNGIQIDGFTKDVMNLEPLKEKFISFGWNVLEADGHDVEQIISAFEKAKLH
KGSPTIILFKTVLGKGVSFMENNPGWHGTPPKPEEEKKALEELSTISI
>Mature_288_residues
MRLGIASSYSLRKNMNEIKEIKNFANELRKSVIKMVTAANSGHPGGPLGLADIYAVLYKKILNHKPSDPDWEERDRLILS
NGHVCAIRYAAMAHSGYFPLEDLMTFRKLGSKLQGHPSTRYMNGIESSSGSLGQGLSVSVGLALGARFKKQNHKIYTCIS
DGECGEGMTWEAAQSAVHYKLDNLIAFMDKNGIQIDGFTKDVMNLEPLKEKFISFGWNVLEADGHDVEQIISAFEKAKLH
KGSPTIILFKTVLGKGVSFMENNPGWHGTPPKPEEEKKALEELSTISI

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=277, Percent_Identity=37.1841155234657, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI4507521, Length=277, Percent_Identity=37.1841155234657, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI133778974, Length=273, Percent_Identity=34.7985347985348, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI225637459, Length=273, Percent_Identity=27.8388278388278, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI225637461, Length=273, Percent_Identity=27.1062271062271, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI225637463, Length=230, Percent_Identity=28.695652173913, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1788808, Length=274, Percent_Identity=40.5109489051095, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI48994911, Length=266, Percent_Identity=39.0977443609023, Blast_Score=185, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17539652, Length=252, Percent_Identity=38.4920634920635, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6319593, Length=278, Percent_Identity=38.4892086330935, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=278, Percent_Identity=38.1294964028777, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45551847, Length=269, Percent_Identity=39.0334572490706, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI45550715, Length=269, Percent_Identity=39.0334572490706, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24666278, Length=258, Percent_Identity=39.5348837209302, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645119, Length=226, Percent_Identity=42.0353982300885, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 31841; Mature: 31841

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGIASSYSLRKNMNEIKEIKNFANELRKSVIKMVTAANSGHPGGPLGLADIYAVLYKK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ILNHKPSDPDWEERDRLILSNGHVCAIRYAAMAHSGYFPLEDLMTFRKLGSKLQGHPSTR
HHCCCCCCCCHHHHCCEEECCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHH
YMNGIESSSGSLGQGLSVSVGLALGARFKKQNHKIYTCISDGECGEGMTWEAAQSAVHYK
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHH
LDNLIAFMDKNGIQIDGFTKDVMNLEPLKEKFISFGWNVLEADGHDVEQIISAFEKAKLH
HHHHHHHHCCCCCEECCCHHHHHCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHC
KGSPTIILFKTVLGKGVSFMENNPGWHGTPPKPEEEKKALEELSTISI
CCCCCEEEEHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLGIASSYSLRKNMNEIKEIKNFANELRKSVIKMVTAANSGHPGGPLGLADIYAVLYKK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ILNHKPSDPDWEERDRLILSNGHVCAIRYAAMAHSGYFPLEDLMTFRKLGSKLQGHPSTR
HHCCCCCCCCHHHHCCEEECCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHH
YMNGIESSSGSLGQGLSVSVGLALGARFKKQNHKIYTCISDGECGEGMTWEAAQSAVHYK
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHH
LDNLIAFMDKNGIQIDGFTKDVMNLEPLKEKFISFGWNVLEADGHDVEQIISAFEKAKLH
HHHHHHHHCCCCCEECCCHHHHHCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHC
KGSPTIILFKTVLGKGVSFMENNPGWHGTPPKPEEEKKALEELSTISI
CCCCCEEEEHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]